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Biomedical subjects

I Holten

Publications and source records attributed to I Holten.

At least 19 recordsLinked to original sources
PubMed1998

Evidence for immune system involvement in reflex sympathetic dystrophy.

Skin biopsies from patients with reflex sympathetic dystrophy were immunostained using a variety of antisera. An incidental finding with S100 staining was the presence of numerous Langerhans cells in the epidermis. All patients had significant pain at the time of biopsy, and all had symptoms refractory to treatment. The potential implications of this finding are discussed.

Adult↗
PubMed1996

The ultrasonic diagnosis of urachal anomalies.

Seven cases of urachal anomalies are presented. The spectrum of the disorder and the criteria for ultrasound diagnosis are described. Six of seven cases were correctly diagnosed pre-operatively with diagnostic ultrasound, but one case with no cystic component was missed. The appearance of a fixed, midline, cystic, extraperitoneal swelling between the umbilicus and the bladder should suggest the diagnosis.

Adolescent↗
PubMed1992

Dieulafoy's ulcer: a palpable entity?

Two cases of Dieulafoy's ulcer are reported. Diagnosis was delayed but successful surgical treatment was achieved once the lesion was located by palpation.

Adult↗
PubMed1990

Parathyroid cyst: report of case in the mediastinum.

Though a rare lesion a parathyroid cyst is of clinical significance because it usually mimics a thyroid cyst and can be associated with hyperparathyroidism. The cyst can be ectopic with location in the lateral neck or in the mediastinum and therefore constitutes a differential diagnosis to a branchial or thymic cyst. A case report of a mediastinal parathyroid cyst without hyperparathyroidism is presented. Fine needle aspiration with parathyroid hormone assay on the cyst fluid will reveal the correct diagnosis. Surgical removal of the cyst is recommended, and hyperparathyroidism should be considered.

Adult↗
PubMed1989

Malignant fibrous histiocytoma of the kidney.

Malignant fibrous histiocytoma is a primitive mesenchymal tumor which seldom occurs in the genitourinary organs. Despite radical operation, prognosis is generally poor and seems not to be improved by chemotherapy or radiotherapy. We present a case of a malignant fibrous histiocytoma of the renal capsule. The tumor could be removed totally and no signs of metastases were found. Eight months later the patient was readmitted with recurrence of tumor and widespread metastases.

Adult↗
PubMed1988

Early changes in parathyroid function after high-dose irradiation of the neck.

Hyperparathyroidism (HPT) will develop years later in a number of patients irradiated to the neck for benign diseases. Twenty-nine patients with malignant diseases were studied for 3 years after irradiation with cancer therapeutic doses to the neck. The serum concentration of parathyroid hormone (iPTH) showed an increasing trend suggesting that HPT also might develop in these patients.

Calcium↗
PubMed1988

Interleukin-1 affects the function of cultured human thyroid cells.

Cytokines are peptide hormones essential for cellular communication in the immune response. The purpose of this study was to investigate the influence of cytokines, especially recombinant interleukin 1 beta (rIL-1 beta), on human thyroid cells. Thyroglobulin (Tg) was measured by a double antibody radioimmunoassay, and cyclic AMP (cAMP) by a competitive protein binding assay. Supernatants from unstimulated and phytohaemagglutinin-stimulated blood mononuclear cells were added to human thyroid cells cultured in monolayers. A dose-dependent inhibition of the secretion of Tg and cAMP was demonstrated. Both subcultured and primary cultured cells incubated with rIL-1 beta at pharmacological levels (10(-1)-10(2) U/ml) exhibited an inhibition of Tg and cAMP secretion, while at physiological levels (10(-5)-10(-3) U/ml), the secretion of Tg was enhanced. The similar stimulation of cAMP was demonstrated in subcultures. These in vitro studies suggest that IL-1 beta may play a role in the pathogenesis of autoimmune thyroid diseases. Further, the stimulations at low concentrations indicate that IL-1 beta may regulate the function of the thyroid gland under physiological conditions.

Autoimmune Diseases↗
PubMed1984

Unchanged parathyroid function following irradiation for malignancies of the head and neck.

Irradiation to the neck increases the prevalence of hyperparathyroidism and may cause parathyroid insufficiency. In this study, 35 patients who received therapeutic irradiation to the neck and a control group comprising 19 patients who received radiation to the bladder were studied before, during, and until 2 months after irradiation in order to see whether there were any measurable changes in the parathyroid function. In both groups the serum concentrations of calcium, phosphate and parathyroid hormone were unchanged. Serum protein and albumin decreased in the bladder cancer group. The results support the concept that the parathyroid gland has a low radiation sensitivity, and radiation induced changes may not manifest itself before years after irradiation, due to the low mitotic activity.

Adult↗
PubMed1983

Influence of thyroid substitution therapy and thyroid autoantibodies on the value of serum thyroglobulin in recurring thyroid cancer.

The study was performed to evaluate the influence of thyroxine substitution therapy and the presence of thyroglobulin antibodies (TgAb) on the usefulness of serum thyroglobulin (Tg) measurements in the follow-up of patients treated for well differentiated thyroid carcinoma. Seventy-two consecutive patients with differentiated thyroid cancer and eight with medullary carcinoma as well as controls were studied on one or more occasions and blood was drawn for measurement of serum Tg, TgAb, TSH and thyroid hormones. In 23 patients the hormonal substitution was withdrawn and 3-4 weeks later new blood samples and a 131I scintigraphy was performed. Eighteen patients were shown to have recurrence or metastases. Four of these had TgAb, two had normal Tg values, and the remaining 12 had extremely elevated levels. Those with TgAb and normal Tg values all had high Tg levels off thyroxine substitution. The 54 patients without evidence of recurrence had low levels of serum Tg except for one with highly elevated values. Based on the results from this and other studies is concluded that serum Tg is an important adjunct in the follow-up of patients with well differentiated thyroid carcinoma, but certain limiting factors have to be taken into account, i.e., the radicality of surgery, the sufficiency of the substitution, the presence of TgAb and the method for measurement of Tg.

Adolescent↗
PubMed1980

Nuclear imaging of pulmonary metastases in thyroid carcinoma.

Pulmonary metastases were diagnosed in 14 of 52 patients with well differentiated thyroid carcinoma by 131I whole body scintigraphy or radiography. Three patients had metastases only demonstrable on scintigraphy, whereas chest radiography was diagnostic in 4 patients with normal scintigraphic findings. Thus, in this type of thyroid carcinoma, neither 131I scintigraphy nor routine chest films alone will reveal all cases of pulmonary metastases.

Adolescent↗