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Biomedical subjects

I Honda

Publications and source records attributed to I Honda.

At least 37 records · Page 2Linked to original sources

[Nursing situation in outpatient chemotherapy following surgery for gastric cancer].

At this Cancer Center, we have sought to improve gastric cancer patients' QOL and the bed use rate, by conducting chemotherapy following gastric cancer surgery since 1988. Initially, EAP therapy was performed, but numerous cases had to be hospitalized for complications, so outpatient treatment proved difficult. At present, we mainly employ CDDP-5-FU combination therapy or MTX-5-FU as an alternative. Up to 1995, 26 and 88 patients underwent each type (total, 114 cases). It is our policy to brief carefully both patients to receive the chemotherapy on an outpatient basis as well as their families beforehand. The orientation covers the administration methods, possible complications and measures to deal with them, and daily life situations to come. The idea is to encourage their understanding of the importance of self care, and obtain their cooperation in the therapy. We also try to measure for vital signs along with manage transfusions during administration, and endeavor to pinpoint complications in the early stage. We also have a 24-hour phone consultation service available so that both patient and family can continue home treatment without fear. This report concerns the situation with chemotherapy on an outpatient basis at our Center.

Adenocarcinoma↗

Metastable associative network models of dream sleep.

Up to the present day, simulations using a neural network model have been carried out under the global inhibition and the uncorrelated noise in order to simulate the dynamics transition of neuronal activities from the flat (slow wave sleep) to the 1/f (dream sleep) power spectral density profile during the sleep cycle in cats. In particular, the metastability of the network attractor is shown to be essential in generating the 1/f fluctuations. Here, the dynamics of neuronal and network activities are analyzed under the correlated noises mimicking a cholinergic drive. Regardless of the network structure, symmetry and asymmetry, the behavior of network activity and the escape time distributions show that the long-lasting autocorrelation of the noise prolongs its prescence in the metastable states. These results and the newly estimated network attractor show that the interplay between the metastability of the network attractor and the noise statistics determines the dynamics of network activity. Our results may be able to provide the novel framework to investigate the function of dreaming in the higher-order brain function.

Journal Article↗

Resection of liver metastasis from alpha-fetoprotein-producing early gastric cancer: report of a case.

We herein present a case of resected synchronous solitary liver metastasis from alpha-fetoprotein (AFP)-producing early gastric cancer. A 61-year-old woman, who was diagnosed at a routine medical checkup as having early gastric cancer with a liver tumor, came to our hospital for surgery. Her serum AFP level was high at 910 ng/ml. An examination was performed to determine whether the liver tumor was primary hepatocellular carcinoma or metastasis from early gastric cancer. She had no evidence of either a hepatitis B or C virus infection, and her liver function was normal. A biopsy specimen from the gastric cancer predominantly revealed moderately differentiated adenocarcinoma, but a focally trabecular pattern compatible with AFP-producing gastric cancer was also observed. Preoperatively, it was concluded that the liver tumor was metastasis from an AFP-producing early gastric cancer. We thus performed distal gastrectomy and a posterior segmentectomy of the liver. Her serum AFP level decreased to the normal range within 2 weeks after the operation. An immunohistological examination revealed that AFP-positive cells were present in both the gastric cancer and liver tumor. One year after the operation, there was no sign of recurrence.

Adenocarcinoma↗

Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction.

To determine the roles of endogenously released tachykinins (substance P [SP] and neurokinin A [NKA]) in the human bronchial tissues, we studied the effects of tachykinin antagonist FK224 on bronchial smooth muscle contraction induced by SP, NKA and capsaicin in an organ bath. FK224 (10(-6) M and 10(-5) M, respectively) significantly inhibited NKA-induced contraction and 10(-5) M FK224 shifted the dose-response curve to more than one log unit higher concentration. Because SP- and capsaicin-induced contractions were small, we pretreated the tissues with the neutral endopeptidase inhibitor phosphoramidon (10(-5) M), which inhibits degradation of exogenous tachykinins in order to potentiate the contractions. FK224 (10(-5) M) significantly inhibited SP-induced contraction and it shifted the dose-response curves to about one log unit higher concentration. FK224 (10(-5) M) also significantly inhibited capsaicin-induced contraction and it shifted the dose-response curves to more than one log unit higher concentration. In contrast, FK224 (10(-5) M) did not affect on acetylcholine-, histamine-, and leukotriene D4-induced contraction. These results suggest that FK224 is a tachykinin receptor antagonist in the human bronchial smooth muscle, and that capsaicin-induced contraction is due to endogenously released tachykinin-like substances in the human bronchus.

