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Biomedical subjects

I Hod

Publications and source records attributed to I Hod.

At least 37 records · Page 2Linked to original sources
PubMed1986

Rejection of deeply implanted foreign body induced by acupuncture treatment in patient suffering intractable pains lasting ten years following traumatic injury to the left scapular region during a road accident.

Upper back pains lasting ten years were promptly improved in a 63 year old woman following the rejection of a forgotten foreign glass body, through a scar located over the left scapula, and treated by acupuncture. The patient insisted on having this treatment after unsuccessful prolonged and multi-disciplinary formal medical interventions culminating in preparations for exploratory surgery. The acupuncture directed to the scar induced an inflammatory reaction characterized by a sterile granulomatous reaction which surrounded a large piece of glass, apparently implanted in the soft tissue of the suprascapular area during a severe road accident which occurred ten years previously. The surgical intervention was avoided.

Acupuncture Therapy↗
PubMed1986

Tension headache treated by anti-inflammatory drug injected into GB 20 acupuncture point.

The anti-inflammatory drug Voltaren (0-(36-dichlorophenyl)-amino acetate) is a relatively new substance in the systemic treatment of various pain inducing diseases related to the musculoskeletal elements. In order to achieve effective results, relatively high dosage, applied P.O.P.R. or I.M. should be used for prolonged periods. The acupuncture methods presented the eastern minded western physician with a detailed list of trigger points which may have abrogated certain painful symptoms when appropriately used by acupuncture maneuvers alone. In the present study the possibility of using the appropriate acupuncture point GB 20 for the injection of Voltaren, in an attempt to relieve stable and prolonged tension headaches, has been considered. Thus, acceptable and combined eastern-western treatment method, if found successful, may be evolved. GB 20 point has been selected because of its effective influence among others, on tension headaches, a highly common and most distressing syndrome poorly treated by conventional approaches in most clinics.

Acupuncture Therapy↗
PubMed1985

The contribution of thermo-moxibustion to surgical treatment in transplanted mouse mammary carcinoma.

BALB/C mice bearing progressive transplanted mammary carcinoma were treated by surgical removal of the tumor mass either with or without thermo-moxibustion, applied to the GV 14-point-equivalent. A surgical removal of the tumor, 14 days post-inoculation resulted in 61% of deaths compared with 90.0% of deaths in the sham operated control. By the addition of the thermo-moxibustion therapy, the mortality rate, in the surgically treated group was reduced to 37.5%. Surgical removal of the tumor mass at day 17 post-inoculation resulted in 70% death while surgery supported by thermo-moxibustion protected the animals to the range of 40% death. Surgical removal of the tumor mass followed by local heterologous immuno-therapy was very effective when applied 14 days post-inoculation (12.5% death only). However, the same procedures applied at day 17 post-inoculation were not effective (80% death). Surgery and moxibustion together were more effective than surgery alone. Surgery and immunotherapy were very effective when applied from day 14 post-inoculation. Thermo-moxibustion as the sole treatment was effective when applied either before or very close to the tumor cell inoculation (35% of death and 33% of death respectively, as compared to 61.7% death in the control). Thermo-moxibustion applied before and after tumor cell inoculation was more effective (15% death rate). Thermo-moxibustion either alone or in conjunction with surgery is a contribution to the protection of BALB/C mice against the early and the late development of mouse mammary carcinoma.

Animals↗
PubMed1984

Isolation and characterization of a novel retrovirus from sheep affected by pulmonary carcinoma.

Sheep pulmonary carcinoma (SPC) has been shown to be associated in nature with a retrovirus, by electron microscopic, biochemical, and epidemiological criteria and by experimental transmission. In this study, a retrovirus has been isolated from SPC tumors which were experimentally induced by inoculation with a cell-free, reverse transcriptase containing fraction from a spontaneous field case of SPC, and propagated in culture. This novel virus was shown to be unrelated to murine, avian, and bovine leukemia viruses, to be exogenous to the ovine species, and to have only limited genetic relatedness to the lentiviridae (maedi-visna and caprine arthritis encephalitis virus).

Animals↗
PubMed1984

Osmotic fragility of rat embryo red blood cells collected during intrauterine growth.

Whole blood was tapped from the embryos of anaesthetized pregnant New Zealand rats using a micropipette of approximately 250 microm diameter, inserted through the uterine wall via a 5-mm incision in the anterior abdominal wall. The procedure was repeated 3 times (days 15, 17 and 19 of fetal life) in the same pregnant rats, and thereafter, twice in the surviving newborns (days 14 and 30 of neonatal life). Osmotic fragility of the red blood cells (RBC), reticulocyte counts and haemoglobin values of each sample were analysed. The fragility curve of the fetuses showed the presence of 2 types of cell population: a fragile and a more resistant type. This was correlated with the number of immature RBC (reticulocytes) in the samples. Starch gel electrophoresis of the haemoglobin revealed 4 fractions in both the fetuses and newborn animals.

