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Biomedical subjects

I Huk

Publications and source records attributed to I Huk.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Duplex sonography after femoro-distal vascular reconstruction using umbilical veins].

In 34 patients femoro-distal reconstructions with umbilical vein grafts were assessed by means of pulsed Duplex sonography. Dilatations of the grafts and aneurysms were diagnosed easily by means of DS, likewise thrombotic plaques and perivascular pathologies. Haemodynamically significant stenoses can be quantified due to the increased velocity measured by pulsed Doppler. It can be concluded that DS is the method of choice for the postoperative follow-up of umbilical vein grafts of the femoro-distal vascular system.

Aged↗
PubMed1989

[DSA and duplex sonography of aortic prostheses].

In 95 patients with aortal grafts, DSA was compared with duplex ultrasonography. In 4 patients the graft was better visualized by means of angiography. Kinking, coiling, dilatations, pseudoaneurysms, stenoses, and occlusions could be sufficiently diagnosed with both methods. Marginal thrombosis and periprosthetic pathologies could only be found with ultrasonography. The ultrasonographic and angiographic examination techniques are described and the limitations of both methods discussed.

Adult↗
PubMed1988

Vein bypass surgery for femoro-popliteal arteriosclerosis: influence of different risk factors on patient survival and the importance of anticoagulant treatment.

For femoro-popliteal arteriosclerosis the autologous saphenous vein graft implanted in reverse has evolved as the standard procedure, but the impact of postoperative anticoagulant treatment upon patient survival in particular remains uncertain. Patients undergoing elective surgery during the years 1970-86 (n = 668) were analysed using Kaplan-Meier estimates. This demonstrated that the preoperative status of the patient exerted a significant influence on the probability of survival (P less than 0.0001 Mantel). Anticoagulants started postoperatively significantly prolonged the life of the patients (P less than 0.0001). Of the various risk factors the patient's age had the most important influence (P less than 0.0001), whereas the presence or absence of diabetes mellitus (P less than 0.064) and the duration of the operation (P less than 0.407), were not significant. Using the proportional hazards regression model to test the validity of a prognostic factor, while other variables were checked, we found preoperative clinical status (P less than 0.0001), the patient's age (P less than 0.0001) and anticoagulant treatment (P less than 0.0001) to be of statistical importance.

Age Factors↗
PubMed1987

[Role of postoperative anticoagulant treatment following femoro-popliteal venous bypass. Interim evaluation of a controlled clinical study].

Eighty-eight patients underwent a classical reversed saphenous vein graft for femoro-popliteal occlusive disease and were enrolled in a controlled clinical trial. During the second postoperative week the patients were allocated randomly into one of two groups: group I consisted of 42 patients who received dicumarol and group II (46 patients) served as a control group without any anticoagulant treatment. The mean follow-up time was 24 months. After 12 months the cumulative patency rate was 82%, after 18 months 76% and after 24 months 76%; for patients receiving dicumarol treatment the respective figures were 92%, 86% and 86% and for those with no treatment 70%, 67% and 67%, the difference being significant. When the bypass operation was performed for limb salvage (clinical stages III and IV) the overall results were worse (12 months: 72%, 18 months: 68%, 24 months: 68%) than in stages II, II-III (12 months: 90%, 18 months: 85%, 24 months: 85%). In limb salvage surgery the positive effects of anticoagulant treatment were significant (with treatment: 12 months 87%, 18 months 86%, 24 months 86%; without treatment: 12 months 58%, 18 months 54%, 24 months 54%).

Aged↗
PubMed1986

[Autologous venous bypass in the therapy of arterial occlusive disease of the femoropopliteal area: long-term results].

The outcome of 532 femoro-popliteal vein grafts performed electively during the years 1970 to 1985 for obliterative arterial disease, was analyzed using the documentation-system of the Austrian Society for Vascular Surgery, as well as SAS and BMDP-software on an IBM 4381 computer of the Medical Faculty. The probability of function was estimated according to the Kaplan-Meier method, statistical differences were checked with Breslow's and Mantel's test, the proportional hazards regression model (Cox) was used to elucidate the influence of different risk factors on each own and in combination of each other. In the univariate analysis, the preoperative clinical status was found to be of prognostic significance, but technical details such as intraoperative as well as postoperative arteriography or site of the distal anastomosis were not important. A postoperative coumarine treatment had no demonstrable impact on graft function, but positively influenced the probability of patient survival. Taking into account the factors found to be of significance in the univariate analysis (e.g. set of factors: site of distal anastomosis, diabetic state and smoking habits) were analyzed using the proportional hazards regression model but were found of no major influence. The factors preoperative clinical status, patients age, and coumarine therapy significantly influenced the probability of patient survival, but diabetes mellitus and smoking were found to be not important.