Acetylcholine↗

[Preoperative adjuvant chemotherapy with oral anticancer agents for stomach cancer].

We performed preoperative chemotherapy using oral anticancer agents and compared the survival rate with that of the untreated group. The statistical significance of effects in the oral anticancer agent groups was tested by multivariate analysis of the survival rate. The subjects were 488 patients who underwent resection of primary stomach cancer in the Chiba Cancer Center between 1981 and the end of 1991. Patients who were gross type 0 preoperatively, who died in the hospital or who had multiple or double cancer, were excluded. They were divided into two oral anticancer agent groups with 158 patients in the Tegafur group, 163 in the 5-FU group, and 167 patients in the untreated group. In addition to preoperative adjuvant chemotherapy, the age, gender, age, localization, gross type, depth of invasion, histological lymph node metastasis and the old histological stage were analyzed as explanatory variables. In both the Tegafur and 5-FU groups significant differences of p = 0.034 and p = 0.024 were obtained. Factors which had significant effects on survival rate were age (p < 0.0001), histological lymph node metastasis (p < 0.0001), age (p = 0.0001), depth of invasion (p = 0.002), and gross type 4 (p = 0.043). Therefore preoperative administration of oral anticancer agents appeared to have a significant effect on survival rates.

Administration, Oral↗

Ventral pancreatic resection for adenoma and low-grade malignancies of the head of the pancreas.

The head of the pancreas can be anatomically divided into two sections, one drained by the duct of the Santorini system, and the other drained by the ventral pancreatic duct. This study was undertaken to determine whether independent resection of the ventral pancreas drained by the ventral pancreatic duct could be performed safely and effectively, by employing the following method in four patients. First, the duodenum and pancreas were sufficiently separated preserving the mesoduodenum and the posterior pancreaticoduodenal artery. Next, the main pancreatic duct was divided at the papillary portion, and sectioned at its junction with the duct of Santorini, ensuring preservation of the intrapancreatic bile duct. After the ventral pancreas had been detached from the glistening intrapancreatic bile duct, the ventral pancreas was connected with the dorsal pancreas by only the pancreatic parenchyma. The ventral pancreatic resection was completed following the incision of this border. A pancreatic fistula developed in one patient postoperatively, but this healed within 30 days. The hospital stay after surgery ranged from 35 to 58 days, and a good quality of life was maintained in all four patients. Thus, we conclude that ventral pancreatic resection can be safely performed and is especially valuable for treating the increasingly frequent adenomas and borderline malignancies in the main pancreatic duct system of the head of the pancreas.

Adenoma↗

Effective isolation of MPB64 from a large volume of culture filtrate of Mycobacterium bovis BCG Tokyo.

MPB64, a secretory protein of Mycobacterium bovis BCG Tokyo, was isolated from a culture filtrate of the bacteria in Sauton synthetic medium harvested on day 8. The protein was isolated by five steps; (i) concentration of the culture filtrate by cutting the molecules smaller than 5 kDa with the Millipore Pellicon Cassette system, (ii) affinity separation by a Phenyl Sepharose CL-4B column, (iii) separation with a DEAE-Sepharose CL-6B column with 3 M urea, (iv) separation with a Sephacryl S200HR column, and (v) separation with a DEAE-Sepharose column without urea. MPB64 in each fraction was determined by comparing the band in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with that of standard MPB64. The specificity of isolated MPB64 was tested by immunoblotting with anti-MPB64 antibody. The potency of isolated MPB64 in eliciting skin reaction in the BCG-sensitized guinea pigs was the same to that of standard MPB64. The method described herein is an improved one for isolating MPB64 from a large volume of culture filtrate of M. bovis BCG Tokyo. The technique should be applicable to isolation of other mycobacterial secretory proteins.

Antigens, Bacterial↗

[A case of hepatocellular carcinoma with reduction of primary tumor and disappearance of multiple lung metastasis].

