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Biomedical subjects

I Honda

Publications and source records attributed to I Honda.

At least 73 records · Page 4Linked to original sources
PubMed1987

[Clinical experience with cefuzonam in bacterial infection of children].

Clinical studies were performed on cefuzonam (L-105, CZON), a new cephem antibiotic, as follows. Cerebrospinal fluid (CSF) and serum concentrations. CSF and serum concentrations of CZON were measured in 1 case of septic arthritis without meningitis. One hour after 50 mg/kg intravenous bolus injection, the CSF and serum concentrations were 0.10 and 18.1 micrograms/ml, respectively, and CSF to serum concentration ratio was 0.55%. Clinical efficacy CZON was administered to 15 patients in doses ranging 54.5 approximately 212.4 mg/kg/day (94.1 mg/kg/day on average) t.i.d. or q.i.d. for 4 approximately 12 days (6.5 days on average). Of those patients, 9 were with pneumonia, one each was with bronchitis, with tonsillitis, with septic arthritis, with septicemia, with purulent meningitis and with urinary tract infection. The overall efficacy rate was 100%, i.e., efficacy was excellent in 12, good in 3. Bacteriological efficacy was excellent, i.e., 8 of 8 strains were eradicated. Side effects were observed in 2 cases, i.e., one case with loose stool and another with eruption. Laboratory abnormalities to the drug were not observed during the treatment. The above results suggested that CZON would be a useful antibiotic for treating pediatric bacterial infections.

Adolescent↗
PubMed1987

[Study on the erroneous diagnosis of fine needle aspiration of breast cancer].

A histological examination of the breast tumors in 852 patients, after they had received fine needle aspiration, was performed. The false positive and false negative cases were then studied; 32 false positive and 15 false negative cases respectively. As causes for misunderstanding, five items were pointed out in the false positive cases and three in the false negative ones. There were 5 false positive cases in which cellatypia was remarkable, and 3 false negative cases whose cellatypia was not significant. Cytologic diagnosis by fine needle aspiration for these 8 patients was difficult.

Adult↗
PubMed1985

Nifedipine inhibits human bronchial smooth muscle contractions induced by leukotrienes C4 and D4, prostaglandin F2 alpha, and potassium.

The effects of nifedipine, a calcium channel blocker, on human bronchial smooth muscle contractions induced by leukotrienes C4 and D4 (LTC4, LTD4), prostaglandin F2 alpha (PGF2 alpha), and potassium were studied in vitro. The LTC4, LTD4, PGF2 alpha, and potassium caused bronchial smooth muscle contractions. After incubation with nifedipine at 2.9 X 10(-6)M, the contractions caused by LTC4, LTD4, PGF2 alpha, and potassium were significantly decreased. Nifedipine also significantly reversed human bronchial smooth muscle contractions previously initiated by these agonists. The effect of nifedipine on potassium contraction was significantly greater than that on LTC4, LTD4, and PGF2 alpha-induced contractions. The pharmacologic feature of nifedipine is that it inhibits the calcium influx associated with membrane depolarization. Therefore, these results suggest that there are two mechanisms of calcium movements in human bronchial smooth muscle contractions induced by LTC4, LTD4, and PGF2 alpha: membrane-depolarization-dependent and -independent mechanisms.

Aged↗
PubMed1985

[Collection of human oocytes by percutaneous aspiration using ultrasound].

Ultrasound-guided percutaneous follicular aspiration was performed in 10 patients taking part in our in vitro fertilization and embryo transfer (IVF-ET) program, in which laparoscopic egg retrieval had been recognized to be difficult, due to severe adhesions. Twenty-three follicles with a mean diameter of 23mm were aspirated, and 12 oocytes were recovered, giving a success rate of 52% per follicle. The overall egg recovery rate was 64% (9/14) per procedure. In 7 cases the procedure was carried out under local anesthesia, in 4 cases under subarachnoid block, and in the remaining 3 under general anesthesia. Egg recovery was better under spinal and general anesthesia (6/7) than local anesthesia (3/7). The only complication was a transient hematuria found in one patient. These results suggests that ultrasound-guided follicular puncture is useful for collecting oocytes in the IVF-ET program, when the routine laparoscopic approach is not applicable because of severe pelvic adhesions.

Adult↗
PubMed1984

[Monitoring of the preovulatory follicles--a comparison of ultrasound and laparoscopy].

Accurate prediction of the time of ovulation is important for infertile women considering in vitro fertilization. Preovulatory follicular growth was measured by using ultrasound every 2 to 24 hours and laparoscopic aspiration of the follicular fluid was performed in sixty six patients with clomiphene-HCG cycle. The mature oocyte was examined in aspirated fluid. In ten fertile women with spontaneous cycles, preovulatory follicles were measured by ultrasound and the largest follicular diameter was 18.7 +/- 1.9mm (mean +/- S.D.), of which the growth rate was 1.39mm/day. Follicular diameter was well correlated with the aspirated volume (r = 0.847; p less than 0.001), the largest diameter of the dominant follicle being 28.3 +/- 1.5mm and the second follicle 23.3 +/- 6.1mm. The second follicle grew rapidly after HCG injection and the mature oocyte was collected in spite of rupture of the dominant follicle. The size of the dominant follicle reaching a maximum diameter of 25mm remained almost unchanged for 24 hours before ovulation. The recovery rate of mature oocyte by ultrasound in monitoring of follicles was 87.5%. Ultrasound is a useful technique to use in monitoring follicular growth and ovulation.

Adult↗
PubMed1983

[Clinical evaluation of cefotaxime in internal medicine].

Cefotaxime (CTX) was used for 129 cases in respiratory tract and other infections; 57 cases of pneumonia, 20 cases of bronchopneumonia, 20 cases of acute bronchitis, 14 cases of chronic bronchitis, 7 cases of acute exacerbation of bronchiectasia or pulmonary emphysema, 4 cases of suppurative diseases of the lung, 1 case of pyothorax, 1 case of retropharyngeal abscess, 3 cases of pleurisy and 1 case of urinary tract infection. (A case was excepted on clinical evaluation.) CTX was administered by intravenous injection or drip infusion at a daily dose ranging from 0.5 to 8 g, for a term of 2 to 61 days. The total dose patients received ranged from 3 to 226 g. The results obtained were as follows. Clinical effects; excellent in 45 cases, good in 63 cases, fair in 9 cases, poor in 7 cases and unevaluable in 4 cases. The efficacy rate was 87.1% (108/124). Bacteriological effects; eliminated in 30 cases, decreased in 8 cases, unchanged in 2 cases and replaced in 1 case. The elimination rate was 75.6% (31/41). Side effects and abnormal laboratory findings; general itching, fatigue in lower extremities and albuminuria in 1 case each, and anemia in 2 cases. Increased number of eosinophiles and elevated GOT in 1 case each, elevated GOT and GPT in 3 cases and elevated GOT, GPT and A1-P in 2 cases. These symptoms or abnormal laboratory findings disappeared after the discontinuation or termination of CTX therapy. In view of the above, CTX may be considered to be a clinically useful antibiotic against respiratory tract infections.

Adult↗
PubMed1981

Report of a case of precancerous primary duodenal polyp and a review of the related literature.

A 62-year-old woman with a precancerous duodenal polyp in the suprapapillary region of the second portion of the duodenum was surgically treated by pancreato-duodenectomy. The postoperative course and follow-up was uneventful. A statistical analysis of primary duodenal tumor cases (excluding tumors of the duodenal papilla) reported in Japan during the period from 1962 to 1977 was also reported.

Duodenal Neoplasms↗