Biomedical subjects
Publications and source records attributed to I G Dutkevich.
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In the paper the authors are making an analysis of the courses of hemotransfusion complications and recommend a system of measures to prevent them.
The authors made an analysis of results of examination of 41 patients with ischemic heart disease treated by the standard medicamentous therapy and when using different methods of photohemotherapy against its background. It was established that medicamentous therapy during 2 weeks failed to result in a substantial improvement of rheological properties of blood, while its combination with photohemotherapy could give a considerable positive effect coinciding with clinical improvement of the patient's state. Shorter terms are required to correct hemorheological indices when autotransfusions of photomodified blood are used.
The effectiveness of a suspension of erythrocytes in the new colloid preservative "Modegel" (in 1:1 ratio) was studied in the complex treatment of 31 patients with severe gastroduodenal bleedings. It was established that the hemodynamic, antianemic action of the suspension was not inferior (and even excels) to the action of the whole preserved blood and the erythrocytic mass. The suspension transfusion has a favorable effect upon functions of the liver and kidneys, corrects the acidic-alkaline state of the recipients' blood, decreases the lipid peroxidation and has detoxicating properties. During transfusion of the suspension hypocoagulation of blood doesn't take place. The temperature reactions following the suspension transfusion are rare. The suspension of erythrocytes "Modegel" deserves wide introduction to clinical practice.
Under study was the influence of different regimens of blood photomodification on the course of the tumor process. Experiments were carried out on 460 syngeneic mice with a model of Lewis adenocarcinoma of lungs and melanoma B 16. It was established that the influence of APMB on the course of the tumor process is dose-dependent and when specially selected the regimen of APMB may have an antitumoral effect. The transfusion of the photomodified donor blood may facilitate the suppression of antitumoral immune reaction of the recipient organism.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
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It was shown in 31 samples of donor blood containing HBsAg that independent of the irradiation dose HBsAg was not detected in 66.7% of the photomodified blood when using short wave UV radiation. Long-wave UV radiation provides disappearance of HBsAg in 50%. A conclusion is made on expedience of irradiation of the donor blood with ultraviolet rays before transfusion.
The article describes an experience with performing 400 hemosorptions and 271 plasmaphereses under stationary conditions and out of the department. The optimum variant of their organization in surgical practice is proposed.
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Based on their personal experience and analysis of literature data the authors elucidate the significance of achievements of the present-day immunohematology in surgical practice: in blood transfusion, allotransplantation, the connection of surgical diseases with group antigens of blood.
The authors studied the influence of daylight upon peroxidase activity and lipid content in neutrophils by means of cytochemical reactions in blood smears. In the experimental series of studies the blood was taken and stored without daylight. Control blood samples were kept under normal conditions. The studies have shown daylight to be a potent activator of redox processes and lipid metabolism in neutrophils. Similar effect upon peroxidase activity and lipid content in neutrophils is exerted by one calculated dose of long-wave UV rays, two doses inhibiting these processes. Taking and storing blood without daylight contributes to longer valuable morphological and functional condition of the formed elements.
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A study was made of the structural and functional state of the erythrocyte surface components of patients with ischemic heart disease, and of patients with ulcer disease during the treatment with UV-irradiated blood autotransfusions. The cytochemical and isoserological methods employed showed some structural disturbances in the state of erythrocyte, glycocalyx and its modification in the course of treatment. The clinical results of treatment correlated with these changes.