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Biomedical subjects

I Gilchrist

Publications and source records attributed to I Gilchrist.

7 recordsLinked to original sources
PubMed1990

Frequency of low-grade residual coronary stenosis after thrombolysis during acute myocardial infarction.

The clinical, angiographic and demographic characteristics of 42 patients with low-grade (less than 50%) residual stenosis at the infarct lesion after thrombolysis for acute myocardial infarction (MI) were assessed. The study group (group I) represented 21% of 198 consecutive patients receiving thrombolytic therapy over a 59-month period. Data on the 156 remaining patients were pooled for comparison (group II). Group I patients were predominantly men (86%) who were cigarette smokers (81%). Group II patients were predominantly men (75%, p greater than 0.10) but were significantly older (52 +/- 12 vs 56 +/- 10 years, p = 0.02). Prior acute MI or angina was unusual in group I. Sixty percent had no significant (greater than 50%) residual coronary artery disease while 25% had residual single artery disease. Average significant (greater than 50% diameter stenosis) residual vessel disease was 0.6 +/- 1.0 for group I and 1.9 +/- 0.9 for group II (p less than 0.001). In group I, average residual infarct lesion diameter stenosis was 36 +/- 7% in the right anterior oblique and 34 +/- 8% in the left anterior oblique views. Thirty-nine group I patients were discharged with medical therapy and 100% follow-up was obtained over a mean interval of 18 +/- 17 months. Fifteen patients experienced chest pain after acute MI accounting for 17 discrete events. Fifty-nine percent of group I had a benign course on follow-up. Eight events were classified as unstable angina, 4 as acute MI and 5 as atypical angina. Documented coronary vasospasm occurred in 3.(ABSTRACT TRUNCATED AT 250 WORDS)

Angina Pectoris↗
PubMed1987

Effects of hydrostatic pressure on the motor activity of fish from shallow water and 900 m depths; some results of Challenger cruise 6B/85.

1. Two species of benthic fish from 900 m depths (90 atm pressure), Trachyscorpia cristulata echinata and Synaphobranchus kaupi, are shown to be adapted to their normal, high ambient pressure. 2. Their condition improves when they are restored to their normal pressure after experiencing decompression in a trawl and they undergo convulsions at 150 atm. 3. This contrasts with the response of shallow water species (Salmo salar, Pleuronectes platessa, Anguilla anguilla and Gadus morhua) which convulse at 93-114 atm and become immobilized and rigid at 150 atm.

Animals↗
PubMed1985

The ionic composition of the plasma and erythrocytes of deep sea fish.

This paper reports measurements of the plasma osmolarities, the main inorganic ions and the concentrations of plasma proteins in nine species of deep sea fish from depths of 900-4,000 m. Chloride and magnesium values are high compared to those of shallow water fish. These ions may be contaminants from sea water either contributing to, or resulting from, the animals' moribund condition. They may also contribute to the failure of isolated erythrocytes to show ionic regulation even after being restored to their normal high pressure.

Animals↗
PubMed1984

High frequency ventilation and gas diffusion.

The efficiency of CO2 removal was studied using a simple lung model with a high frequency positive pressure device (up to 100 b.p.m.) with and without an anatomical deadspace. At a constant minute ventilation without an anatomical dead space, the efficiency of CO2 elimination increased with increasing frequency. However, when a dead space was introduced, the efficiency of CO2 elimination decreased with increasing frequency. Using a high frequency oscillation technique (360 to 900 b.p.m.), it was not possible to maintain a reasonable CO2 elimination with tidal volumes less than the anatomical dead space. In this model there was no evidence that accelerated diffusion was a factor in CO2 removal during high frequency ventilation or oscillation.

Humans↗