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Biomedical subjects

I Finger

Publications and source records attributed to I Finger.

4 recordsLinked to original sources

Specific cell-induced transformation of Paramecium surface antigens.

Paramecia may induce in other paramecia specific changes in the expression of genes determining surface protein synthesis, probably via cell-to-cell contact. Transformation from one antigenic type to a newly induced one is stimulated by the pretreatment of a cell with 5-fluorouracil. These observations are considered in terms of the regulation of the activity of genes in stable cells and in unstable cells which tend to transform spontaneously.

Animals

Task characteristics and a stage 6 sensorimotor problem.

A previously demonstrated high rate of failure on a Stage 6 sensorimotor means-end problem, of children otherwise inferred to be in Stage 6 development, prompted a study of task characteristics of the problem. A component part of the task was modified by introducing an additional visual cue; the purpose of the problem was unchanged. Results indicated that problem solving was facilitated in the transformed condition, with older subjects performing somewhat better than younger subjects. The authors suggest that cognitive requirements of the problem, as representative of Stage 6 sensorimotor development, remained the same in the original or transformed condition. The modification appeared to permit children to focus their attention on the requirements of the problem, so that a greater number of children demonstrated mental representation. Task characteristics of sensorimotor problems need to be investigated further.

Age Factors