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Biomedical subjects

I Hewitt

Publications and source records attributed to I Hewitt.

6 recordsLinked to original sources
PubMed1997

Indices of renal tubular function in perinatal asphyxia.

AIMS: To determine and compare two urinary indices of renal tubular function, N-acetyl-glucosaminidase (NAG) and beta 2-microglobulin (beta 2 M), in healthy term neonates and babies with perinatal asphyxia. METHODS: In a prospective case-control study using asphyxiated (n = 35) and normal control (n = 55) infants, urinary NAG and beta 2 M were assayed at 24-48 hours of life, 4-6 days, and 4-6 weeks. RESULTS: NAG and beta 2 M were significantly increased at 24-48 hours and 4-6 days in the asphyxiated infants compared with the controls. Increased NAG values reflect the degree of perinatal asphyxia more than do beta 2 M. Gentamicin also increased NAG excretion, but to a lesser extent than did perinatal asphyxia. CONCLUSIONS: NAG (+/- beta 2 M) may be a useful marker of perinatal asphyxia. Urinary NAG concentrations correlate with the severity of perinatal asphyxia.

Acetylglucosaminidase↗
PubMed1991

Ureteric sludge syndrome.

Four cases of a form of obstructive uropathy previously unreported in children are described. All presented with oligoanuria and either flank pain or fluid retention and had evidence of crystalline sludge in their lower ureters. Three cases had an underlying crystalluria.

Adolescent↗
PubMedDate not supplied

The loneliness of the long-distance manager.

Many top managers have been tempted to neglect their own development in the face of massive work agendas. The experiences of 12 senior NHS managers, who were involved in a project designed and implemented by the NHS Training Directorate (NHSTD), bear this out, as Margaret Attwood and colleagues discuss.

Administrative Personnel↗