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Biomedical subjects

I Garborg

Publications and source records attributed to I Garborg.

4 recordsLinked to original sources
PubMed1990

[Malignant and premalignant lesions of the uterine cervix. Cytologic contribution to the diagnosis].

A retrospective investigation covering the period 1980-84 showed that in 552 women the histological diagnosis was invasive or pre-invasive (CIN-III) lesion of the uterine cervix. The role of cervical cytology in the diagnosis was evaluated. Cytological smears had been taken from only 34% of women with invasive lesions as compared with 89% of women with pre-invasive lesions. False negative cytological diagnosis was submitted in 7%. In 38% of the patients the cytological smears brought to light less advanced changes than did the subsequent histological examination. Lack of endocervical cells in the smears gave less reliable material than when endocervical cells were present. The investigation gives grounds for the following recommendations: Women over the age of 45 should take greater advantage of the offer of having cervical smears taken. Women with even mild cytological changes must be controlled particularly if there are no endocervical cells present. Lack of endocervical cells in the smears should be reported. Cytological laboratories should send written reminders if requested repeat-smears or biopsies are not received.

Adult↗
PubMed1987

Congenital neuronal ceroid lipofuscinosis. A case report.

A case of congenital neuronal ceroid lipofuscinosis, a 9-day-old male child of Pakistani parents, is reported. Only 5 congenital cases have been described previously. The cerebral and cerebellar cortex showed extensive nerve-cell loss. Granular material with histochemical characteristics of ceroid-lipofuscin was deposited in neurons, macrophages and glial cells throughout the brain. Similar material was found in macrophages in the lymphoid system and in certain other organs. Ultrastructurally, the material was identical with that described in the infantile type of ceroid lipofuscinosis. It is pointed out that the metabolic exchange between the blood of the mother and the foetus is not sufficient to prevent the intra-uterine progression of the disease.

Brain↗
PubMed1985

The probability of overlooking prostatic cancer in transurethrally resected material when different embedding practices are followed.

When all transurethrally resected material of 53 subsequent patients was microscopically examined, primary adenocarcinoma of the prostate was found in 18 patients and benign disease in 35. Only 9 of the patients with histologically confirmed malignancy of the prostate were clinically diagnosed. The proportion of prostatic chips that contained malignant tissue ranged from 1-96%. A mathematical analysis evaluating the probability of including a carcinoma when different numbers of blocks were processes was performed. The analysis showed that when the patient has a clinically malignant diagnosis the probability of 100% is reached by the processing of one block. If the patient has a clinically benign diagnosis, however, the probability of 98% is first reached by the processing of 8 blocks, if such an amount of material is available.

Adenocarcinoma↗