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Biomedical subjects

I E Tareeva

Publications and source records attributed to I E Tareeva.

At least 19 recordsLinked to original sources
PubMed1992

[Acute kidney failure in patients with chronic glomerulonephritis].

The causes of acute renal failure (ARF) and results of its treatment are analyzed in 34 patients aged 15 to 51 years with exacerbation of chronic glomerulonephritis (CGN). Of these, 20 patients presented with lupoid GN, 11 with Bright's GN, and 3 had GN associated with systemic vasculitis (2 of them also had mixed cryoglobulinemia). All the patients underwent clinical treatment that lasted from January 1, 1986 to December 31, 1990. In 15 patients, ARF was due to the activity of the underlying disease or development of its complications (nephrotic crisis, disseminated intravascular coagulation, cryoglobulinemia); in 15 patients, it was determined by complications induced by drug treatment (diuretics, antibiotics, nonsteroid antiinflammatory drugs), and in 4 patients, by complications related to invasive examinations (radiographic contrast studies) and treatment (isolated ultrafiltration). The authors hold that superaddition of progressive tubular disorders, rapid decrease of the rate of glomerular filtration accompanied by the growth of serum creatinine form the basis for ARF to be diagnosed in such patients. Identification of the cause of ARF and delimitation of whether the pathological process is renal or prerenal in CGN patients is required for rational treatment prescription.

Acute Kidney Injury↗
PubMed1991

[The treatment of chronic glomerulonephritis with ultrahigh doses of cyclophosphane].

Pulse therapy with cyclophosphamide was administered to 44 patients with chronic glomerulonephritis of the nephrotic type with different morphological varieties. The treatment was effective in 59% of cases including 11 out of 24 patients resistant to oral treatment with immunosuppressors. The treatment results were better in patients with normal blood serum creatinine and normal arterial pressure. Remission of the nephrotic syndrome could be observed in mesangioproliferative glomerulonephritis, mesangiocapillary glomerulonephritis, mesangial glomerulonephritis and focal-segmentary hyalinosis. In fibroplastic nephritis, remission of the nephrotic syndrome was recorded in none of the cases. The only prognostically significant sign predicting the treatment effect was the activity index--the totality of the morphological signs reflecting nephritis activity. The sclerotic changes produced no significant effect on the treatment outcome.

Adolescent↗
PubMed1991

[The role of mononuclear leukocytes in the pathogenesis of glomerulonephritis].

To specify the role of mononuclear (MN) leukocytes in the development of mesangial cell proliferation, which is one of the main manifestations of glomerulonephritis, cell cultures of renal glomeruli of rats with nephrotoxic serum (NTS) nephritis were examined for the intensity of mesangial cell proliferation, the MN-leukocyte count, and for IL-1 production. The amount of mesangial cells and the intensity of their proliferation in the cultures of glomerular cells from rats with NTS nephritis were much higher than in intact rat cultures. At the same time the glomerular cultures from rats with NTS nephritis demonstrated an increase in the MN leukocyte count together with enhancement of IL-1 production. The treatment with prednisolone averted accumulation of MN leukocytes by the glomerular cultures and noticeably reduced mesangial cell proliferation. The supernatant liquid of cultures of peripheral blood MN leukocytes from patients with active nephritis suppressed human fibroblast proliferation, exerting no such action on mesangial cell culture. During the treatment with prednisolone, the supernatant liquid produced a reverse effect on fibroblast and mesangial cell cultures, which was associated with the clinical improvement of the health status. It is assumed that mesangial cell proliferation seen in nephritis may be related to infiltration of the glomeruli by MN leukocytes and to elevated production by them of IL-1 and that the therapeutic action of prednisolone may be determined by suppression of these processes.

Animals↗
PubMed1991

[Interleukin-1 production by mononuclear leukocytes and mesangial cells in experimental nephrotoxic nephritis].

We investigated the intensiveness of the cell proliferation, number of mononuclear leucocytes (MNL) and production of interleukin-1 (IL-1) in glomerular cell cultures of rats with nephrotoxic serum (NTS) nephritis and control (C) rats. Five days after intravenous injection of nephrotoxic serum from rabbits the glomeruli were isolated, treated with collagenase and cultured over a period of 20 days. In cultures the number and intensity of mesangial cell proliferation in the NTS group were significantly higher than in the C group. Thus, the intensive mesangial cell proliferation in experimental nephrotoxic serum nephritis is related to infiltration of glomerulus by MNL of bone marrow origin with increased production of IL-1.

Animals↗
PubMed1990

[Calcium antagonists in the treatment of nephrogenic hypertension].

Monotherapy with calcium antagonists nifedipine, foridon and verapamil hydrochloride was assessed in 46 patients with chronic glomerulonephritis and arterial hypertension by hypotensive effect and changes in systemic and renal hemodynamics, water-electrolytic balance, renin-angiotensin system. It is shown that nifedipine and foridon act as peripheral vasodilators. A hypotensive effect manifested most potently in nifedipine administration. None of the drugs aggravated renal hemodynamics, elevated intraglomerular tension, activated renin-angiotensin system, promoted water and sodium retention. Calcium antagonists are thought a treatment of choice in management of nephrogenic hypertension.

Adolescent↗
PubMed1990

[The renal functional reserve in the nephrotic syndrome].

Functional reserves of the kidneys (FRK) were examined in 29 patients with the nephrotic syndrome and in 14 healthy subjects. FRK were determined as the degree of the increase of endogenous creatinine clearance after stimulation with beef protein (0.7 g per kg bw) or dopamine (3 micrograms/min per kg bw). It was revealed that in 2/3 of the patients, FRK were lowered or lacking. The lack of FRK was seen in all the morphological varieties of renal lesions, with the frequency being greater in the severe clinical forms of the nephrotic syndrome, in lasting nephropathy, in association with arterial hypertension or renal failure. It has been noted that FRK may recover after successful treatment of the nephrotic syndrome, attesting to a favourable regimen of organ functioning and suggesting deceleration of the tempo of renal disease progress.

Adolescent↗
PubMed1990

[The action of cyclophosphane in different morphological variants of glomerulonephritis in mice].

Heterologous serum glomerulonephritis (GN) was induced in CBA and C57BL mice. CBA mice developed diffuse proliferative GN. Glomerular changes in C57BL mice corresponded to the mesangial GN with proliferation of glomerular mesangial cells and mesangial infiltration with mononuclear phagocytes. Single administration of cyclophosphamide (CP) at the time of immunization exerted different effect on the development of the two morphological variants of GN. In CBA mice CP treatment resulted in disappearance of the immune complexes deposits with no influence on the cell reactions. In C57BL mice CP completely inhibited the development of the glomerular morphological changes. The lack of morphological similarity is most likely connected with the immunological differences in the histocompatibility complex (H-2).

Animals↗
PubMed1989

Detection of measles virus genome in blood leucocytes of patients with certain autoimmune diseases.

RNA isolated from lymphocytes of peripheral blood was dot-hybridized to a hybrid plasmid containing specific sequences for measles virus nucleocapsid protein. Viral RNA was detected in the lymphocytes of 28 of 34 (82%) patients with systemic lupus erythematosus (SLE) and of 40 of 68 (59%) patients with chronic glomerulonephritis (CGN), and was not detected in 29 control patients.

Antibodies, Monoclonal↗