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Biomedical subjects

I I Tovarova

Publications and source records attributed to I I Tovarova.

At least 19 recordsLinked to original sources
PubMed1981

[Not Available].

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History, Modern 1601-↗
PubMed1979

Myo-inositol-1-phosphate synthase from streptomyces griseus (studies on the biosynthesis of cyclitols, XXXVIII).

It could be shown that Streptomyces griseus, the microorganism producing the antibiotic streptomycin and also mutant strains of this species that cannot synthesize streptomycin, possess myo-inositol-1-phosphate synthase (EC 5.5.1.4), the enzyme cyclizing D-glucose 6-phosphate. The enzyme isolated from that organism is extremely instable, its molecular weight is approximately 260,000, and it requires a divalent metal ion for its activity. This is the first instance that an enzyme of this specificity has been found in a prokaryotic organism.

Carbohydrate Epimerases↗
PubMed1979

Influence of A-factor on the ultrastructure of the A-factor deficient mutant of Streptomyces griseus.

The fine structure of the A-factor deficient mutant strain of Streptomyces griseus grown in the absence or in the presence of this factor was studied by transmission electron microscopy. The submerged 96 h culture grown in the presence of the A-factor was characterized by the formation of a large amount of spores accompanied by mycelium disintegration. A number of essential ultrastructural changes were observed in the mycelium in the course of development and streptomycin biosynthesis after the A-factor addition. Thus, the cell wall was transformed in another manner at various developmental stages. For a long time the associated ribosomes were preserved. The number of intracytoplasmic membrane structures increased. New, unusual organelles appeared which consisted of parallel cylindrical structures. The possible nature of these organelles is discussed.

4-Butyrolactone↗
PubMed1975

[Characteristics of the interaction of the A-factor with mutant 1439 of Act. streptomycini in the biosynthesis of streptomycin].

Some peculiar properties of A-factor using by mutant 1439 of Act. streptomycini were studied. It was found that A-factor was most intensively used for biosynthesis of streptomycin when it was added during inoculation. When A-factor was added to a I- or 2-day culture it was required in 10 times higher amounts and its high non-specific adsorption by the mycelium was observed. Interaction of A-factor with the mycelium providing restoration of the biosynthetic process was very rapid on a short-term contat of the I-day culture with A-factor. Transformations occurring under the effect of A-factor and leading to formation of streptomycin took place mainly inside the cells. Changes in the life cycle induced by A-factor developed under different conditions as compared to those promoting streptomycin biosynthesis.

Bacteriological Techniques↗
PubMedDate not supplied

[Prospects for treating intraocular traumatic hemorrhage using a new fibrinolytic hemase].

Therapy of intraocular traumatic hemorrhage with the new drug hemaz is an important problem of ophthalmic traumatology. Seventy patients (76 eyes) with intraocular hemorrhages of traumatic origin were treated. Forty four patients (44 eyes) presented with hyphemas and 32 (32 eyes) with hemophthalmia. The results of hemaz therapy were compared with those of traditional treatment. The results confirm the high efficacy of hemaz which was well tolerated with sub-conjunctival and parabulbar injection. Indications for the use of this drug in clinical practice were formulated: it is recommended for the treatment of posttraumatic and postoperative hyphemas of any volume, including pupil hyphema, and for partial posttraumatic hemophthalmia.

Eye Hemorrhage↗
PubMedDate not supplied

[Effect of the A-factor on the adenylate level in Streptomyces griseus].

The adenylate content of various strains of Streptomyces griseus was measured. With respect to the ATP and ADP content the strains capable of spore formation, streptomycin synthesis and A-factor (2-isocapryloyl-3-hydroxymethyl-4-hydroxybutyrolactone) synthesis differed from the A-factor deficient mutants. The addition of the A-factor to the recipient strains decreased the intracellular content of ATP and the ATP/ADP ratio. The strain which is not an A-factor recipient did not modify the ATP content when the A-factor was added to the medium.

4-Butyrolactone↗