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Biomedical subjects

I Hashimoto

Publications and source records attributed to I Hashimoto.

At least 217 records · Page 12Linked to original sources
PubMed1987

Somatosensory evoked potentials elicited by air-puff stimuli generated by a new high-speed air control system.

Sharp-fronted air-puffs (a rise-time of 1 msec) generated by the new high-speed air control system were used for eliciting SEPs. This system employs a rotating disk driven by a synchronous electric motor for high-speed control of air flow from a compressed air source. The air-puff is reproducible and its pressure wave form can be varied. SEPs to air-puffs or electrical stimulations of the right hand recorded from the contralateral parietal scalp had similar wave forms, but SEPs to air-puffs showed longer latencies (1-4 msec) and smaller amplitudes than those to electrical stimuli. The amplitude of early components in air-puff SEPs was on average 30% of that in electrical SEPs, but later components reached up to about 90%.

Adolescent↗
PubMed1987

Preovulatory secretion of progesterone, luteinizing hormone, and prolactin in 4-day and 5-day cycling rats.

Timing of ovulation and changes in plasma progesterone, luteinizing hormone (LH), and prolactin (PRL) during periovulatory stages were determined in Holtzman rats exhibiting regular 4- or 5-day cycles under a daily artificial illumination from 0500 to 1900 h. The 5-day cycling rats ovulated between 0130 and 0930 h on estrus, whereas some of the 4-day cycling animals ovulated as early as about 0130 h and others as late as 1130 h on estrus. Onset time of preovulatory LH and progesterone surges was about 1500 h on proestrus in both the 4- and the 5-day cycling rats. Peak levels of plasma LH and progesterone were measured at 1700 to 1900 h on proestrus, while the first rises and peak values of plasma PRL were evident a few hours earlier than those of plasma LH in the rats with two cycle lengths. Plasma LH levels at 1900 h on proestrus as well as plasma progesterone levels at 1600 and 2300 h on proestrus and at 0130 and 0330 h on estrus were significantly lower in the 5-day cycling rats than in the 4-day cycling animals (p less than 0.05). In contrast, PRL levels from 1500 through 2300 h on proestrus remained consistently higher in 5-day cycling rats than in 4-day cycling rats, and significant differences in PRL levels between these rats were apparent at 1500, 1600, and 2100 h (p less than 0.05-0.01). Thus, these results demonstrate that the 5-day cycling rats exhibit the attenuated magnitude of LH surge accompanied by the augmented preovulatory PRL release, and that plasma progesterone levels reflect the magnitude of LH surge. A tentative working hypothesis concerning the etiology of the 5-day cycle has been proposed.

Animals↗
PubMed1987

[Pharmacokinetics of cefmetazole during and after surgical operations].

Cefmetazole (CMZ), with its relatively broad antibacterial spectrum, good stability to beta-lactamases and a high degree of safety, has established a place in the antibacterial therapy. In this study the pharmacokinetics of CMZ during and after surgical operations were investigated. CMZ in a dose of 2 g was administered intravenously to 15 cases operated upon for ailments of abdominal organs (10 cases of cholecystolithiasis and 5 cases of early or resectable gastric cancer). The serum samples were taken during and on the 2nd or the 3rd day after operation. Concentrations of CMZ in serum were measured by bioassay with Micrococcus luteus ATCC 9341 and by a high performance liquid chromatography (HPLC) method. CMZ concentrations during the operation was at higher level than on the 2nd or the 3rd day after the operation. In cholecystolithiasis, the half-life time (T 1/2) was 2.11 hours during operation and 1.42 hours after the operation. In cases of gastric cancer, T 1/2 was 1.31 hours during operation and 2.21 hours after the operation. In cholecystolithiasis, area under the curves (AUCs) were 469.39 micrograms.hr/ml during operation and 294.44 micrograms.hr/ml after the operation. In cancer cases, AUC's were 339.83 micrograms.hr/ml during and 329.75 micrograms.hr/ml after operation. Any postoperative infections and adverse reactions were not observed in these cases. Therefore, CMZ would be very effective and available for its prophylactic role.

Adult↗
PubMed1987

[Clinical significance of a physical activity index based on calorimetry in the assessment of quality of life after total gastrectomy].

