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Biomedical subjects

I Furka

Publications and source records attributed to I Furka.

At least 19 recordsLinked to original sources
PubMed1996

Laparoscopic implantation of temporary electrodes for bladder stimulation in dogs.

Five female mongrel dogs were used in an acute animal experiment. Under general anesthesia two monopolar wire electrodes armed with needles on either side were implanted into the bladder wall, the leads of both electrodes were then pulled through the abdominal wall. Filling of the bladder and intravesical pressure measurement were achieved through a suprapublic percutaneous cystostomy. Electrostimulation was carried out using the XEJ-2 experimental electroejaculator (biphasic pulses, pulse width 2.5 msec, approximately 70 mAmp, 50 Hz). The pressure changes within the bladder following electrostimulation were recorded, the effect of stimulation was observed endoscopically. Electrostimulation of the bladder wall resulted in micturition in all cases, showing an initial pressure peak at the commencement of electrostimulation followed by a decrease after onset of evacuation. We believe that laparoscopic implantation of temporary wire electrodes followed by percutaneous electrostimulation may open up new possibilities for bladder rehabilitation as well as for diagnostic investigations into the contractile capabilities of the bladder.

Animals↗
PubMed1996

Effect of glucagon and somatostatin on pancreatic secretion in dogs.

The authors investigated the effects of glucagon and a somatostatin preparation (Stilamin) on the secretion volume and on the secreted and absorbed enzyme levels of the pancreas. Four groups of dogs with an artificial pancreatic fistula were given a single intravenous injection of glucagon (group I, n = 8), intravenous drip-infusion of glucagon (group II, n = 8), intravenous drip-infusion of somatostatin (group III, n = 10) and intravenous drip-infusion of the carrier fluid, physiological sodium-chloride (control, group IV, n = 5), respectively. Pancreatic juices were collected and volume, pH, bicarbonate, amilase, lipase, trypsin and protein contents were determined. Serum amilase and lipase levels before and at the termination of the experiment were also measured. Intravenous drip-infusion of both Glucagon and Stilamin decreased pancreatic secretion, Stilamin being more effective than Glucagon. On the other hand, a single i.v. injection of Glucagon resulted in an increased secretion. The authors suggest that based on the observed inhibitory effect on pancreatic secretion, both glucagon and somatostatin could be used to reduce postoperative complications of pancreatic operations in the clinical practice.

Amylases↗
PubMed1993

[Autologous spleen transplantation].

Splenectomy is known to increase the risk of overwhelming bacterial infection. There is a decrease in immunoglobulin IgM, T-lymphocytes, impaired primary antibody response to antigen challenge, an altered opsonic function and a tuftsin deficiency. Splenic autotransplantation has been suggested as a method of preserving function and this concept is supported by experiments in animals (dogs). The study describes autotransplantation of the traumatized spleen in human beings for the preservation of splenic function. Eleven patients operated on for abdominal trauma in the Kenézy Hospital in Debrecen, required total splenectomy, than splenic autotransplantation. In these patients splenic slides were implanted in between two layers of omental pouch (Furka's "spleen chip"). In 10 patients the follow-up radionuclid imaging, the IgM level, and the tuftsin level unambiguously confirmed the functioning of the splenic tissue.

Abdominal Injuries↗
PubMed1990

Experimental study of parenteral nutrition and of the exocrine function of the pancreas.

The effect of parenteral nutrition on the pancreatic secretion was studied under experimental conditions. Experiments were carried out in 24 mongrel dogs. In all animals pancreatic fistulas were created for collection of pancreatic juice. Subsequently, in three groups (6 dogs in each) parenteral nutrition via a catheter enterostomy was applied in three different segments of their small bowels, while collecting the pancreatic juice. Group IV served as control where no parenteral nutriment was administered. The amount, pH, protein and enzyme levels of the pancreatic juice secreted during 4 hours were studied in all groups. The experiments revealed that parenteral nutrition at the initial segment of the jejunum enhanced pancreatic secretion, while this was not experienced in the other groups. The effect is assumed to be humoral, rather with a secretin-like stimulation. Based on the experimental results, the authors call attention to the fact that, during treatment of acute pancreatitis, if a feeding enterostomy is constructed for calorie intake, it should not be performed within the first metre of the jejunum.

Animals↗
PubMed1990

Experience obtained during liver resections made under experimental conditions by a telescopic compressor (AKE).

