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Biomedical subjects

I Hawryłkiewicz

Publications and source records attributed to I Hawryłkiewicz.

At least 37 records · Page 2Linked to original sources

[Pulmonary arterial pressure and the effect of short term oxygen therapy on it in patients qualified for home oxygen treatment].

Forty patients with chronic bronchitis and emphysema qualified for domiciliary oxygen treatment according to widely accepted criteria were assessed. Only two patients had normal pulmonary artery pressure. Pulmonary arterial pressure correlated well with oxygen arterial partial pressure. It seems that pulmonary hemodynamic studies are not necessary in patient qualification for domiciliary oxygen therapy. Short oxygen therapy (30 min.) produced only a small decrease of pulmonary artery pressure from 31 +/- 10 to 29 +/- 8 mm Hg. Only in 7 patients was the fall greater than 5 mm Hg. Fall of pressure in pulmonary artery produced by oxygen correlated only with initial pulmonary artery pressure and rose proportionally with increase of pressure.

Adult↗

Pulmonary haemodynamics at rest and during exercise in patients with sarcoidosis.

Pulmonary haemodynamics at rest and during exercise was studied in 30 patients with histologically confirmed sarcoidosis. All subjects were divided into three groups according to the stage of the disease assessed by radiological image of pulmonary lesions. At rest, in stage I and II patients, the mean pulmonary pressure (PAP) was normal. In stage III patients, a slight pulmonary hypertension was found. During exercise, a rise in PAP in stage I and II subjects was within the normal limits for a given workload, although in individual stage II subjects a rise in PAP was abnormally high. In all stage III patients a rise in PAP was pathologically elevated.

Adult↗

Effects of almitrine and oxygen on ventilation and gas exchange in patients with chronic respiratory insufficiency.

Effects of a new respiratory stimulant almitrine on lung ventilation and gas exchange were studied in 15 patients suffering from chronic respiratory insufficiency. The variables examined were measured during 4 consecutive periods lasting 30 min each. During the first period initial data were collected. From the second period to the end of the investigation, oxygen, 1.5 1/min, was administered. During the third phase, almitrine was infused at a dose of 0.33 mg/kg. Administration of oxygen increased arterial oxygen tension without change in lung ventilation. Infusion of almitrine increased minute ventilation by 27%. The increase in VE was entirely due to increase in tidal volume. There was a significant rise in arterial oxygen tension and decrease in carbon dioxide tension. Hyperventilation and improvement in blood gases were still observed 30 min after the infusion was completed. It is suggested that almitrine increases minute ventilation in patients with respiratory failure receiving oxygen.

Adult↗

Effects of ouabain on pulmonary haemodynamics in patients with hypoxic pulmonary hypertension.

Differing opinions about the use of digitalis in patients with cor pulmonale have led the authors to study haemodynamic effect of strophantin, a cardiotonic glycoside used as therapy of choice of decompensated cor pulmonale. Five patients with severe airways obstruction recovering from heart failure were studied. Ouabain at a dose of 0.01 mg/kg was infused into the pulmonary artery. Pulmonary artery pressure and flow were measured before, at the end of the infusion, 15 and 30 min after it. There was no change in the heart rate or mean pulmonary artery pressure and a slight increase in the pulmonary wedge pressure was observed after ouabain. The most important change concerned the pulmonary blood flow. The cardiac index rose from the initial 2.48 +/- 0.44 l/min/m2 to 3.67 +/- 1.3 l/min/m2 15 min after ouabain. The increase in cardiac output was entirely due to the increase in the stroke volume. Pulmonary vascular resistance fell from 502 +/- 208 dyn. s. cm-5 to 315 +/- 216 dyn. s. cm-5 15 min after ouabain. The findings support clinical preference for strophantin in patients with decompensated cor pulmonale.

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