Aged↗
PubMed1986

Cholesterol: an antidiarrheal agent in rats with short-bowel syndrome fed elemental diets.

Studies show that bile acids and long-chain fatty acids are responsible for diarrhea in certain malabsorption syndromes. Recent reports indicate that substances such as dietary cholesterol, when moderately consumed, can reduce bile-induced excessive mucosal fluid and electrolyte output. This study explores the antidiarrheal effect and dosage of dietary cholesterol in rats following massive bowel resection, co-fed elemental diet. Thirty-five male Sprague-Dawley rats weighing 248-253 g underwent 75% resection of the small bowel and were fed ad libitum for 21 days with 1 of 5 diets (n = 7) of Vivonex HN, supplemented by 0, 2.5, 5, 10 or 15 mM cholesterol/1,000 g of the powdered elemental diet. Parameters measured included daily food and water consumption, daily changes in weight, volume of excrement and stool consistency graded by the same individual (water, semiformed or formed). It was found that 5 mM dietary cholesterol in 1,000 g of the elemental diet produced the most formed stool and significantly improved weight gain in rats with short-bowel syndrome.

Animals↗
PubMed1984

Postoperative infections in colonic surgery after enteral bacitracin-neomycin-clindamycin or parenteral mezlocillin-oxacillin prophylaxis.

In a prospective randomized, blind trial, three groups of patients undergoing elective colonic surgery were compared for frequency of surgical wound infection, intra-operative wound contamination and other postoperative infections. All patients allotted to the three groups received whole gut irrigation (101 balanced salt solution) by gastric tube on the evening before surgery and were treated as follows. Group A: no antibiotics; Group B: neomycin (1 g/l) + bacitracin (50,000 IU/l) + clindamycin (900 mg/l), contained in the last 31 of irrigation fluid; Group C: mezlocillin (4 g) + oxacillin (2 g) intravenously (iv) at induction of anaesthesia, followed by two identical doses at 8 and 16 h. The rate of postoperative wound infection was highest in A (38 per cent) and much lower in B (3.3 per cent, P less than 0.002) and C (6.9 per cent, P less than 0.004). The difference between B and C was statistically not significant. In A a correlation was established between the degree of wound contamination and the occurrence of wound infection. Intra-operative wound contamination was lowest in B (30 per cent), equal in A (58.1 per cent) and B (55.2 per cent). Other infections were least frequent in group C (four of 29 patients), but were not significantly different to groups B (six of 30) and A (nine of 31). It is concluded that antibiotics together with an effective mechanical preparation considerably reduce the rate of wound infection in colonic surgery.

Adult↗
PubMed1984

A new method for long-term intravenous alimentation in unrestrained rats.

A new technique for continuous long term intravenous alimentation in unrestrained rats has been developed. The model involves the use of the intravenous tubing set which was constructed from the barrel of a 1 ml syringe-cylinder with flanges sutured to the rat's skin. After inserting the silicone catheter into the jugular vein the free end was exited at the intraauricular area and passed through the intravenous tubing set. The tubing was then connected with a silk suture to the top of the cage. This prohibits twisting of the system and allows unrestrained movement of the rat in the cage with a rotation of 6-8 turns in either direction. The metabolic cage was constructed from an inverted 4-liter glass jug with the base removed. A floor and root were fashioned from coarse wire screen. Urine and feces were easily separated and collected through the neck of the jug. This new "proxy" set was tested and compared with the standard swivel assembly parameters in rats infused by either method. However, the cost of the new set (excluding pump) was almost 90 times less than its commercially available counterpart. This self constructed approach should bring small animal research within the economic means of the most investigators.

Animals↗
PubMed1983

Extended extraanatomic arterial reconstruction: subclavian artery-bifemoro-crossover-popliteo-tibial-PTFE-bypass.

In a high risk patient an extended extraanatomic PTFE (ring armored) bypass was performed for limb salvage. The right subclavian artery served as donor vessel to the left tibial anterior artery in a crossover suprapubic fashion. A total of 7 anastomoses in this subclavian bifemoro-crossover popliteo-crural reconstruction yielded a high flow situation as well as good function with a palpable dorsalis pedis artery pulse and a postoperatively increased ankle-brachial pressure index of 0.9, 8 months postoperatively. During the 9th postoperative month the distal part of the reconstruction occluded and the left leg was amputated below the knee. However, limb salvage was achieved for 9 months. Several points are discussed in connection with long-term functioning.

Arteriosclerosis↗