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Biomedical subjects

I Galadari

Publications and source records attributed to I Galadari.

18 recordsLinked to original sources
PubMed2006

A comparative study between viral isolation and indirect immunofluorescence in the diagnosis of herpes simplex virus.

Fifty patients with oral ulcers were studied clinically and investigated for the detections of Herpes Simplex Virus (HSV) through virus isolation from their lesions (vesicles and ulcers) and detection of the presence of antiviral antibodies (both, IgM and IgG) in their sera using the indirect immunofluorescene (IIF) technique. The results of this study proved that virus isolation is the most reliable method for diagnosis, though the use of antibody serological tests could be a useful adjunct to virus isolation in situations where a rapid laboratory diagnosis is needed. Oral Herpes Simplex virus infection can be viewed, in the main, as a trivial disorder causing patients minor physical discomfort. The prevalence of HSV may be high in innocent infections, as high as 1/3 of the population. However, HSV infection and its complications with troublesome recurrences may make the problem worse. The apparent increase in HSV infection over recent years may be partly due to increased publicity about the disease, the current antiviral treatment, the inclusion of both primary and recurrent cases in clinic follow up and the increased use of viral cultures for diagnosis. The aim of this work is to share in the study of the detection of HSV through virus isolation and detection of antiviral antibodies using IIF technique, as well as the evaluation of the diagnosis by the above mentioned methods.

Adolescent↗
PubMed2006

Contact dermatitis in UAE.

Twenty five cases (22 females) who attended the Dermatology out-patient in Dubai dermatology clinic, U.A.E were entered in this study. All of them complained of hand eczema which was diagnosed as contact dermatitis (C D) of the hands. The closed patch test technique was performed for all of them using the standard European battery containing 22 allergens. The results were interpreted and analyzed using the ICDG mode of interpretation after 48 and 96 hours, respectively. We found that nickel sensitivity represented the most common type of sensitivity in hand eczema in both citizens and expatriates living in Dubai, while parabens of perfumes represented the second common sensitizers. We think that patch testing in case of C D of hand is a very good tool for investigating hand eczema.

Adolescent↗
PubMed2006

Rapid detection of IgM and IgG antibodies to herpesviridae virus.

In this study, the immunoconcepts EA indirect enzyme antibody technique (colorzyme) was used not only for detection of IgG antibodies but also for quantitative detection of IgM antibodies to Herpes Simplex virus (HSV), Cytomegalovirus (CMV) and Epstein Barr Virus (EBV) to diagnose recent iactivei infection. Reference reactive and negative antisera and randomly collected human sera were tested by complement fixation test (CFT) against HSV antigens and tested also by immunofluorescent (IF) and colorzyme Immunoconcepts EA tests. All sera that were negative to HSV, CMV and EBV antibodies by CFT were negative by IF and colorzyme EA tests. All antibody positive sera and reference positive antisera were also positive by IF and colorzyme EA tests with slight variation in antibody titres between CFT and colorzyme test results. Human sera which were negative or IgM positive to HSV, CMV and EBV by ELISA as well as negative and positive reference sera from different diagnostic kits were retested by IF and colorzyme EA for IgM antiviral reactivity results were concordance by the three rests. All incubations in colorzyme test were at room temperature and only an ordinary microscope used in IF test or plate washers and readers needed for ELISA test. The colorzyme immunoconcepts is a simple, rapid and sensitive for viral diagnosis and can be used in any private laboratory.

Antibodies, Viral↗
PubMed2005

Serum levels of the soluble interleukin-2 receptor in vitiligo patients in UAE.

OBJECTIVE: To determine serum level of slL-2 receptor in patients with vitiligo in a population in Al Ain, UAE. DESIGN: This is a prospective, descriptive, hospital based study. SETTING: Al Ain Medical District, Al Ain Hospital, UAE. SUBJECTS: Vitiligo patients seen at Al Ain hospital in 2003. RESULTS: The study was based on 32 patients. The sample consisted 21 males and 11 females. 15 healthy individuals were selected as control group. Serum level of slL-2R were significantly higher in vitiligo patient (112 +/- 129.2) than in healthy control (61.1 +/- 44.3 Pmol/L) P < 0.0001. Patient with short duration of the disease shows higher the serum level slL-2R. CONCLUSION: slL-2R showed significant difference between vitiligo patients and control.

Adult↗
PubMed2004

Prostatic-specific antigen and idiopathic hirsutism in females.

Serum prostatic-specific antigens (PSA) were found recently to be present in several female tissues and fluids. High concentrations of PSA were found in hirsute women in comparison with nonhirsute, as was found in other studies. In our study we measured the level of PSA in 20 hirsute and 10 control subjects by using an IMx machine from Abbot Laboratories (Diagnostic division, Abbot Park, Illinois 60064, USA). The age, BMI, F-G score, duration and family history of hirsutism were recorded for both groups. The results were analyzed by using SPSS. We conclude that there is no significant association between the level of PSA and the presence of hirsutism. Usage of this test as a marker of idiopathic hirsutism needs further evaluation.

