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Biomedical subjects

I I Protas

Publications and source records attributed to I I Protas.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Neurologic semeiotics of Jakob-Creutzfeldt syndrome].

The paper is concerned with the results of a clinicomorphological analysis of 17 cases of Creutzfeld's-Jacob disease (CJD) in patients aged 39 to 78 years. The authors show polymorphism of the clinical manifestations at the early stages of the disease and the necessity of differentiation between atherosclerotic dementia and tumors of the profound parts of the brain and sometimes with the high pattern of lateral amyotrophic sclerosis. The problem of the clinical varieties of CJD is discussed.

Adult↗
PubMed1990

[Experimental generalized herpes simplex in guinea pigs with retrobulbar infection].

Modelling of generalized herpetic infection of Guinea pigs is described. It took the course in the form of acute or subacute recurring process with either involvement of separate internal organs, or disseminated involvement of all visceral organs, or principal involvement of subcortical structures of the brain, or involvement of the brain and spinal marrow and marked vegetative failures. Signs of vasculitis; development of disseminated intravascular coagulation (DIC) syndrome and CNS demyelinization are detected in animals during the terminal period.

Acute Disease↗
PubMed1988

[Variants of herpetic encephalomyelitis].

The article presents the results of combined clinico-morphological, virological, and seroimmunological studies in 10 patients aged 16 to 57 years who suffered from acute herpetic encephalomyelitis. The authors have identified 4 clinical syndromes: Landry's ascending paralysis, meningomyelitis, disseminated encephalomyelitis, and brain stem encephalitis. Some aspects of the pathogenesis of herpetic lesions of the central nervous system are discussed.

Acute Disease↗
PubMed1987

[Antigenic polymorphism in amyotrophic lateral sclerosis].

HLA-antigen distribution in 93 patients with amyotrophic lateral sclerosis did not differ from that in the control group. Yet, there were significant differences in antigen levels both between different variants of the disease and as compared to the control values.

Adult↗
PubMed1987

[Epidemiological research in amyotrophic leukospongiosis].

The epidemiological aspects of amyotrophic leukospongiosis (AL), a slow viral infection of the central nervous system leading to the fatal outcome in 2-4 years, have been studied. As a rule, this disease is observed in the inhabitants of rural areas or in town dwellers born in rural areas and having spent there a considerable part of their life. AL occurs in persons of middle and older age; young people under 19 years and old people over 68 years of age are not affected by this infection. In contrast to amyotrophic lateral sclerosis and the Jakob-Creutzfeldt disease, AL is characteristic for persons in the phase of hormonal activity. The disease starts mostly in autumn and winter; this regularity is especially pronounced in women. The morbidity level (according to the average annual data) is at present 0.3 per million of population. An increased morbidity rate is characteristic of the family and group type of the epidemic process. This higher morbidity rate, by one order higher than that observed in the sporadic type of morbidity, is caused by the gradual formation of "genetic isolates".

Age Factors↗
PubMed1987

[Development of laboratory diagnostic methods for slow infections of the human central nervous system caused by nonclassical viruses].

The theoretical foundations of the laboratory diagnosis of Creutzfeldt-Jakob disease and amyotrophic leukospongiosis in living patients are discussed and practical diagnostic methods are proposed on the basis of the study of the biological properties of nonclassical viruses and the pathogenesis of slow infections of the central nervous system. The use of the retrobulbar method of infecting susceptible animals has permitted, besides a considerable decrease in the incubation period in modeling slow infections, the improvement of the in vivo biological test. Thus, as the result of the multiplication of non-classical viruses in the visual nerve and the retina, experimental animals develop retinopathy which can be detected 1.5-2.5 weeks after the animals are injected with the spinal fluid or blood taken from the patient under examination. To diagnose amyotrophic leukospongiosis, the in vitro biological test, based on the capacity of the causative agent for inducing a considerable (2- to 5-fold) increase in the mitotic activity of HEp-2 cells, has been developed. The comparative studies have shown the expediency of using the method for the detection of antibodies to nerve-fiber proteins as an additional test for the differential diagnosis of slow infections of the central nervous system.

Animals↗
PubMed1987

[Subacute sclerosing panencephalitis in adults (clinico-morphologic study)].

Analysis of seven cases of subacute sclerosing panencephalitis in adults has revealed several clinical and morphological characteristics of this disease. The results indicate a tendency toward a chronic course of the process, the primary nature of ganglionic cell damage and the secondary nature of demyelinization, as well as a diagnostic value of the immunoperoxidase method in studying the central nervous system.

Adolescent↗
PubMed1985

[Pathologic anatomy of the central nervous system in subacute spongiform encephalopathy (Creutzfeldt-Jakob disease)].

The analysis of 7 cases of subacute spongiform encephalopathy, the Creutzfeldt-Jacob disease (CJD), is given. Three main morphological features are typical for this disease: spongiform change of the grey matter, progressive neuronal loss and proliferation of the astroglia cells. Unlike the other spongiform conditions, spongiform change in the CJD develops in neuropile of the brain grey matter. As a rule, the disease affects at first the cortex of the cerebral hemispheres, then subcortical nuclear groups, cerebellum and more rarely nuclear groups of the brain stem. The demyelinization of the white matter of the cerebral hemispheres is not obligatory for the CJD and appears in cases with a severe lesion of the grey matter.

Adult↗
PubMed1985

[Ultrastructural changes in the CNS in amyotrophic leukospongiosis].

Various types of cells in the human spinal cord and brain, status spongiosus of the white matter of the spinal cord were studied by electron microscopy; the comparison was made to the status spongiosus in monkeys with experimental amyotrophic leukospongiosis. The alterations in the motor neurons of the spinal cord, pyramidal neurons of the brain hemisphere cortex and cerebellum ganglious neurocytes were revealed. Changes in some cells (astrocytes, olygodendrocytes) were characterized. The possibility of a primary axon damage in this disease is discussed.

Animals↗
PubMed1985

[Clinical and experimental amyotrophic leukospongiosis (progressive spinal amyotrophy)].

The authors succeeded in reproducing amyotrophic leukospongiosis in experiments on two squirrel monkeys 16-23 months after challenge with cerebral suspension obtained at autopsy from a human patient. The clinico-morphological studies showed the similarity of the disease in humans and monkeys. A previously unknown agent belonging by its properties to "slow" viruses was isolated. The successful reproduction of amyotrophic leukospongiosis under experimental conditions proved its infectious nature.

Animals↗