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Biomedical subjects

I Horven

Publications and source records attributed to I Horven.

At least 19 recordsLinked to original sources

Ocular blood flow changes in cluster headache and chronic paroxysmal hemicrania.

Intraocular pressure and pulsatile ocular blood flow were recorded during and between attacks in patients suffering from cluster headache (n = 18) or chronic paroxysmal hemicrania (n = 7). Similarities, as well as significant differences, were observed between the two groups of patients, pointing to fundamental differences between the two disorders with regard to pathophysiology. Compared with healthy controls, the cluster headache patients demonstrated low pulsatile ocular blood flow values between attacks, with an increase to normal levels during pain. The chronic paroxysmal hemicrania patients, however, had normal values between attacks with a marked and significant increase to high values during attacks.

Adult

Cluster headache syndrome and migrain. Ophthalmological support for a two-entity theory.

Patients suffering from migraine, cluster headache and atypical cluster headache, including patients with chronic paroxysmal hemicrania, were studied with respect to corneal temperature, intraocular pressure and corneal indentation pulse amplitude changes during pain attacks. Significant rises in these three parameters were deomonstrated during attacks of cluster headache and atypical cluster headache, indicating that intraocular vasodilation with increased ocular blood flow occurs during attacks. No definite changes were found in migraine. The results strongly suggest that significant pathophysiological differences exist between migraine and cluster headache. The point is stressed that these disorders probably represent separate pathogenetic entities and should be classified as such, and not be grouped together within an ill-defined group of "vascular headache".

Adult

Blood circulating changes in the eye and limbs with relation to pregnancy and female sex hormones.

Alterations in corneal indentation pulse (CIP) amplitudes and pulse volume recordings (PVR) on the limbs were demonstrated in pregnant women, indicating that significant changes occur in the peripheral blood circulation during pregnancy. The PVR measured at week 30-36 of gestation demonstrated a significant increase when recorded on the forearm and index finger. In the eye an increase in CIP amplitudes was found early in pregnancy. From week 20 on, however, a steady decrease occurred, until the CIP amplitudes at term averaged about 1/3 of the values from normal, non-pregnant women. Similar changes, although less pronounced, were demonstrated in the ocular blood circulation during oral contraceptive treatment and, to some extent, during menstruation. Intake of gestagens and diaethyl-stilboestrol did not alter the CIP amplitudes.

Adolescent

Contact probe for corneal temperature measurements.

A thermistor probe for corneal temperature measurements is presented. The temperature-sensing cartridge is similar in shape to an electronic tonometer, and the procedure of corneal temperature registration is performed just as easily and in a similar manner as for tonography.

Cornea

Corneal temperature in normal subjects and arterial occlusive disease.

A direct, thermo-electrical method of corneal temperature recording is presented. The corneal temperature averaged 33.7 degrees C in normal subjects, with no side difference and no difference between the sexes. The various parameters which may influence the corneal temperature are discussed. The technique was applied to groups of patients suffering from either polymyalgia rheumatica, central retinal artery embolism or temporal arteritis. In the latter group of patients a marked drop in corneal temperature was demonstrated in the affected, or most affected, eye. Corneal temperature measurements are therefore presented as an easy and effective diagnostic approach in temporal arteritis.

Adult