A 62-year-old male patient was admitted for spontaneous rupture of hepatocellular carcinoma. He also had multiple lung metastases and liver dysfunction. So neither operation nor trans-arterial embolization could be performed. He had been administered UFT (400 mg/day) orally every day. After 5 months of daily administration, there was complete disappearance of multiple lung metastasis and reduction of the primary tumor. This case suggests that UFT is effective for some advanced hepatocellular carcinoma with extrahepatic metastasis.

Administration, Oral↗

Surgical management for lymph node recurrence of resected fibrolamellar carcinoma of the liver: a case report.

Fibrolamellar carcinoma of the liver (FLC), which is very rare in Japan, is reported to be frequently accompanied by lymph node metastasis in Europe and the United States. We describe a 22-year-old man with recurrent FLC in the lymph nodes after undergoing partial hepatectomy. He underwent a second operation for removal of recurrent lymph node tumors in the mediastinum and abdominal cavity one year after initial surgery. However, a third operation became necessary seven months later, because of recurrence in a lymph node in the abdominal cavity. We discuss the management of lymph node metastasis from FLC.

Adult↗

Primary malignant fibrous histiocytoma of the diaphragm: report of a case.

We present herein the case of a 55-year-old man with primary malignant fibrous histiocytoma (MFH) of the diaphragm. He was admitted to our hospital with right anterior chest pain, where diagnostic imaging showed a huge tumor in the right diaphragm with a tumor thrombus in the vena cava, spreading to the left lobe of the liver and the pericardium. Although invasion into the right lung was identified at the time of surgery, the entire tumor was removed. Histopathological examination of the resected specimen revealed the characteristics of MFH. We discuss the clinical features of this patient in comparison with the few previous reports on MFH of the diaphragm.

Diagnostic Imaging↗

Antipromoting effects of 5-lipoxygenase inhibitors, 3-nitro-2,4,6- trihydroxybenzamide derivatives, on TPA-promoted transformation in BALB 3T3 cells.

In order to discover the role in the promotion process of 5-lipoxygenase (5-LO), a key enzyme in the arachidonate cascade, the antipromoting effects of the 5-LO inhibiting 3-nitro-2,4,6-trihydroxybenzamide (NTB) derivatives were studied in a two-stage transformation assay system using BALB 3T3 cells. All compounds inhibited TPA-promoted transformation in a dose-dependent manner. Most of them achieved a 70-80% inhibition. Good correlations were observed between the inhibition of TPA-promoted transformation and that of 5-LO. These results indicate that 5-LO plays an important role in the promotion stage of the transformation of BALB 3T3 cells.

3T3 Cells↗

Inhibitory effects of 3-nitrophloroglucinecarboxylic acid derivatives on Epstein-Barr virus early antigen induction.

The inhibitory effects of two series of 3-nitrophloroglucinecarboxylic acid derivatives, 3-nitro-2,4,6-trihydroxythiobenzamides (II) and 3-nitro-phloroglucinecarboxylates (III), on Epstein-Barr virus early antigen (EBV-EA) induction were examined using Raji cells. Some of them strongly inhibited the induction, N-nonyl and O-decyl derivatives being the most potent inhibitors among the thioamides and esters, respectively. These results suggest the possibility that these two 3-nitrophloroglucinecarboxylic acid derivatives may be listed as novel inhibitors of tumor promotion.

Antigens, Viral↗

The impact of endometriosis on the reproductive outcome of infertile patients.

OBJECTIVE: We examined whether the presence and severity of endometriosis affect the reproductive outcome of infertile patients. STUDY DESIGN: The conception rates of 2080 infertile women, 1263 who had endometriosis and 817 who did not have endometriosis, were analyzed retrospectively by means of the chi 2 test. Depending on the stage of the disease patients who had endometriosis-associated infertility underwent expectant management, danazol therapy, or minor or major conservative surgery. The patients who failed to conceive after these conventional treatments were enrolled in the in vitro fertilization-embryo transfer program. RESULTS: The conception rates were virtually identical regardless of the presence or absence of endometriosis (30.7% vs 30.0%). The outcome of in vitro fertilization-embryo transfer was not affected either by the presence or the severity of the disease. CONCLUSION: Endometriosis had no impact on the reproductive outcome of infertile patients in this series unless the anatomy of the pelvic organs was heavily distorted, which can occur in the advanced stages of the disease.

