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Biomedical subjects

I Dobronyi

Publications and source records attributed to I Dobronyi.

33 records · Page 2Linked to original sources
PubMed1985

Immunotoxicological investigation of the effects of a pesticide; cypermethrin.

The effects of a synthetic pyrethroid pesticide cypermethrin on the immune system were studied. The effect of a daily oral administration of 1/40, 1/20 and 1/10 of LD50 was studied in rabbits for its influence on the humoral immune response after vaccination with Salmonella typhi, as well as on cell-mediated immunity. The two higher doses induced a significant dose-dependent decrease of serum antibody titers. The skin redness measured in the tuberculin skin test showed the same dose-dependent tendency. In subacute experiments with rats, a significant dose-dependent decrease was observed both in the anti-ovalbumin titer of blood sera measured in passive hemagglutination test and in the autologous rosette-formation of T-lymphocytes in groups fed the higher doses.

Animals↗
PubMed1985

A rare case of infantile meningioma.

This paper reports the use of ultrasound and computed tomography in combination to diagnose a case of meningioma in a 3-month-old infant, and also describes the treatment.

Female↗
PubMed1985

Binding of lincomycin to immunoglobulins has no effect on their antigen-binding capacity.

The interaction of lincomycin and immunoglobulins was examined in vitro. While lincomycin bound to the immunoglobulin molecules seemed to decrease the quantity of IgG and IgM detected by radial immunodiffusion and microzone electrophoresis, the level of specific antibodies could not be demonstrated by enzyme-linked immunosorbent assay (ELISA).

Antibodies, Viral↗
PubMed1984

Possible role of lincomycin-therapy in the genetic alteration of a staphylococcus epidemic population.

In a staphylococcosis epidemic occurring in a child community, the proportion of inducible lincomycin resistance has risen significantly in the bacterium population. This conveyed the possibility that lincomycin or its derivatives may induce a lincomycin resistance in Staphylococcus aureus as it is already known in streptococci. Examination of human and animal samples obtained during lincomycin treatment showed that lincomycin had no role in the induction of resistance; the agent can effectively be applied against pathogens of the above-mentioned phenotype. Immunological examination of serum samples provided opportunity for a more exact localization of the protein-linkage of lincomycin.

Animals↗
PubMed1983

Cerebrovascular occlusion in childhood.

Among 2493 patients undergoing cerebral angiography 43 children were found to have cerebrovascular occlusion. The diagnosis, aetiology, management and care of the condition is outlined. It is stressed that angiography is indispensable in diagnosis.

Arterial Occlusive Diseases↗
PubMed1982

Binding of different ligands to IgM-Fc receptors of rat leucocytes.

The primary receptor ligand interaction between rat leucocyte membrane receptors for IgM and their ligands were examined. We found that the incubation time for optimal IgM binding is different on the two types of IgM-Fc receptor-bearing spleen cells and peritoneal macrophages. The investigation of cytophilic activity of polyclonal or monoclonal IgM proteins and their fragments from various species indicated the fine specificity of receptors. Finally, data are presented which suggest a multiple point co-operative binding between IgM-coated erythrocytes and IgM-Fc receptor-bearing cells.

Animals↗
PubMed1981

IgM-Fc receptor-mediated phagocytosis of rat macrophages.

The features and function of IgM-FcR of rat peritoneal macrophages were studied. Macrophages specifically bind and phagocytose ox red blood cells coated with rat IgM (EA-IgM) through a specific receptor. This receptor is trypsin sensitive and its activity requires Ca++ ions. Both sodium azide and low temperature (4 degrees) inhibit the bindings as well as ingestion of EA-IgM by macrophages, suggesting the metabolically dependent character of the interaction between EA-IgM and macrophages. Colchicine inhibits the binding of EA-IgM by macrophages. Similarly, the ingestion of EA-IgM was also inhibited when peritoneal exudate cells (PEC) were pre-treated with colchicine or vinblastine or cytochalasin B. It is suggested that cytoskeletal elements of macrophages play an important role both in the binding of EA-IgM to their receptors and in the subsequent internalization of the receptor-ligand complexes. Ingestion of soluble IgM antibodies containing immune complexes (IC) resulted in a release of beta-glucuronidase from macrophages.

Animals↗