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Biomedical subjects

I I Kalinina

Publications and source records attributed to I I Kalinina.

At least 19 recordsLinked to original sources
PubMed2005

Embryological approach to studies of stem cells.

Based on the findings of their own studies on embryonic histogenesis of human tissues and published reports, the authors determined the time limits of the existence of human embryonic stem cells and type of their determination in divergent development of tissues in different organs. Realization of genetic information of embryonic stem cells during tissue embryogenesis was studied. This information is realized by the cambium. Variability of all tissue processes is possible only within their own embryonic primordium; prospects of the mesenchyma development in an adult body is discussed.

Embryo, Mammalian↗
PubMed2003

Thymalin in developing respiratory organs of human fetus.

We studied the appearance of immunomodulator thymalin in human respiratory organs during early embryogenesis. Thymalin accumulated in young cells of airway epithelium. In the alveolar part thymalin-positive cells were diffusely spread. Mature T cells (CD3+) and the main regulatory elements (CD4+ and CD8+) were detected during the same period in the lungs in the absence of thymic microenvironment. The function of immune elements forming in fetal lungs is local protection of the fetus from potentially aggressive maternal cells and infectious agents entering the body through the trachea and fetal blood vessels.

Adjuvants, Immunologic↗
PubMed2002

Thymic hormones in human fetal skin epidermis.

Thymic hormone thymalin is detected in young epidermal cells of human fetuses. Its content varies with gestation age. Maturation of keratinocytes in the epidermis is paralleled by a decrease in the population of young thymalin-positive cells. By birth they are located on the basal membrane and in some adjacent layers. This regularity was seen in different parts of the body.

Epidermal Cells↗
PubMed2002

Age-related changes of thymalin content in human epidermis.

Immunomorphological analysis revealed the presence of thymalin in human epidermis and in fetal reticuloepithelium. These structures are developed from the common embryonic primordium ectoderm. In embryos and adult humans thymalin is present only in young epidermal cells, which undergo age-related involution. By the age of 70 years, the layer of thymalin-containing cells looks thinned and discontinuous. The content of thymalin, a thymic factor, decreases with age.

Adult↗
PubMed2002

[Immunologic characteristics of the thymus of aged CBA mice after implantation of human fetal tissue].

The effect of human fetal tissues (hypothalamic, liver, spleen, adrenal, ovarian, testicle, uterine, prostatic, gut, placental cells) collected from the fetuses at the 16-22 weeks of prenatal development, on the cytological structure of the thymus of 2-years old CBA mice in 7, 14, 42 and 64 days after start of treatment has been studied using morphological and immunological methods. The data obtained suggest that the implantation of human fetal tissues does not stop totally, but postponed age involution of thymus.

Aging↗
PubMed2000

Development of endocrine and lymphocytopoietic functions of the thymus in human embryogenesis.

The endocrine function of the thymus develops earlier than lymphocytopoietic. Thymalin is produced by epithelial cells in the thymus primordium. It is released into the blood and regulates differentiation of T lymphocytes in the liver, the initial hemopoietic organ. The hormonal and lymphopoietic functions of human thymus are united on weeks 7.5-8 of embryonic life.

Epithelial Cells↗
PubMed1989

[The dynamics of thymalin localization in human thymus cells in embryogenesis].

Immunofluorescence methods were applied to study the localization of the thymalin-containing cells in human thymic epithelium of 6-23-wk-old fetus and 2-3-yr-old infants. The study of the fetal thymus (6 weeks) showed the presence of thymalin in reticuloepithelial framework. These cells were present in both in the cortex (in subcapsular regions) and in the medulla; Thymalin-containing cells presence--in the Hassall's corpuscles (23 weeks). The same results were obtained with the infants thymus (3-yr-old).

Child, Preschool↗
PubMed1983

[Thymocyte differentiation in mouse embryogenesis].

Thymocytes in mouse embryogenesis and their capacity for colony formation in the spleen of irradiated mice were studied by electron microscopy and immunoassay. Thymocytes from 13-day-old mouse embryos were found to have large nuclei with diffuse chromatin and 1-2 nucleoli. The cytoplasm of these cells was found to contain ribosomes, mitochondria and Golgi's complex. These lymphocytes possess colony forming capacity and are not lysed by anti-theta-serum. In 15-day-old mouse embryos, theta-antigen shows on the cell surface, while the number of colonies in irradiated recipient' spleens decreases. In 17-day-old embryos, thymocytes acquire the structure and properties common to mature T cells.

Animals↗
PubMed1979

[Ultrastructure and antigens in differentiation of thymus lymphocytes in human embryogenesis].

Thymus lymphocytes of 7--8-week human embryos have nuclei of irregular form with 1--3 distinct nucleoli characterized by absence of compact chromatin or heterchromatin. The electron-dense cytoplasm of these cells contains polysomes and an insignificant number of mitochondria. No receptors to sheep red blood cells and T antigen are revealed on their surface. In 11--12-week human embryos one can observe a decrease in the size of thymus lymphocytes, appearance of heterochromatin in their nuclei and receptors to sheep red blood cells (79%), and T antigen (60%) on the cell surface. Subsequently the quantity of compact chromatin in thymus lymphoid cells increases, and the cells acquire definitive properties and structure.

Antigens, Surface↗