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Biomedical subjects

I Fujishima

Publications and source records attributed to I Fujishima.

9 recordsLinked to original sources
PubMed1997

Dysphagia in children with oculo-auriculo-vertebral spectrum.

Feeding difficulty necessitating tube feeding after the infantile period was seen in 3 children with oculo-auriculo-vertebral spectrum. Videofluorographic imaging showed impaired pharyngeal function, which was thought to result from dysplasia of the pharyngeal muscles. Note should be made of feeding difficulty in patients with oculo-auriculo-vertebral spectrum.

Child, Preschool↗
PubMed1992

Interstitial laserthermia in neurosurgery.

Deep-seated brain tumor is difficult to treat surgically. Hyperthermia using various energy sources has been tried, but has failed to gain wide use because of equipment problems and poor temperature control. It is possible now to use Nd:YAG laser with a stable low-energy supply as an energy source for laser hyperthermia (laserthermia). Animal study and clinical study were done using SLT CL50, Computer-control Laserthermia System to treat deep-seated brain tumors. Experimental study revealed that laserthermia produced minimal edema, temperature control was satisfactory, and blood-brain barrier opened up for 6 days following laserthermia. Five patients with brain tumors were treated with laserthermia. Follow-up CT scan revealed disappearance of tumor in 4 patients and decrease in volume in 1 patient. Long-term neurological follow up revealed no deterioration. Laserthermia using Nd:YAG laser is safe and easy to use and it is beneficial to treat deep-seated brain tumors.

Adult↗
PubMed1991

Photodynamic therapy using pheophorbide a and Nd:YAG laser.

The authors describe a new photodynamic therapy (PDT) method for malignant brain tumors. Pheophorbide a (Ph-a), the photosensitizer, has low toxicity, causes no skin sensitization and is activated with an acoustic Q switched neodymium yttrium-argon-garnet (Nd:YAG) laser which achieves deep tissue penetration. The Ph-a distribution in Fisher 344 (F344) rats bearing rat T9 glioma at 24 hours after intravenous injection was very low in the normal brain tissue, but significantly higher in the T9 glioma giving a tumor to normal brain tissue concentration ratio of 7.5:1. The in vitro survival rate of T9 glioma cells pretreated with Ph-a was 68.8 +/- 5.4% after laser irradiation for 20 minutes, significantly lower than in the control groups. This indicates that Ph-a was activated with the acoustic Q switched Nd:YAG laser causing the photodynamic effect. The survival rate after Ph-a pretreatment and laser irradiation in a waterbath at 44.0 degrees C was further reduced to 15.8 +/- 3.3%. In vivo PDT studies using T9 glioma cells inoculated into the dorsal region of F344 rats showed tumor eradication in four of six rats. The combination of PDT and laser hyperthermia produced tumor eradication in all six rats. The combination of PDT and hyperthermia is a promising method for tumor treatment.

Animals↗
PubMed1990

Stereotactic interstitial laser-hyperthermia using Nd-YAG laser.

Laser hyperthermia using Nd-YAG laser was studied experimentally and clinically to treat deep-seated brain tumors. Histological changes, temperature profile, and modification of the blood-brain barrier were studied using cat and rat brains. In a clinical study 5 patients with brain tumors were treated with laser hyperthermia using this computed tomography-stereotactic technique. All tumors of these patients disappeared on computed tomography, and 3 of the 5 patients are still alive without recurrence. It was possible to make optimal lesion and to have accurate peripheral temperature control by using the combination of the Komai stereotactic method and the SLT Nd-YAG laser system. Interstitial laser hyperthermia using this method is easy and safe to use, and it is beneficial to treat deep-seated brain tumors.

Adult↗
PubMed1988

MR imaging as predictor of delayed posttraumatic cerebral hemorrhage.

The occurrence of delayed traumatic intracerebral hemorrhage or hematomas was predicted in four patients by T2-weighted magnetic resonance (MR) imaging. From June, 1986, through February, 1987, 42 patients with head injury were admitted to the Neurosurgical Service of the Seirei Mikatabara General Hospital. Cerebral contusion was suspected in six of these patients. Although the initial computerized tomography (CT) scans showed no cerebral parenchymal lesion, the initial symptoms were more serious than might have been expected from the initial CT findings and/or because their initial CT scans showed intracranial extracerebral hemorrhage. In all six, the initial CT scans were obtained within 2 hours after the injury and were followed by MR imaging. In four patients, T2-weighted MR images revealed areas of increased signal intensity in the cerebral parenchyma, where hemorrhagic changes were subsequently demonstrated by follow-up CT scans. In the remaining two, T2-weighted MR images showed no parenchymal lesion and subsequent CT scans confirmed the absence of hemorrhagic change; these two patients were discharged from the hospital without neurological deficits. It is concluded that MR imaging is useful in predicting delayed hemorrhages.

Adult↗