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Biomedical subjects

I G Ursov

Publications and source records attributed to I G Ursov.

At least 19 recordsLinked to original sources
PubMed2003

[On early transfer of new cases of pulmonary tuberculosis to outpatient treatment].

Based on 228 clinical cases, the authors propose procedures for complex two-stage (inpatient and outpatient) treatments of new cases of pulmonary tuberculosis by using intermittent intravenous chemotherapy that makes it possible to have a high therapeutic effect in a short space of time, to reduce the duration of hospital treatment substantially, to on the average 2-4 months, and to ensure controlled chemotherapy at the outpatient stage.

Adult↗
PubMed2000

[Reactions of delayed hypersensitivity in patients with tuberculosis in its dormancy and pandemic].

Comparison of the results of tuberculin diagnosis in patients with tuberculosis during two studies made by the same procedure in 1973 and 1998 showed a marked increase in delayed hypersensitivity, which is indicative of higher sensitization in persons inoculated with Mycobacterium tuberculosis. This appears to be associated with the higher frequency and spread of exogenous reinfections and with the increased virulence of the causative agent.

AIDS-Related Opportunistic Infections↗
PubMed1998

[Treatment of newly diagnosed patients with infiltrative and disseminated pulmonary tuberculosis].

To enhance the efficiency of treatment in new cases of infiltrative and disseminated destructive pulmonary tuberculosis, an intermittent (twice daily) regimen of intravenous dropwise administration of three drugs (isoniazid, rifampicin, PASK) was proposed. The immediate results of clinical observations suggest that intermittent 3-drug intravenous chemotherapy supplemented by collapse therapy in some indicated cases, provides a high control over the therapy, sparing drug load, good tolerance, and rather high efficiency: elimination of destructions in 81.4% (mean 4.2 months), cessation of bacterial isolation in 88.9% in the early (2.2 months) period.

Adolescent↗
PubMed1997

[Organization of in- and outpatient treatment of new cases of destructive pulmonary tuberculosis].

A system of in- and outpatient treatment of the first detected patients with destructive pulmonary tuberculosis is proposed. The use of various types of intravenous intermittent chemotherapy in patients with focal, infiltrative, and disseminated tuberculosis provides a high efficiency in the inpatient period (the mean time of sputum negativation is 1.6 months, that of destruction closure is 3.1 months) and early (in 2 - 3 months) transfer of these patients to outpatient additional treatment by continuing etiotropic therapy that has turned out to be effective in hospital.

Ambulatory Care↗
PubMed1995

[Lymphogenic introduction into lesser circulation of orally administered rifampicin in standard and liposomal forms].

Pharmacokinetics of water and liposomal suspensions of lipophilic antibiotic rifampicin introduced intragastrically through a tube was studied in experiments on Wistar rats. After administration of water suspension rifampicin concentration reached its peak in all the tissues in 3 hours, lung concentration being 1.6 and 1.9 times higher than blood one. After liposomal suspension administration lymphatic rifampicin concentrations were maximal in 3 hours, while in the lungs and blood they were the highest in 6 hours. It is concluded that oral liposoluble drug enter primarily chyle vessels and via thoracic lymphatic duct directly lesser circulation. Liposomal inclusion of the drug warrants its high concentration in lymphatic system and lung tissue.

Administration, Oral↗
PubMed1995

[Effectiveness of liposomal antibacterial drugs in the inhalation therapy of experimental tuberculosis].

The model of generalized tuberculosis in BALB/c mice was used to compare efficacy of daily and intermittent (2 times a week) regimens of ultrasound inhalation therapy. This employed water-soluble and liposomal dosages of antituberculous drugs. The highest effect was achieved in daily inhalations of liposomal drugs. In spite of the fact that intermittent regime of the liposomal drugs required a 2-fold lowered dosage, its efficacy was not inferior to daily water-soluble drug therapy and was only by 22% less than maximum. High response to liposomal form stems from prolonged persistence of high rifampicin concentrations in pulmonary tissue.

Administration, Inhalation↗
PubMed1993

[The strategy for curing open pulmonary tuberculosis in a short period].

The new approaches to short-term cure of open pulmonary tuberculosis imply intensification of etiotropic therapy with the emphasis on its bactericidal potential, introduction of pneumothorax as early as the treatment week 3, initiation of early surgery. Intravenous drug administration needs breaks in its course to make mycobacteria surviving after the previous dose sensitive to the antibiotics. Such intermittent regimens are beneficial for the patients as they contribute to better tolerance, to reducing total drug dosage, to earlier discharge from hospital for outpatient after treatment. Out of 1190 patients treated for 6.5 months according to the above principles cavern healing was achieved in 1106 (93%).

Aftercare↗
PubMed1990

[The social profile and medical characteristics of a first-time registered patient with tuberculosis of the respiratory organs].

Documentation concerning 307 patients with newly discovered respiratory tuberculosis during 1979-1988 was analysed. The mean age of the patients was 40. Respiratory tuberculosis morbidity among adult men was 5.3 times higher than that among women. More benign forms of the disease were revealed in the latter, which insured 100% cure among them. Half the male patients were smear-positive; 3/4, were alcohol abusers; and 1/3 were kept in reformatory institutions before the onset of the disease. Every second of them was single, thus prone to an unhealthy lifestyle and improper nutrition. 4/5 of the tuberculosis-affected men were heavy tobacco smokers with concomitant chronic bronchitis, and the death of 2% of this number was caused by concurrent lung cancer. The follow-up of 248 men from 1 month to 10 years showed that tuberculosis and other causes, including cancer, underlying diseases and fatal injuries, led to the death of 1 (0.4%) and 9.7% of the patients, respectively.

Adult↗