Biomedical subjects
I G Mediero
Publications and source records attributed to I G Mediero.
Isolated multiple congenital epithelioid blue naevus.
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Malignant atrophic papulosis in an infant.
We report a 7-month-old girl with malignant atrophic papulosis (Degos' disease). She also showed spontaneous aggregation of platelets. A good clinical response was obtained by treatment with aspirin and dipyridamole.
Progressive macular leucoderma in a patient with congenital ichthyosiform erythroderma.
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[Thyroid carcinoma with lung metastasis].
Thyroid carcinoma is a rare disease in children. Much rare its presentation with pulmonary metastases is. We here report a recent case in 12 years-old girl. We make a review of recommended treatment and the prognosis.
Osteoid osteoma with a multicentric nidus.
A case is reported of a 16-year-old boy who presented with continuous pain in his right leg. Cortical thickening and diffuse medullary sclerosis was revealed on x-ray of the distal tibia. CT imaging showed a circumscribed annular pattern extending some 2.5 cm-s and indicating the multifocal nature of the lesion. The diagnosis of multifocal osteoid osteoma was confirmed after histological examination of the block of resected bone.
[Cutaneous polyarteritis nodosa].
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Costello syndrome.
Costello syndrome is an uncommon multisystemic condition with highly characteristic cutaneous manifestations. We describe here the case of a patient with Costello syndrome, and review previous reports of this entity.
Caseating cutaneous granulomas in a child with common variable immunodeficiency.
Cutaneous, noninfectious, granulomatous lesions have been reported occasionally in different types of immunodeficiencies, including common variable immunodeficiency (CVD). We present a child with CVID and cutaneous granulomas with a strikingly prominent caseating necrosis. We think that such granulomatous lesions constitute a distinctive manifestation of immunodeficiency, and may reflect a altered immune response. Corticosteroids have been of benefit to our patient, as well as in similar cases.
Keratosis lichenoides chronica in a child.
A young boy developed childhood keratosis lichenoides chronica. The eruption cleared spontaneously after 13 years. This is a rare condition, regarded by some as a variant of lichen planus. The great preponderance of cases occur in adults, whereas the disease in childhood is uncommon.
Urticaria pigmentosa: a review of 67 pediatric cases.
Mastocytosis is a disorder of mast cell proliferation that may appear during infancy, childhood, or adulthood. We studied 67 consecutive patients (33 males, 34 females) with urticaria pigmentosa and assessed them fully to determine the presence of systemic involvement. Ages at onset of lesions ranged from birth to 11 years, with most developing in the first year of life. Pruritus was the primary symptom. Hematologic and serum chemistry profile, radiologic skeletal surveys, and bone marrow aspirations were performed. Slight anemia was present in three patients. Radiologic bone lesions were observed in eight. Bone marrow aspirates showed slight changes in six patients, with only an increased number of mast cells in an additional patient. The disease tended to resolve spontaneously. This prospective study emphasizes the benign nature of pediatric urticaria pigmentosa.
Lichen scrofulosorum.
A 12-month-old boy with pulmonary tuberculosis developed a papular lichenoid eruption which showed epithelioid granulomas on histology, consistent with lichen scrofulosorum. Stains and cultures for mycobacteria in the skin were negative, and a polymerase chain reaction (PCR) analysis failed to detect the DNA of Mycobacterium tuberculosis in a skin biopsy specimen, thus making lichen scrofulosorum one of the remaining manifestations of M. tuberculosis infection in which evidence of the bacillus has not been found to date. Lichen scrofulosorum is now considered a rare form of tuberculid but should not be neglected.
A cutaneous eruption from G-CSF in a healthy donor.
A healthy 12-month-old donor treated with G-CSF for collection of stem cells from peripheral blood developed a discrete, papular, erythematous eruption which histologically showed irregularly shaped lymphocytes with mitoses. We suggest that such a reaction is due to activation of lymphocytes by G-CSF in a normal host, leading to atypical changes in cellularity.
Primary cutaneous Mycobacterium kansasii infection in a child.
A 6-year-old girl with a primary cutaneous form of Mycobacterium kansasii infection is presented. Disseminated infection and immune deficiency were excluded in our patient. She was successfully treated with surgical excision and oral erythromycin. Primary cutaneous M. kansasii is an exceedingly rare infection in children.