Biomedical subjects
Publications and source records attributed to I E Lisnianskiĭ.
A complex (population, clinico-familial, cytogenetic and biochemical) investigation was performed in 50 cases of thyroid medullary cancer and their relatives. The study evaluated the diagnostic value of tests used to identify hereditary forms of the disease which accounted for one-third of the cases. Guidelines for identification of groups at high risk for thyroid medullary carcinoma are discussed.
Three syndromes of multiple endocrine neoplasia (MEN) have been identified to date: MEN--I, IIa and IIb. They involve various combinations of endocrine neoplasia and occur mostly in young patients. Predisposition transmission mechanism is autosomal-dominant with total penetration and variable expressiveness. Patients' families should undergo screening which involves identification of biochemical markers and cytogenetic examination. This would allow identification of subjects at high risk for cancer and improvement of early diagnosis.
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