The effect of chronic barbitone administration and withdrawal on the sensitivity of the central nervous system to barbiturate.
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Animals↗
Biomedical subjects
I H Stevenson
Publications and source records attributed to I H Stevenson.
Inhibition of hexobarbital metabolism by diethylnitrosamine.
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Animals↗
Hepatic drug-metabolising enzyme activity and duration of hexobarbitone anaesthesia in barbitone-dependent and withdrawn rats.
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Anesthesia↗
Tolerance experiments with barbitone-dependent rats.
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Animals↗
Hexobarbitone response in barbitone-dependent and withdrawn rats.
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Anesthesia↗
Impairment of human drug metabolism by oral contraceptive steroids.
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Administration, Oral↗
Altered plasma protein binding of drugs in thyroid disease.
The plasma protein binding of propranolol and warfarin was studied in vitro by ultrafiltration in hyper- and hypothyroid patients both before and after treatment. The degree of binding of propranolol was significantly decreased in hyperthyroid patients and increased in hypothyroid patients, and was negatively correlated with serum thyroxine and the free thyroxine index. The plasma protein binding of warfarin was also decreased in hyperthyroid patients, but was unchanged in hypothyroid patients. These results suggest that the binding of both acidic and basic drugs may be altered by thyroid disease.
Adolescent↗