Adult↗

Occupational asthma induced by the fungicide tetrachloroisophthalonitrile.

A 48 year old male farmer had recurrent episodes of dyspnoea, shortness of breath, and wheezing after being in his plastic greenhouse when the fungicide tetrachloroisophthalonitrile had been sprayed. A bronchial provocation test with a control challenge and a patch skin test confirmed that his asthma was induced by tetrachloroisophthalonitrile.

Agricultural Workers' Diseases↗

A novel leukotriene antagonist, ONO-1078, inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4 and antigen in vitro.

ONO-1078, 4-oxo-8(-)[p-(4-phenylbutyloxy)benzoylamino]-2-(tetrazol-5-y l)-4H-1-benzopyran hemihydrate, is a novel compound that has been shown to be a leukotrienes C4 and D4 (LTC4, LTD4) antagonist in the guinea pig airways. We studied the ability of ONO-1078 to inhibit and reverse the contraction of isolated human bronchus induced by LTC4, LTD4, and antigen. The human bronchial tissues were prepared from patients undergoing surgery for lung cancer, and they were placed in organ baths. ONO-1078 (10(-8) to 10(-6) M) produced a concentration-dependent inhibition of LTC4 and LTD4 concentration-response curves. In the presence of l-serine borate complex, which inhibits the conversion of LTC4 to LTD4 by gamma-glutamyl transpeptidase, ONO-1078 significantly inhibited the LTC4-induced contraction, suggesting that ONO-1078 is an antagonist of both LTC4 and LTD4. ONO-1078 (10(-6) M) also significantly reversed an ongoing contraction induced by LTC4 (10(-7) M). The inhibitory effect of ONO-1078 on LTC4-induced contraction was at least 100 times more potent than that of FPL 55712, the first discovered LTC4 and LTD4 antagonist. To study the effect of ONO-1078 on the contraction induced by antigen challenge, bronchial tissues were incubated for 2 h with serum of high specific IgE against house dust from an asthmatic patient. House dust antigen was added to the sensitized bronchial tissues after incubation with ONO-1078 (10(-6) M) or histamine H1 antagonist pyrilamine (10(-6) M), either alone or in combination.(ABSTRACT TRUNCATED AT 250 WORDS)

Antigens↗

[Analysis of HLA antigens and immunotherapy for infertile couples who failed to conceive after in vitro fertilization-embryo tubal replacement (IVF-ETR)].

The results of IVF-ETR strongly suggest the existence of implantation failure of unknown etiology. A selected group of 41 couples with long-standing infertility who had one or more failed IVF-ETR cycles were analysed for HLA antigen sharing, and 19 wives were immunized with their husband's purified lymphocytes just before the subsequent trial. Both the number and frequency of shared HLA antigens in these patients were significantly increased, compared with control couples of normal fertility (p < 0.05). After immunization, 7 patients (36.8%) conceived by IVF-ETR, and 5 (71.4%) delivered a healthy baby at term. The pregnant couples shared significantly fewer HLA antigens compared with those who failed to conserve (p < 0.05). Interestingly, the MLR blocking effect was enhanced in the pregnant group after immunization, suggesting the induction of blocking antibodies which are believed essential for the survival of the developing fetus. In contrast, the blocking effect was rather decreased in the nonpregnant group. These results implicate that HLA sharing and inadequate maternal anti-paternal immunity may be related to implantation failure, and immunotherapy can be used to potentiate the maternal immune response, leading to successful implantation in selected patients.

Adult↗

A case of calcifying carcinoma of the stomach with long-term postoperative survival.

A 28 year old man suffering from calcifying carcinoma of the stomach underwent a gastrectomy which was histologically classified as being a noncurative resection. As postoperative adjuvant chemotherapy, he received 116 mg of Mitomycin C and 454.8 g of Tegafur as well as 5690 g of ascorbic acid. He showed carcinoma cells histologically at both oral and anal edges of the resected specimen, and peritoneal metastases of tumor cells were also observed, but he nevertheless kept a performance status of 1 until 5 years after surgery. The patient finally died of cachexia 5 years and 6 months after his operation. Among 42 patients with calcifying carcinoma of the stomach reported in the foreign literature and 19 patients reported in Japanese, those patients for whom the postoperative survival time was clearly indicated did not necessarily survive longer than those patients without calcification.

Adult↗