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I I Protas

Publications and source records attributed to I I Protas.

63 records · Page 4Linked to original sources
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[Viral retrograde-like pattern of neuronal degeneration in experimental amyotrophic leukospongiosis].

The pattern of destructive alterations of neurons and their processes at different spinal cord levels in guinea pigs with experimental amyotrophic leukospongiosis (AL) was studied by light and electron microscopy. The destruction of a portion of neurons was found to be of retrograde degeneration type. Electron microscopy of spinal conduction pathways showed that degenerative alterations occurred not only in the neuronal soma or processes but also in synaptic structures. The results indicate primary involvement of nerve cell processes, particularly axons, in experimental AL. It is suggested that AL pathogenesis is pathomorphologically based on the uptake of the agent by axonal terminals.

Animals↗
PubMedDate not supplied

[Reproduction of amyotrophic leukospongiosis in laboratory animals].

Amyotrophic leukospongiosis (ALSP) was produced in laboratory animals: hamsters, rabbits, guinea pigs. Guinea pigs were found to be a most suitable laboratory model for the study of ALSP pathogenesis with the longest incubation period. The data are obtained verifying the role of previously isolated unconventional virus in the ALSP etiology.

Animals↗
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[Characteristics of the etiological agent of human amyotrophic leukospongiosis].

Primary cultures of brain cells from a patient with amyotrophic leukospongiosis (ALSP) and animals with the experimentally reproduced disease yielded an agent which by its physicochemical and molecular biological properties was placed among nonclassical viruses, the agents of spongiform encephalopathies. The agent is small and resistant to a number of detergents, lipid solvents, oxidants, enzymes, UV irradiation, and heating. The role of the isolate in the development of ALSP is verified by experimental reproduction of the disease in guinea pigs inoculated either with a brain suspension from ALSP patient or with the purified and concentrated agent. The true nature of ALSP in experimentally inoculated animals was verified by clinical, morphological, and virological studies.

Animals↗
PubMedDate not supplied

[Creutzfeldt-Jakob disease (prevalence and the problems of etiology and transmission)].

The literature on the prevalence, etiology, and transmission of subacute spongiform encephalopathy (Creutzfeldt--Jakob disease) is analysed. The author dwell at length on the incidence in various countries, mechanisms and ways of spread of this disease including those associated with medicinal treatment and everyday contacts. Clinico-morphological criteria of diagnosis are discussed.

Animals↗
PubMedDate not supplied

[Experimental amyotrophic leukospongiosis].

Experimental amyotrophic leukospongiosis (ALSP) has first been reproduced in 2 squirrel monkeys 16 and 23 months after inoculation of the animals with a brain suspension from the patient who had died of this disease. From the brain cell cultures of the monkeys a hemadsorbing agent was isolated which induced cell proliferation and was inhibited by the antisera from patients with ALSP.

Animals↗
PubMedDate not supplied

[Morphologic diagnosis of a seronegative case of HIV-infection].

Morphological diagnosis is described of a seronegative case of HIV-infection resulting in AIDS-dementia and development of a generalized herpes and aspergillosis. The presence of HIV-antigens in the central nervous system and the spleen histologic sections confirmed morphological diagnosis.

AIDS Dementia Complex↗