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Biomedical subjects

I F Matiushin

Publications and source records attributed to I F Matiushin.

At least 19 recordsLinked to original sources

[T and B lymphocyte function of patients with infectious complications after surgery for congenital heart defects].

The parameters of T- and B-lymphocyte system were studied in 65 patients with congenital heart defects aged from 2 to 31 years with infectious complications after operation. The investigation was performed before operation and in the course of the postoperative period. Patients with infectious complications were shown to have more considerable suppression of cell and humoral immunity before operation than those without infectious complications. The parameters concerned were found to be distinctly decreased in the early postoperative period. Two weeks after operation no normalization of the immune parameters were noted.

Adolescent

[Experimental aortic stenosis, its subsequent correction and the activity of oxidative enzymes in the myocardium].

The activity of the respiratory enzymes of myocardial mitochondria--succinatedehydrogenase and cytochromixidase--was studied in experimentally induced aortic stenosis and after its elimination in 98 mongrel dogs. The observation period of stenosis was 1, 15, 30 and 60 days, and after its elimination--1, 7, 15 and 30 days. The activity of the enzymes in question was found to grow after the production of aortic stenosis. The highest level of their enzymatic activity was observed on the 15th day after the induction of stenosis. By the 30th and 60th day the enzymatic activity underwent some decrease, although it persisted on a level above the initial. The activity of succinatedehydrogenase fell sharper. After the elimination of the stenosis the activity of both enzymes decreased, and by the 7th day it was below the initial level. By the 15th day after the removal of the ligature from the aorta the activity of both enzymes corresponded to the initial values and did not change further till the end of the 1st month. The dynamics of the activity of succinatedehydrogenase and cytochromixidase after an experimentally induced aortic stenosis and its subsequent elimination seems to depend on the nature of the changes in the function of the heart muscle performed under such experimental pathology, and on the degree of coronary flow enhancement.

Animals