PubMed Health⌕ Search

Biomedical subjects

I I Stepanov

Publications and source records attributed to I I Stepanov.

At least 19 recordsLinked to original sources
PubMed2006

Regression analysis of relationship between liver weight and body weight after partial hepatectomy in rats.

A method for evaluation of the initial weight of the liver is developed for calculating the regeneration coefficient after partial hepatectomy on the basis of linear regression analysis. Experiments on rats showed that the model reflecting the relationship between liver weight and body weight for calculation of regeneration coefficient after partial resection of the liver expressed by the equation P0=0.033 x M can be used for screening of potential hepatoprotectors for quantitative evaluation of the regeneration processes.

Animals↗
PubMed1999

[The characteristics of the cholinoreceptors on the identified TAN neuron of the giant African snail Achatina fulica].

Acetylcholine, nicotine, a selective agonist of N-cholinoreceptors suberildicholine dibromide, as well as a selective agonist of M-cholinoreceptors 5-methylfurmethide inhibited spike discharges in a dose-dependent manner up to a complete ceasing of the firing in cholinoreceptors situated on the identified neurone TAN of African giant snail Achatina fulica. M-cholinoblocker metamizylum completely prevented the inhibitory effect of methylfurmethide. Central cholinoblocker aetherophen completely prevented the inhibitory effect of suberildicholine dibromide. Metamizylum or aetherophen used alone were only able to decrease the inhibitory effect of acetylcholine, whereas a mixture of these agents suppressed completely the acetylcholine-induced inhibition. The findings suggest that, on the TAN membrane, nicotinic and muscarinic cholinoreceptors co-exist and function in one and the same direction.

Acetylcholine↗
PubMed1980

[Incorporation of 3H-leucine into the brain proteins of rats following destruction of different nuclei of the serotoninergic system].

The incorporation rate of 3H-leucine into high- and low- molecular weight protein fractions of the motor cortex, hippocampal CA3 field and caudate nucleus was investigated after disruption of nucleus raphe dorsalis and nucleus raphe medialis to show an increase in the incorporation rate. The results obtained are discussed in the aspect of reciprocity of the serotonin- and noradrenergic systems on protein metabolism of the central nervous system.

Animals↗
PubMed1975

[Role of the intramural system of the cat colon in the organization of its rhythmic contractile activity].

Rhythmic contractility of the circular and longitudinal muscular layers of the cat colon in situ, after administration of blocking agents (atropin, phentolamine, and inderal), changes both in it spectral-frequency component and in the contraction strength of each layer, while the correlation between both layers contractions decreased from 69 to 28.9 percent. The colon rhythmic contractility is concluded to be a functionally organized process in conditions of intact innervation, the nervous system playing an active role in coordination of contractions of the circular and longitudinal muscular layers.

Animals↗
PubMedDate not supplied

Characteristics of cholinoreceptors on identified TAN neurons of the ground snail Achatina fulica.

The characteristics of cholinoreceptors located on neurons TAN1, TAN2, and TAN3 of the ground snail Achatina fulica were studied by incubation of the central ganglia in a bath with cholinotropic preparations during intracellular recording of background neuron spike activity. Acetylcholine, nicotine, the selective n-cholinoreceptor agonist suberyldicholine, and the selective n-cholinoreceptor agonist 5-methylfurmethide concentration-dependently inhibited background spike activity to the level of complete blockade at concentrations of 500 microM. The m-cholinoblocker metamizil (500 microM) completely prevented the inhibitory activity of concentrations of 5-methylfurmethide of up to 500 microM. The central n-cholinoblocker etherophen (500 microM) completely blocked the inhibitory activity of 500 microM suberyldicholine. However, metamizil and etherophen added separately only partially decreased the inhibitory effects of acetylcholine but could not completely block the effect of acetylcholine. At the same time, mixtures of metamizil and etherophen (500 microM each) completely blocked the inhibition of background spike activity induced by acetylcholine. These results show that both classes of cholinoreceptors act on TAN neurons in the same direction.

Action Potentials↗