Adolescent↗
PubMed2003

Diphenylcyclopropenone (diphencyprone, DPCP) in the treatment of chronic severe alopecia areata (AA).

BACKGROUND: Diphenylcyclopropenone (DPCP) has been reported to be an effective topical immunotherapy of extensive alopecia areata (AA) with highly variable reported results. OBJECTIVE: The purposes of this study were to assess the efficacy, side effects, and adverse prognostic factors in the treatment of alopecia areata with DPCP. METHODS: 21 patients were included in the study with chronic and extensive AA. Patients were sensitized in the beginning with 2% DPCP, and the concentrations were increased gradually beginning with 0.000001% every one to two weeks for a period of 6 months. RESULTS: 15 patients (71.4%) had a complete or partial recovery at the end of the treatment period. Most frequent side effects were erythema at the site of application, pigmentation, and lymph node enlargement. The most important adverse prognostic factors were duration of AA, history of atopy, and presence of nail changes. CONCLUSION: Treatment of AA with topical DPCP is effective. Though the treatment may have some side effects, in most cases they are tolerable and respond well to treatment.

Administration, Topical↗
PubMed1998

Respiratory symptoms and lung function in garage workers and taxi drivers.

The aim of this study was to determine the prevalence of some respiratory symptoms and possible diseases among occupationally-exposed garage workers and taxi drivers. This study involved 158 garage workers and 165 taxi drivers, matched for age, sex, nationality and duration of employment. The mean age of 158 Indian subcontinent garage workers was 34.4 +/- 10.4 years; their mean height and weight were 167.7 +/- 6.6 cm and 72.0 +/- 12.3 kg respectively, and the mean duration of employment garage workers was 8.8 +/- 7.6 years. The mean age of 165 Indian subcontinent male taxi drivers was 34.5 +/- 7.7 years; their mean height and weight were 168.7 +/- 6.1 cm and 71.3 +/- 12.6 kg respectively; and the mean duration of employment was 7.5 +/- 5.4 years. The data on chronic respiratory symptoms showed that garage workers had higher prevalence of symptoms than taxi drivers being significantly greater for chronic phlegm, (p < 0.007); dyspneoa (p < 0.001); and sinusitis (p < 0.03). A higher prevalence of all acute symptoms was recorded in garage workers than in taxi drivers, although the differences were significant only for throat (p < 0.02), hearing problems (p < 0.002); nose (dryness, bleeding and secretion) (p < 0.008); and low back pain (p < 0.05). Almost all forced spirometric tests in the exposed garage workers were lower than in taxi drivers. The results of stepwise multiple regression analysis showed that only phlegm, sinusitis, hearing problems, nasal catarrh, throat, low back pain, smoking and FEF25-75, variables were statistically significant predictors as risk factors. In conclusion, the present study suggests that a high prevalence of respiratory symptoms is associated with exposure to motor vehicle exhaust emission in garage working places. Long-term working as garage workers in the United Arab Emirates (UAE), may be associated with the development of chronic respiratory symptoms and have effects on their daily life and health.

Adult↗
PubMed1997

Serum IgE level and clinical allergic diseases in the United Arab Emirates.

OBJECTIVE: To determine the serum IgE level in population and its association with allergic diseases in Al-Ain, United Arab Emirates (UAE). DESIGN: This is a prospective descriptive hospital-based study. SETTING: Al-Ain Medical District, Tawam Hospital, United Arab Emirates. SUBJECTS: Patients who were seen at Tawam Hospital for skin, allergic and respiratory diseases during 1996. RESULTS: The study was based on 228 patients. The sample consisted 95 (41.7%) males and 133 (58.3%) females. The mean and standard deviation of age were 25.89 +/- 15.87 years with range 1 and 72 years. The present study revealed that there were no statistically significant differences between serum IgE level and age groups, gender, clinical diagnosis and respiratory symptoms (p > 0.05). Of 59.2% of patients clinically diagnosed were possible IgE related. There was statistically significant differences between serum IgE level and cut (p < 0.030). There was a positive correlation between clinical diagnosis and cut. CONCLUSION: Consistencies and discrepancies between our findings and those from other studies with respect to allergic diseases and IgE level which support the hypothesis that allergic diseases are a multi-factorial diseases related to both familial and environmental influences.

Adolescent↗
PubMed1997

Clinical and immunological studies in vitiligo in the United Arab Emirates.

