Biomedical subjects

I Hemo

Publications and source records attributed to I Hemo.

29 records · Page 2Linked to original sources

PubMed1992

Microsurgery of the retina with a needle-guided 193-nm excimer laser.

This article presents a method used to guide the beam from an argon fluoride excimer laser to make it suitable for microsurgical purposes and confine it to areas that can be varied in dimension from 1 micron to tens or hundreds of microns. This approach guides the excimer laser beam with an articulated mechanical arm and confines it with variable-diameter tapered tubes, possibly allowing the use of this laser in in vitro retinal surgery with endolaser techniques. Currently, because of the lack of a delivery and focusing system for the 193-nm argon fluoride beam and its absorption by biologic liquids, this laser is used exclusively in ophthalmology for topical applications, such as corneal sculpting. This new method resolves these problems in a unique way with impressive results. Specifically, it was shown that, with this needle-guided excimer laser, it is possible to remove retinal tissue accurately without detectable damage to surrounding cells. Applications of this new technique in retinal surgery are discussed.

Animals↗

PubMed1990

In vivo angiogenic activity of interleukins.

Interleukin 1 incorporated into Elvax-40 (ethylene-vinyl-acetate copolymer consisting of 40% vinyl-acetate by weight) induces a rapid and strong angiogenic stimulus when implanted in rabbit corneas at a distance of 2.5 mm from the limbus. A constant and reproducible neovascular stimulus was observed with 5 ng per implant of recombinant human interleukin 1 alpha or 100 ng per implant of recombinant human interleukin 1 beta. At these concentrations, neither tumor necrosis factor nor interleukin 2 induced any neovascular stimulus. These data are interpreted as an indication for the possible role of interleukin 1 in angiogenesis of ocular (and other) tissues. As interleukin 1 is produced by various cells, it is hypothesized that this molecule may be the "unitarian angiogenic factor."

Animals↗

PubMed1989

Uveal lymphoid infiltrates: immunohistochemical evidence for a lymphoid neoplasia.

A 67-year-old man presented with a diffuse choroidal and ciliary body infiltrate, suggesting clinically and ultrasonographically a diffuse uveal melanoma. After enucleation both morphological and immunohistochemical data were highly suggestive of a diffuse, low-grade B cell lymphoma or lymphoplasmacytic immunocytoma. The difficulties of clinical and histopathological differential diagnosis of uveal lymphoid infiltrates are emphasised. In view of the excellent life prognosis of these tumours, treatment of the patient should be directed towards the preservation of ocular function.

Aged↗

PubMed1989

Fusarium oxysporum keratitis.

We describe herein a patient with a rare occurrence of mycotic keratitis caused by Fusarium oxysporum. The fungus destroyed the cornea, and a perforating corneal graft had to be performed. The drug of choice in such diagnosed cases is natamycin. A comparison between Fusarium oxysporum and Fusarium solani is discussed.

Adult↗

PubMed1988

Use of fibrin glue in ocular surgery.

Cryoprecipitate and thrombin were used to prevent bleeding and induce permanent conjunctival attachment in ten cases of retinal detachment, 40 cases of extracapsular cataract extraction, and ten cases of strabismus. This method proved to be a good alternative to suturing the conjunctiva in each of the above-mentioned surgical procedures, and appears to result in a better and more comfortable postoperative course.

Adhesives↗

PubMed1987

Promoting effect of n-decylmethyl sulfoxide on the penetrability of the optic nerve for lidocaine HCl in cats.

We examined the effect of n-decylmethyl sulfoxide (n-decylMSO) on the resistance of the optic nerve sheath to the penetration of lidocaine hydrochloride. Three series of experiments were carried out in living cats, administering lidocaine with and without n-decylMSO. The visual evoked potential (VEP) and optic nerve response (ONR) were measured. The results obtained indicated that n-decylMSO increased the penetration of lidocaine. The presence of lidocaine (1%) and n-decylMSO (2.5%) decreased the ONR amplitude from 120 to 15 microV after a time lag of 105 min, and VEP decreased from 9.0 to 5.5 microV. This effect was preserved during the experiment. Histological examination showed only minimal changes in the optic nerve and the eye globe and its contents. Some infiltration of mononuclear cells was found around the optic nerve sheath.

