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Biomedical subjects

I Dobó

Publications and source records attributed to I Dobó.

10 recordsLinked to original sources
PubMed1996

Tissue concentrations and correlations of prostaglandins in healthy and inflamed human esophageal and jejunal mucosa.

The PGE2, PGF2 alpha, PGI2, and TXB2 content in biopsies of healthy esophageal mucosa and inflamed mucosa and from subjects with chronic esophagitis was measured and statistically analyzed. No significant differences were found between the tissue concentrations of prostaglandins in the inflamed and the healthy mucosa, except for elevated PGI2 content in the inflamed esophageal mucosa in comparison to healthy mucosa. The prostaglandin content of jejunal mucosa was unchanged in jejunitis and in atrophy compared to findings in healthy subjects. Regression analysis revealed a significant negative correlation between the PGF2 alpha and PGI2 content in both inflamed esophageal and inflamed jejunal mucosa. In healthy mucosa, no correlation was found between the tissue concentrations of these two prostaglandins, either in the esophagus or in the jejunum. These results suggest the redistribution of cyclic endoperoxide metabolism under certain pathological conditions.

Analysis of Variance↗
PubMed1990

[Tomato skin in the common bile duct after endoscopic sphincterotomy].

Lithotomy and endoscopic sphincterotomy were carried out in a 83-year-old woman because of choledocholithiasis. One year later calculi and tomato skins were found in the common bile duct. Significance is attributed to the tomato skins in the development of calculi. The attention is drawn to the observation that operative interventions performed through the Vater's papilla, spontaneous or iatrogenic choledochoduodenal fistulas create favourable conditions for foreign material to get into the choledochus and this may cause lithogenesis.

Aged↗
PubMed1989

[A simple isotope method for studying of gastric emptying of solid foods].

A simple isotope method is explained by the authors for noninvasive functional evaluation of the gastric emptying of solid meal. According to the results of in vitro measurements suitable solid phase labelling was provided by boiling the egg traced with injected Tc-99m-pertechnetate. The evaluation of gastric emptying by means of test meal containing the radiolabelled boiled egg is simple, inexpensive and the radiation hazard is minimal. In cases of intact stomach the gastric emptying of solids (T2 = 115.1 +/- 12.4 min) were significantly slower, than in cases of Billroth I (T2 : 66.7 +/- 6.9 min, p less than 0.01) and Billroth II (T2 = 28.8 +/- 3.3 min, p less than 0.001) resections. Similarly, there was a significant difference (p less than 0.001) between the mean half time values of the two operated groups.

Adult↗
PubMed1988

Mucosal prostaglandin levels of the gastric stump.

The endogenous mucosal PG levels (PGE2, PGF2 alpha, PGI2, TXB2) of the gastric stump were investigated from biopsy materials, after partial gastrectomy made for ulcer disease. The mucosa of the stomach remnant were found to contain mainly PGE2 and PGI2. The PG contents of the mucosa of gastric stump were not influenced by the type of resection. Mucosal PG concentrations on the greater curvature were not dependent on the patients' age, the indication of the gastrectomy, the duration of postoperative interval, or the sex of the patient. There was no relation between the secretion capacity of the resected stomach and the mucosal PG contents of the greater curvature. After Billroth I and II gastrectomy procedures equivalently fair correlations have been established between the mucosal levels of PGE2 and PGF2 alpha, PGE2 and TXB2, PGF2 alpha and TXB2, PGI2 and TXB2 on the greater curvature, respectively. After both types of gastrectomy the mean PGI2 mucosal concentration of the greater curvature was significantly lower than those of the gastroenteroanastomosis and lesser curvature below the cardia, which in turn did not differ from each other. Biliary reflux does not cause characteristic alterations of the mucosal PG levels on the greater curvature. No definite relation between the histological findings of the mucosa and the PG concentrations was observed, which suggests a secondary role of the endogenous PGs in the pathogenesis of light microscopic mucosal alterations of the resected stomach.

Adult↗