OBJECTIVE: To determine the clinical and immunological changes encountered in patients with vitiligo in Al-Ain population, United Arab Emirates (UAE). DESIGN: This is a prospective descriptive hospital-based study. SETTING: Al-Ain Medical District, Al-Ain Hospital, United Arab Emirates. SUBJECTS: Patients who were seen at Al-Ain hospital for skin diseases during 1996. RESULTS: The study was based on 65 patients. The sample consisted 32 (49%) males and 33 (51%) females. The mean and standard deviation of age for males were 38.6 +/- 13.5 years and for females were 35.1 +/- 15.9 years. Most of the patients were UAE, Omani and Pakistani nationals. Positive family history of vitiligo was found in 19% of the patients. Association with other immune diseases was found in 6% of the patients while one or more organ specific antibodies, all of whom were females, most of them had positive history of autoimmune diseases. CONCLUSION: Vitiligo is more common among UAE nationals since the UAE community including a multi-national society.

Adolescent↗
PubMed1996

Serologic tests for treponematoses in the United Arab Emirates.

BACKGROUND AND OBJECTIVE: Venereal syphilis is uncommon in the United Arab Emirates (UAE) and other Gulf states in the Middle East. Although nonvenereal syphilis (bejel) has been reported to be endemic in some of these countries, the extent of treponematoses in the UAE is unknown. The objectives were therefore, to investigate those who attended the outpatient clinic of a hospital in the UAE and to establish the seroprevalence of treponematoses and related clinical conditions. METHODS: One thousand and eighty-four patients were serologically screened with a Rapid Plasma Reagin (RPR) and Treponema pallidum hemagglutination (TPHA) tests. The charts of seropositive and seronegative patients, matched for age and sex, were reviewed and compared for clinical problems. RESULTS: A total of 47 people tested had antitreponema antibodies. The positivity rates varied considerably and rose with age from 0.36% for persons < 16 years to 8.3% for those > 50 years. Among the seropositive group, there were no obvious clinical signs of bejel on presentation, but osteoarthritis was significantly more common than in the seronegative group. CONCLUSIONS: In the UAE, although venereal syphilis is uncommon, there is a high seropositivity rate in the > 50-year age range possibly due to old or attenuated bejel.

Adolescent↗
PubMed1996

Coexistence of atopic dermatitis and lichen nitidus in three patients.

Lichen nitidus (LN) is an uncommon skin disorder. We observed 3 patients with an association of lichen nitidus and atopic dermatitis (AD), which to the best of our knowledge has not been previously reported in the literature. It remains to be evaluated whether the association of LN and AD is fortuitous or not.

Adult↗
PubMed1995

Pets, allergy and respiratory symptoms in children living in a desert country.

The aim of this paper was to study the effect of pets and other domestic animals effect on allergic respiratory symptoms among United Arab Emirates primary school children. A cross-sectional survey of 2200 school children living in both urban and rural areas was conducted using self-administered questionnaires between November 1993 and June 1994. The age range of the children studied was 6-12 years, with a mean of 9.23 and standard deviation of 2.14 years; 51% were girls and 49% were boys. Pet ownership was defined by the presence of birds, cats, camels, dogs, goats, poultry and rabbits in the home. One thousand and thirty-six (1036/2090 = 49.6%) of the 2090 families studied had at least one animal at home. However, respiratory symptoms, pet allergy, chronic cough, chronic wheeze, breathlessness or chest tightness, doctor-diagnosed asthma, rhinitis and eczema was reported by 633 families (30.3%) from 2090 studied families. The highest prevalence of reported respiratory allergy and symptoms was found in children who had pets in the past and currently. The lowest prevalence of reported respiratory allergy and symptoms was found in children who never had pets in their lives. Past pets ownership was generally associated with a higher prevalence of pets allergy and respiratory symptoms. No less than 218 (10.4%) reported removing pets in the past because of an allergy or other health problems in the child or in other family members. The risk of having pet allergy in children with animals was found to be twice than that of children without (RR: 2.13; 95% CI: 1.53-2.97; p < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

Allergens↗
PubMed1993

Epidermodysplasia verruciformis: report of a case with palmar pits.

A case of epidermodysplasia verruciformis is reported. This rare disease is characterized by a generalized eruption of flat warts and lesions resembling pityriasis versicolor. Epidermodysplasia verruciformis is considered to represent a distinctive pattern of abnormal reactivity to the human papillomavirus. Our patient, in addition to showing the classic skin lesions, exhibited pitlike lesions of the palms.

Adult↗
PubMed1992

Tinea versicolor: histologic and ultrastructural investigation of pigmentary changes.

A comparative histopathologic study is made between the hypopigmented and hyperpigmented skin lesions of pityriasis versicolor and normal skin areas utilizing histochemical stains and electron microscopy. There were no differences found between the population of Dopa-positive melanocytes within the hypopigmented and hyperpigmented lesions and the normal skin areas. The total epidermal pigmentation was diminished in hypopigmented lesions. The keratin layer was found to be significantly thicker in hyperpigmented lesions and contained more organisms. In hypopigmented lesions, melanocytes contained fewer and smaller melanosomes and exhibited signs of degenerative cellular changes.

Cell Count↗