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I Gielen

Publications and source records attributed to I Gielen.

2 recordsLinked to original sources

The syllable-length effect in number processing is task-dependent.

Two experiments were run in order to investigate the relationship between syllable length of number names and eye-fixation durations during silent reading of one- and two-digit numbers. In Experiment 1, subjects had to read a series of three numbers and recall them orally; in Experiment 2, subjects had to indicate manually whether the value of the middle number was between the values of the outer numbers. The effect of syllable length was controlled for possible confounding effects of number frequency and number magnitude. Findings indicated that fixation duration depended on syllable length of number names in the first task, but not in the second task. The results call into question the claim that phonological encoding is imperative in visual processing; phonological encoding was used only when the numbers had to be recalled, and not when they were coded for computational purposes.

Adult

RU-486 inhibits rat gonadal steroidogenesis.

RU-486 is a synthetic steroid analogue that can inhibit adrenal steroid synthesis in the rat and rhesus monkey. We measured the activities of five testicular and two ovarian microsomal steroidogenic enzymes to assess the potential effect of RU-486 on rat gonadal steroidogenesis. Hypophysectomized, gonadotropin-replaced rats received RU-486 or a vehicle solution twice daily for seven days. The animals were sacrificed and their gonads were resected, weighed, and microsomal enzyme activities were measured according to RU-486 treatment. Testicular 17-hydroxylase and aromatase activity decreased in RU-486 treated animals whereas 17,20-desmolase, 3 beta-hydroxysteroid dehydrogenase and 17-ketosteroid reductase activities were unaffected. Ovarian 17-hydroxylase but not 3 beta-hydroxysteroid dehydrogenase activity was decreased in the animals receiving the drug. We conclude that RU-486 inhibits both testicular and ovarian steroidogenesis in the rat.

17-Hydroxysteroid Dehydrogenases