In order to characterize the objective diagnostic criteria concerning quality of life (QL) of patients after total gastrectomy, a physical activity index (PAI) or a concept of daily physical activity was developed. Sixty patients of gastric cancer, of whom 38 patients underwent long loop Roux-en-Y gastrojejunostomy (LLRY) procedure after total gastrectomy, 13 patients gastroduodenostomy (Billroth I) and 9 patients gastrojejunostomy (Billroth II) after subtotal gastrectomy, respectively, were evaluated as part of this study. In addition, 3 cases of pancreatoduodenectomy (PD) and 5 cases of total esophagectomy were also evaluated. The evaluation of QL was based upon a clinical assessment and administration of patient questionnaire. The assessment of the PAI was performed by measuring the individual's whole day energy expenditure based upon 24 hour heart rate ratio (24h-HRR) method and the basal metabolic energy expenditure. The daily physical activity was graded into four categories according to the PAI value; light, moderate, moderately heavy and heavy. The results obtained were as follows: The value of the energy expenditure predicted by 24h-HRR method and that based on the results of bicycle ergometry (VO2/HR method) showed close correlation. There was no significant difference in the whole day energy expenditure among four operative procedure groups (Billroth I, Billroth II, LLRY and total esophagectomy). More than 80 per cent of LLRY patients, whose QL was evaluated as "excellent" or "good", showed no less than "moderate" PAI. In addition, one of the four patients whose QL was "fair" was categorized into "light" and the remaining three were "moderate".(ABSTRACT TRUNCATED AT 250 WORDS)

Activities of Daily Living↗
PubMed1987

[Clinical studies on cefuroxime axetil in acute mastitis].

Cefuroxime (CXM), with its relatively broad antibacterial spectrum, good stability to beta-lactamases and high safety, has an established place in antibacterial therapy. However, like many other cephalosporins, its clinical application is rather limited due to the need for parenteral delivery. Recent work has led to the development of cefuroxime axetil (CXM-AX, SN407) which is the 1-acetoxyethyl ester of CXM is well absorbed from the gastrointestinal tract and promptly cleaved to cefuroxime thereafter. CXM-AX, in a dose of 500 mg, was given after meal by oral administration 3 times daily for 5-8 days to 10 lactating outpatients with acute mastitis. Ages of the patients ranged from 26 to 44 years, and body weights ranged from 48.0 to 59.0 kg. Clinical response was assessed as excellent in 2 cases, good in 8 cases and fair or poor in none. No adverse effects were observed. Seven strains of organisms were isolated from 7 cases. They included 5 strains of Staphylococcus aureus and 2 strains of Staphylococcus epidermidis. The MICs of CXM were under 3.13 micrograms/ml with inoculume size of 10(8) and 10(6) cells/ml. In 1 case, CXM concentrations in puruloid milk and in healthy milk were measured by bioassay with Bacillus subtilis ATCC 6633 as the test organism. The CXM concentrations in healthy milk ranged from 0.09 to 0.59 microgram/ml (mean: 0.32 +/- 0.25 microgram/ml) at 30 to 90 minutes after oral administration of 500 mg CXM-AX. The CXM concentrations in puruloid milk ranged from 0.57 to 1.05 micrograms/ml (mean: 0.74 +/- 0.27 microgram/ml).(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMed1986

Lentigo maligna melanoma with deep invasion along the mental nerve.

A case of lentigo maligna melanoma on the vermilion of the right lower lip which invaded deeply along the mental nerve is described. The patient also had sensory loss and numbness in the area innervated by the mental nerve, which was the only sign of this rare mode of invasion in this case. Early excision of the lentigo maligna lesion is stressed, and if the patient complains of sensory disturbances in the area of the lesion, this might be a sign of deep invasion of the tumour along the nerve bundle.

Aged↗
PubMed1986

Changes in plasma progesterone, estradiol, follicle-stimulating hormone and luteinizing hormone during diestrus and ovulation in rats with 5-day estrous cycles: effect of antibody against progesterone.

Progesterone secretion remained significantly higher during diestrus in the 5-day cyclic rat than in the 4-day cyclic animal. Injection of a sufficient amount of antiprogesterone serum (APS) at 2300 h on metestrus in a 5-day cycle advances ovulation and completion of the cycle by 1 day in the majority of animals (75 and 80%, respectively). Progesterone (250 micrograms) administered with APS eliminated the effect of the antiserum. Within 2 h after administration of APS, levels of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) elevated significantly, while a significant elevation of plasma estradiol above the control value followed as late as 36 h after the treatment. None of the 5-day cyclic rats treated with APS showed ovulatory increases of FSH and LH at 1700 h on the second day of diestrus, although 3 of the 4 animals receiving the same treatment ovulated by 1100 h on the following day. The onset of ovulatory release of gonadotropins might have been delayed for several hours in these animals. These results indicate that recurrence of the 5-day cycle is due to an elevated progesterone secretion on the morning of diestrus, and suggest that a prolongation of luteal progesterone secretion in an estrous cycle suppresses gonadotropin secretion. Rather than directly blocking the estrogen triggering of ovulatory LH surge, the prolonged secretion of luteal progesterone may delay the estrogen secretion itself, which decreases the threshold of the neural and/or hypophyseal structures for ovulatory LH release.

Animals↗