Biomedical subjects

I G Haynes

Publications and source records attributed to I G Haynes.

14 recordsLinked to original sources

PubMed1993

How long do patients convalescence after inguinal herniorrhaphy? Current principles and practice.

Over the course of this century it has become apparent that there is no longer any rationale behind the old-established advice to rest for several weeks after hernia repair. It was our impression that such advice continues to be widely accepted, and we therefore sent questionnaires to 100 recently appointed consultant surgeons, 400 of their patients and 200 recently established partners in general practice to assess current practices. Our findings show that surgeons advised a mean of 4.4 weeks off work and GPs 6.2 weeks off-work, in both cases the period varying with the nature of the patient's occupation. Patients actually took a mean of 7.0 weeks off work. The wide variation reflects the lack of evidence that an early return to work after hernia repair causes any detrimental effect. We believe that this should be explained to patients, who should be free to return to work as soon as they feel comfortable. Such a policy could substantially decrease the current loss of productivity.

Convalescence↗

PubMed1990

Axonal damage in Crohn's disease is frequent, but non-specific.

We have attempted to confirm the claim by Dvorak and Silen that 'Crohn's disease is accompanied by a severe and extensive necrosis of gut axons...[which] may serve to differentiate Crohn's disease from other inflammatory conditions'. In this electron microscope study the diagnoses were withheld until the assessment of axonal damage was completed. We assessed the axonal damage in ileostomy biopsies in 13 cases of Crohn's disease, four cases of ulcerative colitis, and two 'controls'. In Crohn's disease we found a mean per cent of abnormal axons of 29.85, in ulcerative colitis of 21.25 per cent, and in the two 'controls' of 12.11 and 10.63 per cent, respectively. The difference between the 13 cases of Crohn's disease and the six cases of non-Crohn's disease is not significant. We found considerable numbers of abnormal, very small axons of uncertain nature but probably related to regeneration following surgery. Including or excluding such axons did not significantly alter the incidence of abnormal axons. We conclude that axonal damage is common in chronic inflammatory bowel disease and is not specifically related to Crohn's disease.

Axons↗

PubMed1989

Is oleic acid the thyroxine binding inhibitor in the serum of ill patients?

The possibility that oleic acid is the thyroxine binding inhibitor in the serum of seriously ill patients was investigated. 3H-Oleic acid was shown to bind directly to human thyroxine-binding globulin (TBG) by the techniques of one and two-dimensional immunoelectrophoresis in combination with autoradiography. However, no correlation was seen between serum thyroxine concentration and oleic acid concentration in two groups of patients, one of which underwent routine cholecystectomy, whilst the other group was admitted to an intensive therapy unit (mortality 75%). No correlation was seen between serum total thyroxine concentration and either stearic, palmitic, linoleic or arachidonic acid concentrations in these groups. Therefore, it was concluded that oleic acid was unlikely to be the circulating inhibitor of thyroxine binding.

Blood Proteins↗

PubMed1987