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Biomedical subjects

I Horvath

Publications and source records attributed to I Horvath.

29 records · Page 2Linked to original sources
PubMed1987

The effect of EDTA-Fe(III) complexes with different chemical structure on the lipid peroxidation in brain microsomes.

Unlike EDTA-Fe(III) (1:1), the oxidized form of EDTA-Fe(II) complex enhanced lipid peroxidation in brain microsomes. Mossbauer spectroscopy and electron paramagnetic resonance analysis of oxidized EDTA-Fe(II), capable of inducing lipid peroxidation, showed the presence of EDTA-Fe(III) complex, which was different from the separately prepared (not oxidized) EDTA-Fe(III). Lipid peroxidation initiated by the oxidized EDTA-Fe(II) complex was dependent on the presence of NAD(P)H and functionally intact microsomes. No inhibitory effect was found by generally used free radical scavengers and catalase. Our results clearly indicate that the chemically different EDTA-Fe(III) complexes differ in their capability of initiating the NAD(P)H-dependent lipid peroxidation in brain microsomes.

Animals↗
PubMed1987

The inhibitory effect of succinate on radiation-enhanced mitochondrial lipid peroxidation.

The degree of mitochondrial ADP/Fe/NADPH-induced lipid peroxidation was increased up to the fourth day after 9.0 Gy whole body gamma-irradiation. The lipid peroxidation inhibiting effect of succinate added to isolated mitochondria was diminished as a consequence of irradiation. The succinate, administered in vivo prior to irradiation, decreased the amount of malondialdehyde production and protected the succinate dehydrogenase enzyme against inactivation. The mean survival of succinate-pretreated animals was much longer than that of controls. The role of mitochondrial lipid peroxidation in the pathogenesis of radiation injury is discussed.

Adenosine Diphosphate↗
PubMed1980

Experimental syphilis and serological examination for treponematosis in hares.

Of 202 captive hares studied, many of which had lesions on their external genital organs or testicular atrophy or both, 27% had positive serological tests for syphilis although dark-field examination of extracts of atrophic testes was negative. A total of 12 hares that were nonreactive for the serological test for syphilis was inoculated with Treponema pallidum, 9 intratesticularly and 3 intradermally. Six of the animals inoculated intratesticularly exhibited orchitis after 7 days with an associated accumulation of treponemes. No chancres developed in the intracutaneously inoculated animals during a 27-day period of observation. These results provide additional evidence to support the contention that endemic treponematosis occurs in wild hares and suggest that hares are moderately resistant to experimental infection with T. pallidum.

Animals↗
PubMed1979

Isolation of pathogenic treponemes from hare.

A presumably new species of pathogenic treponemes was isolated from a lesion on the male organs of hare (Lepus sp.) and the scrotum of a rabbit (Oryctolagus sp.) was infected with this treponeme. Lesion developed on the scrotum after a 110-day incubation.

Animals↗
PubMed1975

Effects of oxygen and nitrogen on the character of T. pallidum is subcutaneous chambers in mice.

Nitrogen and oxygen gases were injected into mouse subcutaneous chambers which contained virulent Treponema pallidum. The effect of each gas on the viability and survival of T. pallidum in an in vivo system was determined. In comparison with the effects in nontreated control mice, injection of nitrogen enhanced both motility and survival time, but oxygen exerted a deleterious effect.

Animals↗
PubMed1967

Induced phenotypic resistance to valine in Mycobacterium pellegrino.

Valine coordinately increases the levels of three of the enzymes participating in the biosynthesis of isoleucine and valine in Mycobacterium pellegrino. The amount of valine required for end-product induction depends on the condition of the cells. Isoleucine inhibits the effect of valine. Acetohydroxy acid synthetase, the enzyme catalyzing the first common step in the biosynthesis of valine and isoleucine, is inhibited by valine. The induction effect of valine appears to be due to its ability to inhibit the activity of this enzyme, thus causing isoleucine deficiency, which in turn leads to derepression. This conclusion is supported by the fact that valine, under certain conditions, inhibits growth.

Enzyme Repression↗
PubMedDate not supplied

[Jaundice with indirect bilirubinemia via the mother's milk].

Among the clinical entities included in the differential diagnosis of the prolonged jaundice at the end of neonatal period and in the small infant is the jaundice due to mother's milk, whose incidence is of 0.5-2% in the naturally fed infants. The authors present two cases in which the diagnosis was reached by exclusion and confirmed by the therapeutically positive test. Physiopathologic considerations are made on the basis of the literature data, and the nosologic background of the affection is presented. This clinical entity, considered to have an excellent prognosis, presented a special evolution in one of the cases.

Diagnosis, Differential↗