Biomedical subjects
I H Pattison
Publications and source records attributed to I H Pattison.
Nasogastric intubation of the horse.
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Oncogenes--implications for human cancer.
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Experimental production of scrapie-resistant Swaledale sheep.
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The establishment of sheep flocks of predictable susceptibility to expirimental scrapie.
A selection experiment, based on a foundation stock of over 700 Herdwick sheep and aimed at producing divergent populations of predictable high susceptibility or resistance to experimental scrapie was begun at this Institute in 1961. Twelve years later, flocks of presumed 100 per cent susceptibility to the Cheviot-dervied scrapie agent SSBP-1 used throughout the experiment, and also manifesting a high incidence of the disease when challenged with other scrapie strains, are used in the Compton scrapie research programme. The highly resistant flocks appear to have a small residual incidence of scrapie cases, often with very long incubation periods. The type of scrapie caused by the SSBP-1 agent is largely under the genetic control of a single pair of autosomal alleles, the dominant allele conferring susceptibility.
Scrapie in sheep selectively bred for high susceptibility.
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A history of the Veterinary Research Club 1924-1974.
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Clinical and histological recovery from the scrapie-like spongiform encephalopathy produced in mice by feeding them with cuprizone.
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Permeability of blood vessels in mice affected with scrapie or fed with cuprizone.
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Unsuccessful attempts to produce disease with tissues from mice fed on a diet containing cuprizone.
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Spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie-affected sheep.
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Histopathological similarities between scrapie and cuprizone toxicity in mice.
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Detection of the scrapie agent in tissues of normal mice with special reference to the possibility of accidental laboratory contamination.
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Clinical and histological observations on cuprizone toxicity and scrapie in mice.
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