[Effect of hormones on water-electrolyte metabolism].
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Biomedical subjects
Publications and source records attributed to I I Dedov.
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An electron-microscopic study was made of the suprachiasmatic and acurate nuclei of the hypothalamus, the intermediate and anterior lobes of the hypophysis in infertile female rats, sterilized by one injection of testosterone propionate in the critical period of their sexual development. Deformed synapses were detected on the bodies of the neurocytes of the suprachiasmatic nucleus, the accumulation of secretory granules and synaptoid vesicles in the nerve terminals of the intermediate lobe, and an intensive formation of secretion by the prolactin-producing adenocytes of the hypophysis. The mechanism of the masculinizing effect of androgens at the level of the hypothalamus and the possibility of correction of the anovulatory cycle in sterile females are discussed.
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The data are presented characterizing changes in some locomotor activity indices and the sex hormone level of the rat blood plasma during a process of experimental neurosis development, i. e. during a prolonged sexual conflicting situation. Persistence and predisposition to the emotional stress arising were observed in the animals under study.
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In a experiment on female rats lasting two years, the influence of total gamma radiation if a dose of 100 rad on the state of the neuroendocrine system was studied. Penetrating radiation causes a disturbance of the hormonal balance and of the sexual cycle, and, as a consequence, the development of tumors of the incretory glands and target organs.
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