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Biomedical subjects

I Herrmann

Publications and source records attributed to I Herrmann.

35 records · Page 2Linked to original sources
PubMed1982

[Production and characterization of antisera against O,O-diethyl-O-(p-nitrophenyl)-phosphate (paraoxon)].

Methods for the production of antibodies against Paraoxon in rabbits are described. The highest-titre antisera were produced with conjugates containing a succinyl spacer group with a degree of derivatisation between 8 and 12 haptens per albumin molecule. The antibody response was tested by immunoprecipitation in agar gel with a hapten-rabbit-albumin-complex and by a radioimmunoassay. The synthesis of 125I labelled tracers is reported. The most potent antisera bound 50% of the radioactive tracer after 1:10(5) dilution and showed apparent affinity constants of 10(6) to 10(7) M-1 for Paraoxon. Compared to Paraoxon these antisera possessed cross reactivities with Parathion of 8.8 to 13.8%, with Methylparathion of 0.35 to 0.82%, and with Dimethoat of 0.0006 to 0.0012%.

Animals↗
PubMed1979

Beta-adrenoceptor blockade by atenolol, metoprolol and propranolol in the anaesthetized cat.

The inhibitory effects of atenolol, metoprolol and propranolol on isoprenaline-induced tachycardia, broncho-relaxation and vasodilatation were investigated in the reserpinized and anaesthetized cat. In low doses all three antagonists inhibited the heart rate response to isoprenaline, the order of potency being propranolol greater than metoprolol greater than atenolol. While propranolol inhibited the bronchodilation and vasodilation responses to isoprenaline in the same dose range as it blocked the heart rate response, atenolol and metoprolol had to be given in considerably higher doses to block these effects. The results indicate that both metoprolol and atenolol, in contrast to propranolol, are selective beta1-adrenoceptor antagonist. No statistically significant difference in the degree of selectivity was found between metoprolol and atenolol. The three compounds were devoid of intrinsic beta-mimetic activity.

Adrenergic beta-Antagonists↗
PubMed1977

In vivo labeling of platelets with 75Se -- selenomethionine in patients with hepatic cirrhosis and thrombocytopenia.

Labeling of platelets in vivo by 75Se -- Selenomethionine (75Se-M) was performed in nine cases of hepatic cirrhosis and thrombocytopenia for evaluation of the kinetics of platelet maturation. Folic acid and vitamin B12 deficiency was excluded by pretreatment of the patients with these agents. The platelet maturation time -- time between the injection of the isotope and maximum radioactivity of separated blood platelets -- was shortened to 7.7 +/- 1.1 days (mean +/- SD) compared to the normal 9.1 +/- 1.4 days. For explanation a disturbance of megakaryocyte maturation and/or platelet release from the bone marrow is suggested.

Adult↗
PubMed1975

Cleavage of cardiac steroid glucosides by pure beta-glucosidase from Aspergillus ventii.

Electrophoretically pure beta-glucosidase (beta-glucoside glucohydrolase, EC 3.2.1.21) A3 from Aspergillus wentii was shown to deglucosylate cardiac steroid biosides, triosides and tetraosides with a terminal beta-D-glucoside residue linked to the aglycon sugar in 1 leads to 6 or 1 leads to 4 position. In dependence on the structure and conformation of the aglycon, the deglucosylation rate may vary by six orders of magnitude.

Aspergillus↗
PubMedDate not supplied

Impact of implant interdependency when evaluating success rates: a statistical analysis of multicenter results.

PURPOSE: When evaluating the outcome of oral implant treatment, a statistically important aspect to consider is whether any dependency exists among implants placed within the same patient/jaw. If one implant fails, will the risk of subsequent failures increase, i.e., will any of the remaining implants also fail? In an attempt to study this question, the aims of the present study were to statistically determine if the suggested hypothesis was valid, i.e., whether dependency exists among implants in the same patient/jaw, and to determine how failure lifetable analysis should be calculated. MATERIALS AND METHODS: In the present study, multicenter trial material consisting of 1.738 oral implants in 487 patients from 4 separate studies was used. First, any dependency among implants within the same patient/jaw was determined; thereafter, cumulative success rates were calculated for one implant per patient (chosen randomly), and the range of variations in the randomized success rates was also calculated. This was then compared with the cumulative success rates based on the entire material. RESULTS: The statistical analysis showed that a dependency among the implants existed prior to their functional loading, i.e., the risk for an implant failure among the remaining implants in the same patient/jaw increased after the first failure had occurred. CONCLUSION: Both study design and statistical analysis are of importance when comparing success rates from various investigations, since dependency among implants in the same patient/jaw does exist and may influence the success rates. Consequently, it is suggested that only one randomly selected implant from each patient should be considered when calculating implant success rates.