Animals↗
PubMed1984

Heterotransplantation of experimentally induced sheep lung adenomatosis into nude mice.

Male ICR nude mice inoculated subcutaneously with minced tissue obtained from pulmonary adenomatosis of sheep which was induced by RNA type-C retrovirus developed a transplant which contained cysts lined by a proliferative epithelium. These cysts showed several characteristics of the epithelial tumour cells of origin, such as high glycogen content and secretion of mucin. Microinvasion of epithelial cells from the adenomatous cysts into the stroma was observed. The stromal tissue demonstrated islets of cartilage. It was concluded that virus-induced pulmonary carcinoma of sheep can be transplanted and grown in nude mice.

Animals↗
PubMed1983

Normal tissue response to localized deep microwave hyperthermia in the rabbit's prostate: a preclinical study.

Experiments were performed to determine the response of normal tissues of the rectal cavity and the prostate to localized 2.45 GHz microwave deep hyperthermia. Hyperthermia at 43 degrees C was delivered by means of a coaxial probe in the rectal cavity for 30 min. once or twice at an interval of 2 days. Normal tissues of the rectum, urinary bladder, and prostate were histologically examined up to three months after treatments. In almost all of the treated animals no tissue and organ injury resulted from localized deep hyperthermia at 43 degrees C. This treatment appears to be safe for the treatment of carcinoma of the prostate.

Animals↗
PubMed1979

Lung carcinoma of sheep (jaagsiekte): tissue-bound precipitating antibodies.

Firmly bound IgG was examined and its activity was tested in spontaneous lung carcinoma of sheep (jaagsiekte). High levels of IgG were extracted by acid-glycine buffer (GB) at pH 2.8 from both the tumor tissue and normal lung, which were exhaustively prewashed by phosphate-buffered saline (PBS) at pH 7.4. The first acid-GB eluates of the normal or tumor tissue acted in the immunodiffusion test as precipitating antibodies against antigens of the first PBS eluate of the tumor tissue. In addition, free intracytoplasmic type A particles were observed in cell-free tumor extract.

Animals↗
PubMed1977

Differences in production of solid Landhscütz tumours in BALB/c and ICR mice.

Landschütz tumour cells in the ascitic form injected subcutaneously into BALB/c or ICR mice produce solid tumours which grow progressively in most ICR mice but regress in nearly all BALB/c mice. Solid tumours in the peritoneal wall (produced by intraperitoneal inoculation of ascitic cells and treatment with normal serum) grew in both strains, but were more invasive in ICR mice. Surgical interference in BALB/c mice with these tumours, allowing adhesion of tumour to skin or subcutaneous fascia, resulted in cessation of tumour growth or regression.

Animals↗
PubMed1977

Pulmonary carcinoma (Jaagsiekte) of sheep. Ultrastructural study of early and advanced tumor lesions.

Lung carcinoma of sheep (Jaagsiekte) is a bronchiolar-alveolar cell carcinoma. Differences in the ultrastructural patterns of early and advanced lesions of the disease are described. A-type and C-type viruses were observed in advanced tumors and were absent in early lesions. Numerous microtubules were characteristic in the epithelial tumor cells of the early lesions and were absent in the advanced tumor. In comparison to the early lesions, extensive cytosome production, surfactant secretion, and glycogen accumulation were observed in the advanced tumor. The immune response to the early tumor lesion was restricted to the peribronchiolar lymph aggregates, while in the advanced stages of the disease the systemic immune response was markedly increased.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1975

Solid intraperitoneal Landschütz tumour in mice: implications in cancer chemotherapy and immunology studies.

Multiple intraperitoneal injections of various normal sera into BALB/c mice inoculated intraperitoneally with Landschütz ascites tumour cells abrogated the development of ascitic syndrome in almost all the animals. In a large proportion of the survivors solid intraperitoneal tumours developed, composed of characteristic ascites tumour cells engulfed and encapsulated in connective tissue. The effect of serum on the development of the solid tumour was diminished if the donor had been immunized against mouse IgG. Inoculated animals treated with serum hyperimmune against mouse IgG showed accelerated ascitic tumour growth. Cyclophosphamide or arabinosylcytosine strongly inhibited growth of solid tumours. Simultaneous administration of arabinosylcytosine and its antagonist cycloheximide did not interrupt tumour growth.

Animals↗