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Biomedical subjects

I F Latypov

Publications and source records attributed to I F Latypov.

8 recordsLinked to original sources
PubMed2006

[The effect of methyl-containing supplements during pregnancy on the phenotypic modification of offspring hair color in rats].

The effect of methyl supplements to the diet of pregnant homozygous (AAHH) female rats with agouti coat color mated with homozygous (aahh) males on the phenotypic modification of the coat color of their heterozygous offspring (AaHh) has been studied. Comparative morphological analysis of the main parameters of hair that determine coat color, including the total length of hairs of different types and the length of the upper black (eumelanin) and light (pheomelanin) parts of awn hairs has been performed. The pattern of pigment granule distribution among hair layers has been analyzed. The melanin content of the hair has been determined using electron spin resonance (ESR). Although all offspring have a typical agouti coat color (alternating black and light portions of hair), 39% of them have a darker coat color than control and other experimental rats have. The main differences between the offspring with darkened and standard coat colors are accounted for by the ratio between the eumelanin and pheomelanin portions of awn hairs. In darkened offspring, this ratio is significantly higher than in control rats. The possible mechanisms of the phenotypic modification of agouti coat color in experimental animals are discussed.

Agouti Signaling Protein↗
PubMed2002

[Morphology of hair pigmentation in wild red foxes, silver foxes, and their hybrids].

The effects of dominant allele Ar of locus Agouti on the morphology of hair pigmentation were described in foxes. The Ar allele was shown to determine the type of melanin and its content in hair with no effect on the morphology of pigment granules and their distribution throughout a hair. Using the method of electron spin resonance (ESR), the types of melanin (eumelanin and pheomelanin) and their content in the hair of red (ArArEE) and silver (aaEE) foxes and their hybrids (AraEE) were determined. In silver foxes, only one type of melanin (eumelanin) was found. In red foxes and their hybrids (which are phenotypically similar but darker than red foxes), both types of melanin (eu- and pheomelanin) were found. The highest melanin content was detected in the coat of silver foxes. In the hybrids, the total melanin content was lower than in silver foxes, but significantly higher than in red foxes. In red foxes, the contribution of pheomelanin to the total hair melanin content was twice as large as in the hybrids.

Animals↗
PubMed1997

[Variability of pheomelanin content in wool of Karakul lambs and the problem of phenetics of color].

In samples of wool from 1,229 differently colored newborn Astrakhan lambs, the total content of melanins and the proportion of pheomelanin in the total melanin were studied by the method of electron magnetic resonance spectometry. An analysis of the corresponding computer data base revealed that the distribution of the samples with respect to the proportion of pheomelanin had at least four characteristic maximums; 1-6, 9-10, 28-29, and 39% of pheomelanin. The former two maximums were characteristic for the brown and Karakalpak sur colors, and the latter two maximums, for red-brown kambar color. White hair tips, characteristic for the sur color, and the proportion of pheomelanin were combined almost independently; therefore the possibility is discussed of classifying these characters as independent phenes, and some variants of sur, as their combinations.

Animals↗
PubMed1994

[Phenogenetic analysis of pigmentation of a new coat color mutation of American mink (Mustela vison. Schr. L.) and its combination with some of the known mutations].

A new dominant coat color mutation "talitsa" was revealed in the mink population of "Znamenskii" state fur farm (Tverskaya region', Russia). Qualitative analysis and quantitative assessment of the hair pigment of minks with the standard coat color, Talitsa, Royal-Pastel and American pearl mutations, as well as Talitsa x Royal-Pastel and Talitsa x American Pearl hybrids were conducted. It was shown that hair of all genotypes studied contained only one pigment type, namely, eumelanin. Hair of the standard-colored minks showed the greatest eumelanin content, whereas hair of Talitsa x Royal-Pastel and Talitsa x American Pearl hybrids showed the least content. The morphologic patterns of pigmentation of the mutant minks studied was described, including the shapes, dimensions and color of the pigment granules, as well as their distributions throughout the length and layers of the hair. Talitsa mutation was demonstrated to behave as a strong coloration attenuator in combinations with the Royal-Pastel and American Pearl mutations. It was proposed that the main mechanism determining the phenotypic expression of the Talitsa mutation is the reduction of number of melanocytes in the hair bulbs.

Animals↗
PubMed1991

Comparative analysis of hair melanins by chemical and electron spin resonance methods.

Eighteen hair samples from Karakul newborn lambs with various colors were estimated for eumelanin and pheomelanin contents (Ce and Cp, respectively) by electron spin resonance (ESR) spectrometry and by high-performance liquid chromatography (HPLC). Correlation coefficients between the values estimated by the ESR and HPLC methods were 0.96, 0.93, and 0.99 for Ce, Cp, and Ce/Cp, respectively. The high correlation coefficients show that both methods fit well for estimation of relative values of these parameters. The absolute values of Ce and Ce/Cp coincide rather well when Ce is high, but considerable discrepancies appear when Ce is low. The reasons for these discrepancies are discussed. The HPLC method appears to be more sensitive for detection of low concentrations of pheomelanin, while the ESR method fits well for mass selection purposes.

Animals↗
PubMed1991

[Verification of the color genotype based on morphological analysis of fur pigmentation of brown and black water voles Arvicola terrestris L].

Qualitative and quantitative analysis of fur pigmentation in brown and black water voles (Arvicola terrestris L.) was performed. Morphology of pigment granules, their distribution along the hair layers and histology of hair bulbs were studied. Morphological data and the results of the analysis of segregation in the progeny, when brown voles were self-crossed and crossed with black ones, led to conclusion that fur colour of water voles is mediated by genes from the agouti series, precisely, black colour is determined by the extreme non-agouti allele (aeae genotype), and in brown voles which are homo- or heterozygous the colour is determined by the agouti allele (AA or Aae genotypes).

Alleles↗