[Morphological and biochemical characteristics of the facial skin of middle-aged women].
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Adult↗
Biomedical subjects
I I Bogatyreva
Publications and source records attributed to I I Bogatyreva.
[Morphologic features and biological properties of melanomas in children].
A complex morphologic study was made of primary skin melanoma, its metastases to the lymph nodes in a boy of 8, as well as of the tumour inoculate from the lymph node of the child on nude mice BALB/c in passages 1-6, 9, 10 and 44. The mitotic regimen of the material was studied. The data obtained show that childhood and adult melanoma is characterized by the same clinical-morphologic features. The electron microscopic study provided additional information for the confirmation of the histogenesis and identification of the melanoma type. To study individual sensitivity to antitumour drugs, it might be more reasonable to use first passages of the tumour, as the ultrastructural cell differentiation in them is maximally similar to the original one.
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[Differential diagnosis of basalioma and metatypical skin cancer].
The WHO histological classification of skin tumors (Geneva, 1980) has first distinguished a new nosologic variety of skin carcinoma, metatypic carcinoma (MTC) being intermediate between basalioma and squamous cell carcinoma. Separation of MTC from the group of basaliomas is important prognostically because this tumor is capable of metastasizing, whereas MTC diagnosis is difficult because it simulates basalioma clinically and morphologically. The study of the mitotic regimen in 13 cases of MTC and 20 cases of basalioma showed this method to be adequate for differential diagnosis of these tumors. The values of the mitotic regimen in MTC always differed from similar values in basalioma: the mitotic activity, the specific content of dividing cells at the stage of metaphase, and the rate of pathologic mitoses increased considerably, there appeared multipolar and monocentric mitoses, bridges, three-phase metaphases.
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