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I Hansen

Publications and source records attributed to I Hansen.

78 records · Page 5Linked to original sources
PubMedDate not supplied

Triglyceride hydrolysis of soy oil vs fish oil emulsions.

BACKGROUND: Fish oil triglycerides (TG) are being considered for use in IV lipid emulsions, but the characteristics of their lipase-mediated clearance from plasma are largely unknown. METHODS: We compared the in vitro hydrolysis of soy oil long-chain triglyceride emulsions (LCT) and fish oil emulsions (omega-3) using lipoprotein (LPL) and hepatic (HL) lipases, omega-3 emulsions contained 18% and 28% of total TG fatty acid as eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA), respectively. RESULTS: Under conditions of maximal hydrolysis, total free fatty acid (FFA) release was two- to threefold greater with LCT compared with omega-3 emulsions. Also, EPA and DHA together contributed proportionally much less than other fatty acids (< 20%) to FFA released from omega-3 emulsions. In mixtures of LCT emulsion with omega-3 emulsions, the presence of > 20% of omega-3 particles substantially inhibited LCT emulsion hydrolysis (by up to 50%). CONCLUSIONS: Our results suggest that, during infusion of omega-3 emulsions, EPA and DHA may enter cells as TG or partial glycerides within emulsion particles and not as FFA and that coinfusion of omega-3 emulsion with LCT emulsion at low omega-3:LCT emulsion ratios (up to 20% of total triglyceride as omega-3) will not substantially inhibit LCT hydrolysis.

Docosahexaenoic Acids↗
PubMedDate not supplied

[Effect of megadose vitamin C on osteochondrosis in pigs (author's transl)].

Two experiments with daily supplementation of from 1 g vitamin C pr. pig at 10-12 kg live weight, gradually increased to about 8 g at 100 kg live weight, are described. Experiment I consisted of 9 pigs supplemented with vitamin C on the food once a day, and 9 pigs used as control group. Experiment II consisted of 2 litters, each of 10 pigs. Five pigs from each litter were given vitamin C supplement intramuscularly once a week until 6 weeks of age, thereafter on the food once a day, and the other 5 were used as control group. Incidence and degree of lesions in the elbow joint, in the distal epiphyseal plate of ulna and in the medial condyle of femur were examined after slaughtering. There was no statistically significant difference in incidence or degree of lesions between the comparable groups. However, in experiment I there was a tendency toward less severity of lesions among pigs getting vitamin C (Table I). groups were slaughtered at the same age. The mean slaughter weight was 5.2 kg higher for the pigs which had gotten vitamin C. The difference was not statistically significant.

Animals↗