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Biomedical subjects

I Holland

Publications and source records attributed to I Holland.

10 recordsLinked to original sources
PubMed2001

CHOD/BVAM regimen plus radiotherapy in patients with primary CNS non-Hodgkin's lymphoma.

PURPOSE: To assess the efficacy and toxicity, including long-term neurotoxicity, of combined therapy with the CHOD/BVAM regimen given before cranial radiotherapy in the treatment of primary CNS lymphoma (PCNSL). METHODS AND MATERIALS: Thirty-one consecutive patients with PCNSL were treated with one cycle of cyclophosphamide, doxorubicin, vincristine, and dexamethasone (CHOD) and two of carmustine (BCNU), vincristine, cytosine arabinoside, and methotrexate (BVAM), followed by cranial radiotherapy (45 Gy whole brain plus a 10-Gy boost for single lesions). The median age was 59 years (range 21-70) and 39% had poor performance status. The median follow-up of patients was 4.1 years (range 2.7-9.0). RESULTS: Twenty-one patients had no PCNSL at the end of treatment. The 5-year actuarial probability of survival was 31% (95% confidence interval [CI]: 11%-57%), with a median survival of 38 months. Patients < 60 years had a survival significantly longer than those > or = 60 years (4-year survival: 58% (95% CI: 34-82%) vs. 29% (95% CI: 5-53%), respectively; p = 0.04). Two patients died during chemotherapy from pulmonary embolism and bronchopneumonia, respectively, with no evidence of PCNSL at the autopsy. Dementia probably related to treatment occurred in 5 (62%) of the 8 patients 60 years and older, and 4 of them died without evidence of relapse of PCNSL. Dementia correlated with developing brain atrophy and leuco-encephalopathy on serial CT or MR scans. CONCLUSION: This regimen can be given with the planned dose intensity to patients aged less than 70 years, and produces better survival than that reported with radiotherapy alone; however, dementia occurs in the majority of patients aged 60 years of age or more.

Adult↗
PubMed2000

Airsickness and aircraft motion during short-haul flights.

BACKGROUND: There is little quantitative information that can be used to predict the incidence of airsickness from the motions experienced in military or civil aviation. This study examines the relationship between low-frequency aircraft motion and passenger sickness in short-haul turboprop flights within the United Kingdom. METHODS: A questionnaire survey of 923 fare-paying passengers was conducted on 38 commercial airline flights. Concurrent measurements of aircraft motion were made on all journeys, yielding approximately 30 h of aircraft motion data. RESULTS: Overall, 0.5% of passengers reported vomiting, 8.4% reported nausea (range 0% to 34.8%) and 16.2% reported illness (range 0% to 47.8%) during flight. Positive correlations were found between the percentage of passengers who experienced nausea or felt ill and the magnitude of low-frequency lateral and vertical motion, although neither motion uniquely predicted airsickness. The incidence of motion sickness also varied with passenger age, gender, food consumption and activity during air travel. No differences in sickness were found between passengers located in different seating sections of the aircraft, or as a function of moderate levels of alcohol consumption. CONCLUSIONS: The passenger responses suggest that a useful prediction of airsickness can be obtained from magnitudes of low frequency aircraft motion. However, some variations in airsickness may also be explained by individual differences between passengers and their psychological perception of flying.

Acceleration↗
PubMed1997

A study of the CT findings in 100 patients with rhinosinusitis and 100 controls.

One hundred computerized tomography (CT) scans from patients with rhinosinusitis were compared with 100 CT scans from patients with intraorbital disease. There were no significant bony anatomical differences between the rhinosinusitis group and the control group and there remained no difference when 17% of the control group, who were incidentally found to have mucosal changes, were excluded from the control data. None of the anatomical bony variations compared between the two groups showed any significant difference, including any associated with narrowing of the ostiomeatal complex (P = 0.41). Eight per cent of all subjects (n = 200) had Onodi cells and 7% had an asymmetrical anterior skull base. In conclusion, bony anatomical variations appear not to influence the prevalence of rhinosinusitis. Intrinsic mucosal disease is probably of much more importance than the bony anatomy.

Adult↗
PubMed1996

Comparison of magnetic resonance angiography with conventional angiography in the detection of intracranial aneurysms in patients presenting with subarachnoid haemorrhage.

