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Biomedical subjects

I G Hislop

Publications and source records attributed to I G Hislop.

At least 19 recordsLinked to original sources
PubMed1980

Effect of very brief psychotherapy on the irritable bowel syndrome.

The relationship between emotional factors and abdominal dysfunction in the irritable bowel syndrome (IBS) has been the focus of uncertainty. In support of an integrated psychophysiological basis for the disorder, 60 consecutive IBS patients were treated by psychotherapy. Of the 52 subjects who responded to a self-assessment questionnaire, 46% indicated that they were asymptomatic or had only mild persistence of their symptoms. Only 11 patients (22%) indicated little or no improvement. These results support the efficacy of a very brief, but active, interview designed to contact and release subconscious feelings of distress in patients with IBS.

Adolescent↗
PubMed1980

Dermal necrosis following coumarin: is it immunologically induced?

Two patients with dermal necrosis due to anticoagulation therapy with warfarin are reported. Both patients demonstrated some disturbance in immunological function. It appears possible that warfarin may act as a hapten in the induction of hypersensitivity to the drug. It is recommended that future cases should be studied to determine whether there is a defect in immunoregulation, and whether circulating immune complexes are responsible for the typical skin lesions.

Aged↗
PubMed1979

Childhood deprivation: an antecedent of the irritable bowel syndrome.

Three hundred and thirty-three consecutive patients with irritable bowel syndrome (IBS) were interviewed. By the age of 15 years, 31% of the patients had either lost a parent through death, divorce or separation; 19% had an alcoholic parent, and 61% reported unsatisfactory relationships with, or between their parents. The findings support the important influence of childhood deprivation in the aetiology of IBS.

Adolescent↗
PubMed1977

Elevated serum alkaline phosphatase level may aid in the diagnosis of pancreatitis.

Ten cases of pancreatitis with elevated serum alkaline phosphatase (SAP) levels are reported. Patients with chronic or relapsing pancreatitis may at times develop increased SAP levels, either with or without definitive biochemical evidence of pancreatic disease. SAP estimation may assist in establishing a clinical diagnosis in cases of abdominal pain in which pancreatitis is suspected.

Acute Disease↗
PubMed1976

Bleeding mucosal lesions in the upper gastrointestinal tracts of patients with oesophageal varices and hepatic cirrhosis.

Thirty panendoscopic examinations were carried out on 24 patients with oesophageal varices and hepatic cirrhosis who presented with gastrointestinal hemorrhage. A mucosal lesion, focal or diffuse, was found in the upper gastrointestinal tract in all but three instances. The findings confirmed previous reports that hemorrhage in patients with oesophageal varices frequently occurs from a source other than variceal. This study has also demonstrated that where hemorrhage occurs from oesophageal varices, erosions of the oesophageal mucosa may play a major role in its pathogenesis.

Adult↗
PubMed1975

Haemobilia from pancreatic cystadenoma.

Hamobilia from a pancreatic source is a rare cause of gastrointestinal haemorrhage. Most of the reported cases have arisen from haemorrhage into a pancreatic pseudocyst, which is frequently fatal. This report describes a patient with gastrointestinal haemorrhage arising from a pancreatic cystadenoma.

Bile Ducts↗
PubMed1975

The rectal administration of lactulose.

A lactulose colonic washout (pH 4.5) was administered to six male patients with portal systemic encephalopathy. Estimation of blood ammonia levels and electroencephalography were performed before and after each treatment. Five patients recorded a significant fall in blood ammonia level as a result of lactulose therapy (P less than .025). In the sixth subject, an enema with buffered physiological saline, pH 4.5, induced a fall in ammonia which was not increased by subsequent lactulose solution. Improvement in the electroencephalogram was recorded in all periods where a lactulose colonic washout produced a fall in blood ammonia level.

Aged↗
PubMed1973

Histological changes in the gastric mucosa of chronic gastric ulcer patients treated with carbenoxolone.

Serial direct vision gastric mucosal biopsies were obtained in 25 patients with a chronic lesser curve gastric ulcer. Morphological changes were assessed ;blind' in 15 patients who received carbenoxolone and in 10 untreated patients. Chronic gastritis was initially observed ;proximal' and ;distal' to the ulcer in 24 of the 25 patients. The mucosal changes were shown to persist in subsequent biopsies and appeared to be uninfluenced by therapy with carbenoxolone even when the ulcer had healed.

Adult↗