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Biomedical subjects

I García

Publications and source records attributed to I García.

201 records · Page 12Linked to original sources

[Lymphoepithelioma of the pharynx in children].

Through a period of thirteen years, eleven patients with pharyngeal lymphoepithelioma were treated at the Hospital Nacional de Niños, San José, Costa Rica. This represents 2.5% of all malignant tumors observed in the same period. Histologically, 10 cases were of the type described by Regaud and only one was of the Schmincke's type. Four patients were treated with cobalt only and the other seven received Co60 plus chemotherapy. Two patients of the first group are alive and without evidences of tumor 96 months later. Four of the seven patients of the second group have been incomplete remission for 5, 9, 24 and 96 months. All the patients who had partial remission and all those who relapsed died because of infiltration to the basis of the skull and/or metastases to long bones. All patients who had complete remission and did not have a relapse through a 24 month period, are alive and without evidences of tumor. Metastases to cervical lymph nodes at the moment of diagnosis did not influence the response to treatment or the prognosis. Three out of 5 patients with infiltration to the basis of the skull at the initial examination died. The other two are alive at 9 and 96 months post-treatment.

Adolescent↗

[Usefulness of nuclear morphometry as predictive factor of progression in bladder papillary carcinoma].

Lately, nuclear morphometry methods are being used to analyze the malignant potential of tumoral cells. This paper presents a retrospective study of a series of 163 patients with the three histological grades (WHO), of superficial papillary transitional cell carcinoma (pTa-pT1) of the bladder with a mean follow-up of 60 months. A morphometric analysis of the initial tumour biopsies was made. Mean nuclear area (NA) and its standard deviation (NASD) were measured in a semi-automatic image analyzer (MOP-videoplan, Kontron). NA and NASD show increasingly higher values with increased grade (p < or = 0.0001). NA and NASD values raise in those progressing to muscle-infiltrant stage; tumours were, then, divided into two morphometric groups: small NA (< 50 microns 2) and large NA (> 50 microns 2); the difference between them being statistically significant. The likelihood of no tumoral progression at 30, 60 and 90 months was, respectively, 96, 94 and 92 percent, form small NAs, and 76, 65 and 64 percent for large NA (p < or = 0.0001).

Carcinoma, Transitional Cell↗

Severe graft versus host disease following liver transplantation confirmed by PCR-HLA-B sequencing: report of a case and literature review.

A case of severe graft versus host disease in a liver transplant recipient is presented. Due to HLA similarity between donor and recipient, the demonstration of cellular chimerism had to be made by PCR-HLA-B sequencing. In addition, we review the literature on this entity emphasizing its poor outcome, the difficulty of the differential diagnosis, and the need for the development of new prophylactic and therapeutic strategies in its management.

Adult↗