[Oxyferriscorbone: anti-ulcer effect and its possible mechanisms].
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Biomedical subjects
Publications and source records attributed to I G Kuznetsov.
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The data obtained showed that the polysaccharide diminished the blood levels of cholesterol, beta-lipoproteins, and triglycerides, the concentrations of cholesterol in the liver and thoracic aorta in experimental atherosclerosis. It is concluded that the polysaccharide is promising in designing a new anti-atherosclerotic drug.
It is shown that the level of DNA, RNA, collagen, non-collagen proteins, hexoses and glycosaminoglycans is changed when making the experimental gastric ulcer in rats. Solcoseryl stabilises the level of DNA, RNA and collagen, stimulating the reparation processes in ulcer.
It was shown that isoproxihermatran (IPH) (40 mg/kg) administered intraperitoneally in rats with lobectomy of heparin stimulates development of hepatocytes' dimensions and decrease of oxygen transmission velocity through the mitochondrial membranes in this cells. Antioxidant properties of IPH have been detected. Stimulating activity of IPH at heparin secretion of bile.
The stimulatory action of Bacillus mucilaginosus exopolysaccharide on proliferative processes in experimental gastric ulcer healing. With the drug, the levels of collagen, noncollagen proteins, glycosaminoglycans, DNA, and RNA in the ulcer tissue.
The study investigated a stimulating effect of tris-[2-hydroxyethyl] ammonium salt of iron-containing polyacryl acid on proliferative processes in the connective tissue in development of experimental gastric ulcer. The drug was found to exhibit an ulcerostatic effect, to change the levels of collagen, noncollagen proteins, glycosaminoglycan fractions, DNA and RNA.
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A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.
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The unit activity in the hippocampus formation under the effect of pyracetam was found to depend on the latter dose in rabbits. The ligand-receptor interrelationship with pyracetam seems to exist at the level of the hippocampus formation.
In the experiments on rabbits with experimental atherosclerosis the authors revealed lipolytic and antisclerotic effect of the above drug. It was also observed that it also possessed anticoagulation activity.
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