Thirty-nine patients admitted with proven subarachnoid haemorrhage were imaged both with 3-D time of flight (TOF) magnetic resonance angiography (MRA) and conventional angiography. As the definitive examination, catheter angiography demonstrated 37 aneurysms; ten patients had no aneurysm, the remaining 29 patients had 37 aneurysms. We found the sensitivity of 3-D TOF MRA for the detection of aneurysms to be 81% and specificity to be 100% when the reporting radiologist inspects not only the MIP reconstructions but also the MRA source data and the axial spin-echo images. The investigation is less accurate if all the available imaging data is not considered.

Adult↗
PubMed1991

Primary non-Hodgkin's lymphoma of the central nervous system: phase II study of chemotherapy (BVAM) prior to radiotherapy.

Ten patients were diagnosed as having primary non-Hodgkin's lymphoma of the central nervous system at University Hospital, Nottingham, between September 1986 and April 1989. None had clinical evidence of HIV-1 infection. All the patients started treatment with chemotherapy (BVAM), designed to cross the blood-brain barrier, followed by radiotherapy. Seven patients completed both chemotherapy and radiotherapy. Dose reduction during chemotherapy was necessary in three patients because of neutropenia. In two of the six patients with solitary tumours, complete resection was achieved surgically prior to treatment. Five of the remaining eight patients (63%) had radiological evidence of a complete response with chemotherapy. The other three patients had no response to chemotherapy but one had a complete response after radiotherapy. The two-year cause-specific survival of the 10 patients was 37%. Two of the three patients who had a postoperative performance status of 0 or 1 (ECOG/WHO) are alive and disease-free at 26 and 46 months from diagnosis. The median survival of the seven patients with a performance status of 2-4 was 10 months with two patients alive and disease-free at 19 and 26 months. The two-year cause-specific survival of these seven patients was 22%.

Adult↗
PubMed1990

Alveolar ridge augmentation using a new design of inflatable tissue expander: surgical technique and preliminary results.

Ridge augmentation with particulate hydroxyapatite (HA) is compromised by the propensity for the HA particles to disseminate throughout any surgically created space within the tissues. Several techniques designed to overcome this problem have been described, including the use of inflatable tissue expanders. Some of the residual problems related to this technique are attributable to aspects of expander design and surgical technique. This paper which describes a new design of tissue expander which is completely submerged in use, also describes in detail the surgical technique associated with it. Preliminary results are discussed.

Alveolar Process↗
PubMed1989

Haemangiopericytoma of the larynx.

Haemangiopericytoma is an uncommon vascular tumour which has rarely been recorded in the larynx. The diagnostic and histopathological difficulties are discussed. A total laryngectomy was performed because of the size and site of the tumour, the associated risk of local recurrence and the high metastatic rate.

Aged↗
PubMed1981

Benign communicating hydrocephalus in children.

A review was performed of the computed tomograms (CTs) of 500 children which had been reported as showing widening of the supratentorial subarachnoid spaces with normal cerebral substance. On the basis of this a radiological diagnosis of cerebral atrophy had been made in all but five, who were said to have megalencephaly. From these, the children with large or abnormally enlarging heads, but normal or only slightly enlarged ventricles, were selected; there were 40 such cases (8%). The clinical condition either improved or remained stable over a period of 2 years; in the majority the scan abnormality regressed (22.5%) or remained static (67.5%). In three cases there was slight progression of the CT changes before stabilisation, but only one case developed classical communicating hydrocephalus necessitating a shunt procedure. This condition is a generally benign and mild form of communicating hydrocephalus, for which an aetiological factor was apparent in about two-thirds of the cases studied.

Child, Preschool↗
PubMed1979

Pneumatosis coli in adult acute myeloid leukaemia.

Three cases of pneumatosis coli (PC) in adult patients with acute myeloid leukaemia seen over the last five years in Hammersmith Hospital are reported. Although definite conclusions are impossible, we suggest that that pneumatosis could be due to damage to the bowel mucosa as a result of the disease or the treatment. The literature is reviewed and discussed in an inconclusive attempt to discover the source of the gas.

Adolescent↗