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Biomedical subjects

I E Sofieva

Publications and source records attributed to I E Sofieva.

14 recordsLinked to original sources
PubMed1989

[The role of changes in central and intracardiac hemodynamics in lowering the physical work capacity of patients with ischemic heart disease and diabetes mellitus].

The data of bicycle ergometry test and echocardiography were studied and compared in patients with postinfarction cardiosclerosis and type II diabetes mellitus without the clinical signs of heart failure. The patients showed the decreased work fitness and the identity of cardiovascular responses to graded exercise, pointing to the common character of the pathogenesis of these diseases. Both groups of the patients manifested the hyperkinetic type of the central hemodynamics as well as the lowering of the rate of diastolic relaxation and the rise of the end diastolic volume of the left ventricle. The intracardiac hemodynamics of coronary heart disease was characterized, in addition, by the reduction of myocardial contractility of the left ventricle due to focal injuries to the myocardial structures, which are more pronounced than in diabetes mellitus.

Adult↗
PubMed1988

[Hemodynamic mechanisms of the decrease in physical work capacity in hypothyroidism and thyrotoxicosis].

A study of 21 patients with hypothyroidism, 22 patients with thyrotoxicosis and 18 normal subjects, using echocardiography and bicycle ergometry, demonstrated different mechanisms of reduced working capacity, associated with those conditions. The decrease in chronotropic and inotropic heart reserve, associated with hypothyroidism, is shown to be rooted in slowed-down relaxation of left ventricular posterior wall in the presence of diastolic arterial hypertension, while limited working capacity, associated with thyrotoxicosis, is rooted in resting myocardial hyperfunction due to hyperkinetic circulation.

Adult↗
PubMed1988

[The characteristics of cardiac lesions in patients with X-linked myopathy].

A patient with advanced X-linked myodystrophy and marked cardiovascular changes is described. Current understanding of the problem of heart muscle involvement in the myodystrophic process as well as treatment of such patients are analysed on the basis of data reported in Soviet and foreign literature.

Adult↗
PubMed1988

[Functional status of the myocardium in thyrotoxicosis].

Twenty-two patients with thyrotoxicosis, showing no clinical signs of heart failure were examined electro- and echocardiographically. Bicycle ergometry was also used in 13 of those. Central and intracardiac hemodynamics were assessed at rest, as was cardiovascular response to exercise. The results were compared to similar parameters in 18 normal subjects. Echocardiography demonstrated hyperkinetic circulation and normal myocardial contractility in the resting patients. Bicycle ergometry showed considerably limited working capacity in those patients. Limited chronotropic and inotropic reserve of the heart in the presence of increased left-ventricular operation at rest may be pathogenetically involved in reduced stress tolerance, seen in patients with thyrotoxicosis.

Adult↗
PubMed1987

[Tolerance of the cardiovascular system of hypothyroidism patients for physical loading].

Twenty-one patients with primary hypothyroidism were subjected to electro- and echocardiography, and 10 patients, to bicycle ergometry, to examine their central and intracardiac hemodynamics at rest and cardiovascular response to exercise. The results were compared with the respective parameters of 18 normal subjects. Hypothyroidism was shown to be associated with increased left-ventricular myocardial weight (echocardiographic evidence in the presence of normal myocardial contractility at rest, lowered stress tolerance due to a smaller chronotropic reserve of the heart, and myocardial metabolic disorders.

Adult↗
PubMed1987

[Changes in the systemic and intracardiac hemodynamics of healthy persons as affected by emotional tension].

Twenty-four normal subjects were examined during exposure to emotional stress, simulated by mental arithmetic exercise under time shortage and interfering light and sound stimuli. Hemodynamic parameters were determined on the basis of echocardiographic M-records in resting condition and under mental stress. Irrespective of the baseline hemodynamic type, emotional stress produced a hyperkinetic circulatory response. Increased cardiac index resulted from higher heart rate in the presence of unchanged venous return and stroke index. Myocardial contractility increased to a greater extent in individuals with hypokinetic and eukinetic hemodynamics.

Adult↗
PubMed1983

[Relation between hormonal and hemodynamics indices during emotional stress in healthy individuals and in hypertensive patients].

Relationships between hormonal and hemodynamic parameters were examined during emotional stress in normal subjects and patients with essential hypertension. Plasma renin activity, aldosterone, cortisol concentration in the plasma and ACTH level, urinary catecholamine excretion were assayed, and arterial blood pressure, heart rate, ECG were recorded in 29 normal controls and 39 hypertensive patients before and after exposure to emotional stress. The findings were processed using the cluster technique of multivariable statistical analysis. Emotional stress was shown to produce more correlations in the system of hormonal balance compared to resting conditions, the interhormonal correlations being more pronounced in hypertensive patients as compared to normal controls. Stress-induced hypertensive response was shown to be achieved via different means: predominantly sympathoadrenal activation in normal subjects and the activation of renin-angiotensin-aldosterone system in hypertensive patients.

Adrenal Cortex↗