Biomedical subjects

I Gera

Publications and source records attributed to I Gera.

15 recordsLinked to original sources

PubMed1992

Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone.

The role of resorption in the anabolic response of bone to parathyroid hormone (PTH) is not well understood. In contrast to the increase in bone mass induced by intermittent PTH in intact rats, continuous infusion of PTH into thyroparathyroidectomized (TPTX) rats failed to increase bone volume. The objective of this study were to determine if continuous infusions of low doses of PTH were anabolic in intact rats and if inhibition of resorption would enhance or block an anabolic action of PTH. Young male rats were treated with either continuous infusion or intermittent injections of hPTH-(1-34) for 12 days. In experiment 1, PTH, infused daily at 4 micrograms per 100 g, increased femur calcium and dry weight. Unlike infusion of 8 micrograms PTH, which did not alter bone mass, intermittent PTH at 8 micrograms was anabolic and increased bone mass by increasing trabecular thickness and number. Infusion of 16 micrograms induced hypercalcemia and death. In experiment 2, lower dose daily infusions of 0.25-4 micrograms PTH per 100 g did not increase bone mass. In experiment 3, in rats pretreated with dichloromethylene diphosphonate (Cl2MDP) to inhibit resorption and subsequently exhibiting decreased bone formation, PTH, irrespective of the method of administration, reversed the inhibitory effects of Cl2MDP on bone formation. Thus, intermittent and continuous PTH increase bone formation independently of effects on bone resorption, but only intermittent PTH increases bone mass consistently.

Animals↗

PubMed1992

[The effect of quality dentistry on the condition of the periodontium].

In the periodontal prophylaxis and therapy the most important steps are the adequate professional and individual oral hygienic interventions. Several factors are interfering with our attempts to maintain good oral hygiene either on the individual or professional basis. Among these many are artificially created during dental treatments. In the first part the clinical and experimental data on the effect of bad restorations on the health of periodontium are overviewed. The literature shows that these factors per se do no cause damage to the periodontium but the altered sub- and supragingival plaque accumulation due to these factors are responsible for the pathological conditions. The author deals with the effects of the placing and quality of crown margins, the smoothness of subgingival restorations, the shape and dimensions of interproximal areas, contact surfaces, the shape of pontics and the occlusal surface on the plaque accumulation and on the practice of professional and individual oral hygiene. The periodontal prophylactic philosophy and the standards of quality dentistry as well as the basic principle of periodontal prosthodontics are also discussed.

Dental Care↗

PubMed1991

[Possibilities of reducing the sensitivity of the neck of the tooth].

Authors overview the etiology and pathomechanism of the root hypersensitivity. The most commonly used therapeutical aids and devices are discussed. They discuss the theory of action of the drugs used for controlling root hypersensitivity. In details the dental literature of devices used on the individual bases--included different fluoride compounds, stronciumchloride, and potassium nitrate--are reviewed. In the end the authors's own clinical experience and findings with the Sensodyne toothpaste (kindly donated by the Block Drug Co.) are presented.

Dentin Sensitivity↗

PubMed1991

[Importance of periodic follow up of periodontal diseases for the maintenance of periodontal health and the longevity of dental restoration].

The major objective of the author's investigation was to determine if the progression of attachment loss, the recurrence of active phase of periodontitis and development of new carious lesions can be controlled and prevented in individuals with prior history of aggressive periodontitis provided full mouth reconstruction and maintained at a proper level of oral hygiene. The results of a group on regular periodontal recall program were compared with the five years dental and periodontal findings on a matched group of patients having not been on regular maintenance program. The well maintained group of patients' annual recall data did not vary markedly. In five years basically the same amount of attachment apparatus was maintained. The reexamination of the non recall group at the end of the fifth year shoved a total deterioration of dentition due to the progression of periodontal disease and attachment loss. Especially those of rapidly progressing periodontitis cases shoved 70 to 100% attachment loss. This comparative study attempted to outline the insufficiency of our former dental philosophy of patient management and follow up. Authors emphasize the importance of the follow up, and maintenance of a very high level.

Adult↗

PubMed1990

[The significance of the styloid process syndrome in the differential diagnosis of temporomandibular dysfunction].

Two cases are reported on, both patients came to the clinic on the suspicion of temporo mandibular joint disfunction. Their complaints was caused by overdeveloped processus styloideus. After surgical removal of the processus styloideus the complaints ceased. In cases of seemingly temporo mandibular joint disfunction not improving on conventional treatment the possibility of the processus styloideus syndroma has to be considered.

Adult↗

PubMed1979