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Biomedical subjects

I G Zhakov

Publications and source records attributed to I G Zhakov.

At least 19 recordsLinked to original sources
PubMed1990

[20 years of experience in using high-energy electron accelerators].

The authors summed up their 20-year experience in the clinical use of a linear accelerator of electrons and a Siemens betatron (42 MeV) in the Research Institute of Oncology and Radiology, Ministry of Health of the Byelorussian SSR. Comparative advantages and shortcomings of both accelerators and the results of their technical modifications were considered. A section in the paper, devoted to the clinical aspects of tumor therapy, is concerned with the description of a number of methods of irradiation with various types of therapeutic beams, energies, field sizes, directions, various regimens of dose fractionation in time and irradiated volume. Long-term results of radiotherapy with accelerators were assessed and compared with the results of gamma-beam therapy on cobalt units. A conclusion was made that by 1991-2000 the Republic would need 10 medical accelerators.

Cobalt Radioisotopes↗
PubMed1989

[Immune status of patients with malignant melanoma during combined therapy including local ultra-high frequency hyperthermia].

Immune status was evaluated in patients with clinical stage I malignant melanoma randomized to receive either preoperative irradiation (27 Gy) alone or in combination with local microwave hyperthermia (before or after it). Mononuclear, total T-lymphocyte, T-helper, T-suppressor, B-lymphocyte and blood-immune complex levels were assayed. The analysis of immunologic parameters dynamics pointed to beneficial changes occurring in immunoregulating T-lymphocytes in patients receiving hyperthermia as a component of combined treatment.

Adult↗
PubMed1988

[Experience in the development of an automated information retrieval system in roentgenoradiology].

The first version of an automated data retrieval system in radiology, radiobiology and oncology has been developed in the Research Institute of Oncology and Medical Radiology of the Ministry of Health, Byelorussian Soviet Socialist Republic. The system is realized on the basis of a packet of applied programs of an automated document processing system, computerized data-bases of the All-Union Scientific and Technical Information Institute and the ES-1022 computer. The system functions in the following modes: 1--selective propagation of information on 194 fixed requests of users; 2--personal search in the dialogue mode; 3--updating of data files. The use of the automated system made it possible to enhance the effectiveness and quality of document search as compared to conventional forms of operation.

Hospital Information Systems↗
PubMed1987

[Results and prospects for the clinical use of hyperthermia in oncology].

Artificial controlled local and total hyperthermia combined with radio- and/or chemotherapy was used for the treatment of 1211 patients with malignant tumors of different sites. A study of the long-term results of 750 patients showed that the incorporation of hyperthermia in the schemes of combined and multimodality therapy resulted in a significant increase in the 5-year survival of the patients with melanoma, soft tissue sarcoma, breast and rectal cancer.

Breast Neoplasms↗
PubMed1983

[Prognostic factors in megavolt radiotherapy of central epidermoid carcinoma of the lung].

Radical program radiotherapy was provided to 403 patients with inoperable central epidermoid lung carcinoma that does not extend beyond one half of the thoracic cavity. Long-term therapeutic results depend on numerous factors the interrelationships of which cannot be revealed without present-day methods of data analysis. The use of computers (a method of parameter grouping and semi-automatic classification--"teaching without a teacher") made it possible before treatment to approach the level of group prognosis by symptoms; taking into account the time course of symptoms in the process of radiation therapy and after its termination--to reach the level of individual prognosis for 22% of the patients.

Adult↗
PubMed1979

[Split-course radiotherapy of squamous cell cancer of the lung].

The results of a continuous (110 patients) and split course (117 patients) radiotherapy for inoperable central squamous cell cancer of the lung are reported. The study comprised only patients treated radically. A 3-year follow-up showed the following rate of survival in the first and second series: 1 year--52% and 54%, 2 years--29% and 26%, 3 years--18% and 14%, the average survival--16.4 months and 16.1 months correspondingly. However, the split course seems to be more advantageous, since it is better tolerated by patients and the radiation reaction is less pronounced.

Carcinoma, Squamous Cell↗