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Biomedical subjects

I Figueroa

Publications and source records attributed to I Figueroa.

8 recordsLinked to original sources
PubMed1991

[Cervico-facial heterotopic brain tissue with a mandibular deformity].

Case report of a premature baby girl who presented with a right cervico-facial mass which caused severe respiratory difficulty. The patient underwent subtotal resection of the mass whose pathologic specimen report revealed heterotopic cerebral tissue compatible with encephalocele. A head and neck CT Scan performed could not evidence a connection between the mass and the cranial cavity, reason for which the possibility of encephalocele was disregarded. After subtotal resection of the mass, the tumor began to grow from soft palate and the patient died from respiratory complications at four months of age. Autopsy reported heterotopic cerebral tissue from neck and soft palate; right lung pneumonia and infection by CMV. Although the heterotopic cerebral tissue was reported as benign, the clinical characterization of this mass is compatible with a malignant behavior due to the aggressiveness of its growth.

Brain↗
PubMed1975

Steroid protection of the liver during experimental eschemia.

Temporary occlusion of hepatic inflow would be ideal during extensive operations for liver trauma or tumors, since this always is handicapped by accompanying massive blood loss. Since the liver is relatively low in tolerance to ischemia an attempt has been made to protect the liver with steroids during experimental warm ischemia. Total hepatic ischemia was produced in rabbits by ligating the portal triad and gastrohepatic ligament for 30 minutes. A survival rate of only 10 per cent was obtained in controls, whereas if methylprednisolone was given before occlusion, 100 per cent of the rabbits survived. If methylprednisolone was given immediately after the occlusion, the survival rate was 54 per cent. Further experiments extending occlusion to one hour resulted in a 50 per cent survival rate as compared with zero per cent in the one hour controls. Methylprednisolone protects the liver during warm ischemia, especially if given before occlusion, and dramatically decreases the mortality rate from this maneuver in our model. The mechanism of protection is probably by stabilizing and protecting the integrity of the hepatic cell during the anoxic insult.

Animals↗
PubMed1975

Protective effect of steroids on liver ischemia.

Occlusion of the afferent liver circulation for variable periods of time would be advantageous to temporarily control bleeding from profound lacerations or during extensive resections. Because of its low tolerance to ischemia we attempted to protect the liver with steroids during inflow occlusion. Total hepatic ischemia was produced in rabbits by ligating the portal triad and gastrohepatic ligament for 30 minutes. A 10 per cent survival was obtained in untreated controls whereas pre-treatment with methylprednisolone improved survival to 100 per cent. Methylprednisolone injection after occlusion improved survival only to 57 per cent. There were profound pathohistologic and electron microscopic changes in untreated controls. In animals treated with methylprednisolone either before or after occlusion changes were minimal or absent. This treatment was used in four trauma patients in whom occlusion of the liver inflow was carried out for various periods of time. Even though no significant statement can be made from such small group, the early postoperative course was remarkably smooth and stable. Methylprednisoline protects the liver during warm ischemia, especially if given before occlusion, and decreases the mortality from this maneuver in experimental animals.

Adolescent↗