Liver resection experiments in dogs made by the AKE telescope compressor are reviewed. It is established that the instrument can be applied to the liver parenchyma of varying size and compressibility. The time of resection is short and the intervention entails only minimal loss of blood. Using this solution, it is not necessary to produce the transitory warm ischaemia of the liver.

Animals↗
PubMed1990

Partial splenectomy performed by a special technique in dogs.

Closure of the splenic surface is solved at splenectomy by placing a raw of sutures using a double thread inserted at the same level by two straight needles. This technique does not require interpositions with a good haemostasis and so favours wound healing. It does not need many instruments and is easy to perform.

Animals↗
PubMed1989

[Heterotopic autotransplantation of the spleen in animal experiments].

A new technique of heterotopic autotransplantation of pieces of the spleen is suggested. It differs from the methods used previously in that the pieces of the autologous transplant are placed between the layers of the greater omentum and not on its surface. Not only was the viability of the pieces of the autologous transplant maintained but the hazard of intraabdominal adhesions and their unfavourable consequences was reduced to a great measure.

Animals↗
PubMed1987

Experimental study of autologous free omental grafts.

The fate of intraabdominal free omental grafts was studied in 15 dogs and it was found that a connection between the hollow organ and the transplanted omentum was established only when the former had been injured. The larger, pigeon-egg-sized free fatty omental grafts became necrotic already from the fourth day onwards being replaced by an abscess-like structure, while in thin membrane-like grafts tissue necrosis due to the creeping in of connective tissue was less marked. In both cases, an intact, omentum is creeping over the graft from the adjacent region, i.e. the ultimate covering is actually provided by the pedicle graft.

Animals↗
PubMed1986

Data on renal hypothermia by the venous passage.

The temperature values obtained in renal hypothermia through the venous circulation were biometrically analysed. It was found that there could be even about 4 degrees C temperature differences between the lower and upper poles of the kidney, always as large as 4 degrees C could be elicited in the first five minutes of hypothermia, the lower pole being colder. Similar but smaller differences were observed in ten minutes' hypothermia.

Animals↗
PubMed1986

Combined use of bioplast and tissue adhesive in experimental nephrectomies in in situ renal hypothermia.

In transvenous regional hypothermia wedge-shaped and flat lower pole resections were made in dogs. The cut surface of the kidney was covered by the combination of tissue adhesive and bioplast without sutures. It was found that the polymerization time of the tissue adhesive almost doubled. The usual rigidity of the adhesive was more expressed than in normothermia and it was not influenced by re-heating. Recovery conditions were more favourable; a larger portion of the parenchyma could be preserved than with the traditional closure with needle and thread.

Animals↗
PubMed1985

Experimental in situ renal hypothermia through the renal vein.

The authors worked out the technique of in situ renal hypothermia in dogs by direct cannulation of the renal vein or through the internal spermatic vein (ovarian vein). The technique is suggested for preventing the ischaemic impairment of the renal parenchyma in operations requiring compression of the renal artery for more than 20 minutes.

Animals↗
PubMed1984

Experimental study of suture materials placed in the renal parenchyma.

Absorbable and non-absorbable suture materials in the renal parenchyma were examined in comparative studies performed on 12 mongrel dogs. Quantitative and qualitative histological studies showed that Dexon was preferable to other absorbable suture materials as opposed to traditional catgut, while Supramide and Polyester had certain advantages over other non-absorbable materials.

Absorption↗
PubMed1983

Sutures inserted into the gastric wall an experimental study.

Thirty gastrotomies were performed in 15 dogs using 2/0 atraumatic needles. Various kinds of threads were used: Dexon as an absorbable suture, Black Perlon and Black Braided Silk as nonabsorbable sutures. Ten suture rows were made with each material. Single-row interrupted sutures were made with no suture in the mucosa. No suture insufficiency occurred. Dexon proved to be the most suitable material, although the nonabsorbable sutures did not cause complications, either.

Animals↗
PubMed1983

Comparative studies with extracorporeal hypothermal kidney perfusion.

Various solutions of extra- and intracellular, or non-electrolyte type supplemented with papaverine or lidocaine were administered by gravity perfusion to 60 dog kidneys. Cooling in the kidneys perfused with the solutions containing papaverine lowered the temperature of kidneys in significantly shorter time than in those containing lidocaine. The histological examinations revealed good perfusion with solutions containing papaverine; even the rim of the cortical substance has been freed of blood. Identical results could not be achieved with lidocaine. These results are to be considered in the clinical work.

Animals↗