Anesthetics, Local↗

PubMed1987

Intraocular lens implantation in an underdeveloped country.

The results of 152 intraocular lens implantations performed at Mbabane Government Hospital, Swaziland, Africa, on 114 African patients with senile cataracts are presented. Surgery was performed with manual equipment and procedures. Lens implantation was accompanied by a low rate of postoperative complications. Uncorrected visual acuity of 20/120 or better was achieved in 79.6% of patients. The advantage of IOL implants over low-cost aphakic spectacles in Third World countries is discussed.

Aged↗

PubMed1987

Heterogenous expression of antigenic markers on retinoblasts.

Using a large panel of monoclonal antibodies to antigenic determinants specific for photoreceptor outer segments (S-Ag), for cells of neural (Leu-7) bipolar and/or ganglion cell (A2B5), glial/astrocytic (LN-1) or Muller's cell (M.M.) and two polyclonal antibodies to S-Ag and S-100 protein, the authors studied the expression of these antigenic determinants in four newly established retinoblastoma cell cultures and in cells derived from the Y-79 cell line. All four newly established retinoblastoma cell cultures demonstrated antigenic determinants specific for photoreceptors, astrocyte/glial and Muller's cells. The population of cells derived from the Y-79 cell line reacted mainly with the polyclonal antibody to S-100 protein, reflecting the homogeneity of its cell population mainly harboring antigenic determinants specific for astrocyte/glial cells. The heterogeneic staining of the newly established retinoblastoma cell cultures may reflect the multipotential-embryonic origin of these cells demonstrated by their ability to express antigenic determinants specific for the different cellular elements of the mature neuro-retina while the strictly glial staining of the Y-79 may be the result of cloning of this cell line.

Astrocytes↗

PubMed1987

Cryptophthalmos syndrome. Clinical and histopathological findings.

The clinical and histological findings in two cases of complete bilateral cryptophthalmos from two families are described. In one family, the genetic mode of transmission is most probably autosomal recessive. The parents were first cousins and from the ten deliveries only two children were alive. Seven offspring died soon after birth. At least two of these had complete bilateral cryptophthalmic features in addition to the described offspring. In the other family, the mode of transmission is unclear as the offspring was the first born of non-consanguineous parents with negative family history. Both cases showed similar external clinical appearance and anomalies. Chromosomal studies revealed normal female (first case) and male (second case) karyotypes. The latter, who died a few minutes after delivery, had bilateral agenesis demonstrating features compatible with Potter's syndrome. Apart from the complete covering of the eye globes with skin, the lack of eyebrows and eyelids, the two patients showed also similar histological ocular findings. The eyes in both cases demonstrated well developed posterior segment architecture including optic nerves, with a complete early arrest of anterior segment development and differentiation.

Abnormalities, Multiple↗

PubMed1985

Disappearance of keratic precipitates after intraocular surgery.

Two patients presenting with signs of anterior uveitis and keratic precipitates underwent intraocular surgery. When the bandages were changed, one day after surgery, it was observed that all the keratic precipitates had disappeared. The KPs did not reappear, and the eyes remained free of inflammation in the anterior segment during a six-month follow-up.

Adult↗

PubMedDate not supplied

The use of a silicone strip over the sclerotomy in vitreous surgery.

We have developed a technique to prevent enlargement and distortion of the sclerotomy wound during vitreoretinal surgery. The technique involves the use of a silicone strip temporarily attached to the sclera. The strip and the sclera are pierced with a lance-tipped blade and surgery is done by entering through the silicone strip and then through the resulting scleral opening. Such a procedure prevents undesirable enlargement of the sclerotomy induced by trauma to the wound caused by instruments that can occur in cases of previously damaged sclera or in thin sclera associated with high myopia. It also prevents leaks through the wound as instruments are withdrawn.

Humans↗