Dental Implantation, Endosseous↗
PubMedDate not supplied

Clinical application of narrow Brånemark System implants for single-tooth restorations.

Replacing small, single incisors with implants can be esthetically challenging and difficult because of the limited amount of bone. In this investigation, 3.0-mm-diameter implants were used to support 30 single maxillary and mandibular incisors in 21 patients. The implants have been in function for 3 to 7 years, and 29 are still stable. Only 2 complications in the mandibular incisor region have occurred; 1 implant fractured (after 5 years of function) and 1 prosthesis was replaced. The overall success rate is 96.7%. The favorable results and esthetic appearance achieved suggest that replacing small incisors where light occlusal forces are present with narrower implants is a feasible treatment option.

Adolescent↗
PubMedDate not supplied

Osseointegrated implants for single-tooth replacement: progress report from a multicenter prospective study after 3 years.

After 3 years, 82 of the original 92 patients remain in this prospective multicenter study of single-tooth restorations supported by Brånemark implants. Since the 1-year follow-up, 6 more patients have been lost, but no additional implants have failed in those patients examined at the 3-year follow-up visit. After 1 year of function, 97.2% of the implants survived in 88 patients, and between the 1- and 3-year follow-up, 100% survived in 82 patients, giving a 3-year cumulative success rate of 97.2%. No changes were observed in the status of gingivitis, pocket depth, periodontal pocket bleeding index, and tooth and implant mobility from those reported after 1 year. Marginal bone resorption remained at a low level--less than 0.1 mm annually during the second and third years. Abutment screw loosening continued, but at a significantly reduced rate from that reported after 1 year. When used, gold rather than titanium abutment screws remained secure.

Adult↗
PubMedDate not supplied

A 5-year prospective multicenter follow-up report on overdentures supported by osseointegrated implants.

This report presents the results of a 5-year prospective multicenter study including nine centers worldwide. A total of 30 patients received 117 Brånemark implants in the maxillae, and 103 patients received 393 implants in the mandibles. According to the protocol, all integrated maxillary implants were to be loaded; however, only two of four mandibular implants were planned for support of the overdentures, leaving the remaining implants covered by mucosa as backup for possible implant failures. Thirty-five patients (26.3%) who were provided with 127 implants (24.9%) were withdrawn from the study. Six patients treated in the maxilla lost all their implants and resumed wearing complete dentures. The cumulative success rates for implants and for overdentures supported by two implants in the edentulous mandible were 94.5% and 100%, respectively. The corresponding cumulative success rates for implants and for overdentures supported by an optimal number of implants in the maxilla were 72.4% and 77.9%, respectively. Significantly better jawbone characteristics at the time of implant surgery were considered to contribute to the better cumulative success rates in the mandibles. Mean marginal bone loss was 0.8 mm (SD 0.8) and 0.5 mm (SD 0.8) for loaded implants during a 5-year period of time in the maxillae and mandibles, respectively. Measurements of the clinical height of the abutment cylinders indicated a mean recession (0.2 mm) of peri-implant mucosa during the follow-up period in the mandibles. Conversely, hyperplasia was observed in the maxillae.

Adult↗
PubMedDate not supplied

Osseointegrated implants for single-tooth replacement: a prospective 5-year multicenter study.

One hundred seven Brånemark implants were placed in 92 patients participating in an international multicenter trial on single-implant restorations at seven centers. The patients were followed for 5 years in a prospective study focusing on implant success and crown function. Plaque and gingival indexes, as well as probing depths, were recorded around teeth and implants. The marginal bone level at implants was determined from intraoral radiographs. Only three implants (2.8%) had been lost at the final annual checkup. During the follow-up period, a total of 17 patients dropped out or were excluded because of nonconformity with the protocol. Based on the remaining patients, a total of 86 implants were clinically and radiographically evaluated at the 5-year follow-up period, resulting in a cumulative success rate of 96.6% (71 implants) in the maxillae and 100% (15 implants) in the mandibles. Plaque and gingival indexes showed a similar pattern of good health around both natural teeth and titanium abutments. The marginal bone loss during the 5-year period did not exceed 1 mm as a mean for all implants analyzed. The most frequent complication recorded during the follow-up was loosening of the abutment fixation screw. The outcome of this study indicated that safe and highly predictable results can be obtained for 5 years when Brånemark implants are used to support single-tooth restorations.

Alveolar Bone Loss↗