PubMed Health⌕ Search

Biomedical subjects

I Haslock

Publications and source records attributed to I Haslock.

At least 37 records · Page 2Linked to original sources
PubMed1986

Measurement of stiffness in the metacarpophalangeal joint: the effects of physiotherapy.

Five common modes of physiotherapy were applied to a group of normal subjects and to a group of patients with rheumatoid arthritis. The metacarpophalangeal joint stiffness was measured before therapy and immediately afterwards and the results compared. The only statistically significant result was that short-wave diathermy and ultrasound both reduced the amount of energy dissipated in the joints of the patients. No significant changes occurred in the normal group.

Arthritis, Rheumatoid↗
PubMed1978

Night medication in rheumatoid arthritis. III. the use of sulindac.

A double-blind controlled trial was carried out in 18 in-patients with classical or definite rheumatoid arthritis to assess the effectiveness of night-time medication with 100 mg indomethacin plus 10 mg diazepam, 200 mg sulindac, and 200 mg sulindac plus 10 mg diazepam in improving sleep and reducing night pain and the duration of morning stiffness. Patients received each treatment regimen for 1 night. The results from the 17 patients completing the full trial protocol indicated that indomethacin plus diazepam was the most effective of the three regimens, although the differences did not reach conventional statistical significance. It is suggested that in further such studies with sulindac a larger dose and a longer duration of treatment should be used.

Arthritis, Rheumatoid↗
PubMed1977

Night medication in rheumatoid arthritis: II. Combined therapy with indomethacin and diazepam.

Seventeen of eighteen patients hospitalized for active rheumatoid arthritis completed a three-day randomized, double-blind comparison of 100 mg indomethacin, 100 mg indomethacin with 10 mg diazepam and matching placebo as night medication. The results showed a consistent pattern in the four functions measured--pain, morning stiffness, sleep score and patient preference. In each, indomethacin proved superior to placebo and the combined therapy better than indomethacin alone. From this it has been concluded that the combination of indomethacin and diazepam should now be considered the treatment of choice for maximum control of night pain and morning stiffness in rheumatoid arthritis.

Arthritis, Rheumatoid↗
PubMed1976

Some studies of feprazone.

Feprazone, 200 mg t.d.s., was compared with indomethacin, 25 mg t.d.s. rising to 50 mg t.d.s., in an eight-week double-blind cross-over study in twenty-three patients with active rheumatoid arthritis. Both therapies proved equally efficacious and acceptable. Measurement of the plasma levels of the two drugs showed no consistent correlation between efficacy and plasma concentrations.

Adult↗
PubMed1976

The effects of antacids on enteric-coated salicylate preparations.

A volunteer study was undertaken in which the effect of the co-administration of therapeutic doses of aluminium hydroxide and magnesium trisilicate on the excretion of aspirin derived from enteric-coated preparations was studied. A significant alteration in the pattern of salicylate excretion was seen, but the mechanism of the interaction cannot be deduced from the present study. It was concluded that the interaction was of potential therapeutic importance, and further studies based on this pilot investigation have been initiated.

Adult↗