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Biomedical subjects

I I Kolker

Publications and source records attributed to I I Kolker.

At least 19 recordsLinked to original sources
PubMed1987

[Nonclostridial obligate anaerobes--the main causative agents of lung abscesses].

The use of the anaerobic technique in bacteriological investigations has made it possible to establish the leading role of asporogenous anaerobes in the etiological structure of the causative agents of pulmonary abscesses. Asporogenous anaerobes have been isolated from 93% of all examined patients, and in 54.4% of such patients these microorganisms have proved to be an independent etiological factor. Among asporogenous anaerobes, the main causative agents of pulmonary abscesses have been found to belong to four genera: Bacteroides, Fusobacterium, Peptococcus and Peptostreptococcus. Pulmonary abscesses of purely aerobic etiology are rather rare (5.3%). The schemes of the antibacterial treatment of patients with pulmonary abscesses, developed with regard to the leading etiological role of asporogenous anaerobes and clinically approved, have permitted achieving a considerable improvement in the results of treatment and an essential economic effect.

Anti-Bacterial Agents↗
PubMed1986

[RNA synthesis during neutrophil activation].

By means of electron-microscopic radioautography RNA synthesis in blood neutrophils of burn patients was studied. Activation by phagocytic subjects was found to increase overall level of RNA synthesis in blood neutrophils either by increasing the number of cells capable of synthesis, or increasing their number in line with the intensification of the process in each of these cells. Alteration of activation conditions influences the degree of RNA synthesis by both of these means. Wound neutrophils are activated cells with a high level of RNA synthesis and low compared to blood cells, level of protein synthesis and increased capability of adhesion as well. They contain in their numerous phagosomata tissue detritus more frequently than bacteria do. Wound neutrophils are subjected to rapid destruction; it is not possible to stimulate in them phagocytic activity by means of opsonized Pseudomonas aeruginosa.

Autoradiography↗
PubMed1986

[Vacuum treatment in the surgical management of suppurative wounds].

Vacuum treatment was used in 116 patients with purulent wounds. It was established that the vacuum treatment of purulent wounds was effective but after surgical treatment. It considerably decreased the amount of microbes in wound tissues, had no harmful effects and improved clinical results of healing the wounds after putting early sutures.

Bacterial Infections↗
PubMed1985

Vaccines against Pseudomonas aeruginosa infection: 2. Clinico-immunological investigations.

A new multicomponent Pseudomonas vaccine 'pyoimmunogen' has been developed. It was tested for safety and immunogenicity by immunization of volunteer donors and burned patients. Immune plasma obtained from volunteers was used for treatment of severe forms of P. aeruginosa infections. Pyoimmunogen was shown to be of low toxicity for apparently healthy humans and to induce specific antibody formation. In 16 out of 20 burned patients it had a beneficial effect on the course of the disease and the period of hospitalization was shortened. As a result of complex treatment involving the use of anti-P. aeruginosa plasma 51 out of 60 patients recovered.

Adult↗
PubMed1985

[Present-day aminoglycosides in the treatment of suppurative-septic diseases].

The therapeutic efficacy, tolerance and pharmacokinetics of sisomicin, gentamicin and a new dosage form of kanamycin sulfate as an ampoule solution for intravenous injection were studied clinically. High therapeutic efficacy of the above three aminoglycosides in the treatment of severe inflammatory infections caused by gram-negative bacteria was shown with the use of the adequate doses. Favourable results of the therapy estimated by the laboratory and clinical data were observed in 81-90 per cent of the patients.

Adult↗
PubMed1982

[Electron microscopic and autoradiographic study of the interaction of human polymorphonuclear leukocytes and staphylococci].

Leukocyte suspensions of normal subjects and patients with burns and wounds were incubated with Staphylococcus epidermidis and incorporation of 3H-uridine into leukocytes and bacteria was examined by electron microscopic autoradiography. As the maturation of the precursor cells of polymorphonuclear leukocytes (PMNL) progressed the level of RNA synthesis in them was found to decrease gradually and in PMNL RNA synthesis ceased completely. If PMNL take part in phagocytosis, however, RNA synthesis is found in a considerable number of them. The results indicate that RNA synthesis in PMNL is associated with the formation and functional condition of primary and secondary granules. Certain conditions affecting the viability of staphylococci ingested by phagocytes are described.

Autoradiography↗
PubMed1979

[Problems of the immunoprophylaxis of experimental Pseudomonas pyocyanea wound sepsis].

An experimental study showed that a multicomponent Pseudomonas aeruginosa preparation, developed by the authors and named "Pyoimmunogen", had a pronounced protective effect against the culture of P. aeruginosa, most frequently isolated in surgical clinics. The immunization of rats carried out in accordance with a specially devised scheme allowed to decrease mortality rate in experimental pyocyanic wound sepsis to 6.9%, whereas in the control animals mortality rate reached 91.5%.

Animals↗