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Biomedical subjects

I Holló

Publications and source records attributed to I Holló.

At least 37 records · Page 2Linked to original sources
PubMed1983

Effects of prolonged aminoglutethimid and dehydroepiandrosterone treatment on rat bones.

Authors studied the effect of prolonged sex hormone deficiency on some parameters of bone metabolism in calcitonin sensitive young male rats. 30 rats were given aminoglutethimid (AG) for 36 days. Part of these animals received plus dehydroepiandrosterone (DEA) treatment. Corticoid deficiency was substituted by cortisone. In addition 22 rats were administered only cortisone, 11 animals cortisone and DEA, and 10 rats only DEA for 36 days. On day 37 the different parameters of treated rats were compared to findings in 31 control animals. It has been found that body weight, calcitonin hypocalcaemia, serum alkaline phosphatase, as well as bone ash weight pro unit body weight was significantly lower in AG treated rats as compared to controls and rats receiving DEA in addition to AG. Values of latter group did not differ from controls. It has also been established that neither cortisone substitution nor isolated DEA treatment did involve significant differences in the studied parameters of bone metabolism as compared to controls. The findings support the opinion that sex hormone deficiency, directly or indirectly results osteoporosis. The experimental model seems to be suitable for the study of androgen deficient osteopenia.

Alkaline Phosphatase↗
PubMed1980

Sulpiride and thyrotrophin releasing hormone loading test in patients with acromegaly.

The effects of sulpiride, a dopamine receptor blocking agent, and of thyrotrophin-releasing hormone (TRH) were studied on prolactin secretion in 17 patients with acromegaly and 25 control subjects. THe basal serum prolactin level was increased in 9 acromegalic patients. After sulpiride loading, maximum changes in prolactin level were significantly smaller in acromegalic patients, irrespective of the basal prolactin concentration. TRH loading resulted in a decrease of prolactin secretion predominantly in the patients with high basal serum hormone levels. A blunted thyrotrophin response to TSH was found only in those acromegalic patients who had concomitant thyroid disease. Higher than normal basal prolactin levels in some of the acromegalic patients and abnormal prolactin responses following sulpiride and TRH loading in most of the patients with acromegaly are attributed to deranged hypothalamo-hypophyseal regulation.

Acromegaly↗